2008
DOI: 10.1111/j.1528-1167.2008.01535.x
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Seizures following picornavirus infection

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Cited by 111 publications
(211 citation statements)
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References 33 publications
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“…In Alzheimer's disease and ischemic injury, the PyNs in CA1 (9) sustain damage. Picornaviruses, including Theiler's murine encephalomyelitis virus (TMEV) (14,21) and encephalomyocarditis virus (22,23), target CA1 neurons in a way similar to that adopted by kainic acid in the same area (24). BDV also induces CA1 lesions but only in interferon-g-deficient knockout mice (18).…”
Section: Discussionmentioning
confidence: 99%
“…In Alzheimer's disease and ischemic injury, the PyNs in CA1 (9) sustain damage. Picornaviruses, including Theiler's murine encephalomyelitis virus (TMEV) (14,21) and encephalomyocarditis virus (22,23), target CA1 neurons in a way similar to that adopted by kainic acid in the same area (24). BDV also induces CA1 lesions but only in interferon-g-deficient knockout mice (18).…”
Section: Discussionmentioning
confidence: 99%
“…Approximately 50% of TMEV-infected C57BL/6 mice had seizures between days 3 to 10 postinfection (p.i.) (5). C57BL/6 mice infected with TMEV were able to clear the virusinfected cells by about day 14 p.i.…”
mentioning
confidence: 99%
“…C57BL/6 mice infected with TMEV were able to clear the virusinfected cells by about day 14 p.i. Furthermore, approximately 50% of the mice that had acute seizures went on to develop spontaneous seizures after an undefined latent period (approximately 2 months), suggesting that a certain percentage of mice, as is seen in humans, have an epilepsy-like phenotype following viral encephalitis (5,6). Therefore, the TMEV-induced seizure model is a viable model system to investigate the effect of an antiviral immune response on the CNS that could potentially lead to seizures/epilepsy.…”
mentioning
confidence: 99%
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“…We have been studying the role of the innate immune system in the development of acute behavioral seizures following CNS infection of C57BL/6 mice with a neurotropic virus (19,23). Infection with Theiler's murine encephalomyelitis virus (TMEV) results in acute seizures developing in more than 50% of C57BL/6 mice (both male and female) generally between days 3 and 10 postinfection (p.i.)…”
mentioning
confidence: 99%