Seizures Following Surgical Treatment of Intracranial Abscesses

Northcroft, George; Wyke, Barry

doi:10.3171/jns.1957.14.3.0249

Cited by 36 publications

(6 citation statements)

References 37 publications

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“…Few studies report long-term sequelae of brain abscess [4,6,27,[41][42][43]. Convulsive disorders subsequent to a brain abscess have been reported in 30-72% from different clinical and surgical series, studied for peri ods of time ranging from 3 months to 24 years, with the higher proportions reported by studies with longer follow-up.…”

Section: Discussionmentioning

confidence: 98%

Incidence and Prognosis of Brain Abscess in a Defined Population: Olmsted County, Minnesota, 1935–1981

et al. 1991

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The incidence of brain abscess was studied on all cases occurring in residents of Olmsted County, Minn., from 1935 through 1981. Thirty-eight cases (9 cases first diagnosed at autopsy) were identified and followed through the Rochester Olmsted County medical record-linkage system at the Mayo Clinic. The incidence rate was 1.3/100,000 person-years (PY), 1.9 in males and 0.6 in females. Incidence decreased from 2.7 in 1935–44 to 0.9 in 1965–81. Rates were higher in children 5–9 years old (2.4) and after age 60 (2.6 PY). An etiologic agent was identified in 29 cases (76%) with streptococci being the most frequently isolated. Case-fatality ratio was 38% (11/29), stable over time. Concurrent bacterial meningitis was the strongest predictor of death. Neurologic sequelae were observed in 8 (44%) of the 18 surviving patients including epilepsy (5 cases), deafness and motor impairment.

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Section: Discussionmentioning

confidence: 98%

Incidence and Prognosis of Brain Abscess in a Defined Population: Olmsted County, Minnesota, 1935–1981

et al. 1991

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“…He considered that early excision of the damaged area of brain might prevent this development, but that once a diffuse abnormality was established removal of the local lesion would not alter the situation. There may be a parallel between EEG abnormalities after head injury and the two different kinds of EEG abnormality which have been reported in the recovery period after brain abscess (Northcroft and Wyke, 1957). One consisted of bilateral synchronous paroxysms independent of the site of the abscess, which was regarded as the activation of an inherent convulsive disposition; the record of these patients, who usually had only generalized fits, often reverted to normal over a period of months.…”

Section: <Ooolmentioning

confidence: 95%

EEG Prediction of Post‐Traumatic Epilepsy

Jennett

Sande

1975

Epilepsia

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EEGs from 722 patients with injuries associated with a high risk of late traumatic epilepsy were analyzed. Although abnormal records were more common in patients who developed epilepsy, they reflected the more severe brain damage in these patients, which was already evident from clinical features. In individual patients the EEG does not improve the accuracy of the prediction calculated from clinical data. Patients with persisting or newly developing EEG abnormalities may never have a fit, while 20% of those with late epilepsy had at least one normal record in the first 3 months after injury. The conclusion that the EEG does not contribute usefully to the prediction of traumatic epilepsy appears to reflect a consensus among recent writers on the subject.

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“…The same incidence of seizures has been reported by Peserico, Nori & Ravenna (1965). Despite the fact that the importance of a correct prophylactic treatment in patients undergoing brain surgery has been stressed several times (Gaches & Suprino, 1970;Northcroft & Wike, 1957;Terzian, 1953Terzian, , 1954, quantitative data on this subject are very scanty indeed as recently underlined by Rapport & Penry (1973).…”

Section: Discussionmentioning

confidence: 66%

Carbamazepine and carbamazepine‐10, 11‐epoxide concentrations in human brain.

Pl¹,

Baruzzi²,

Gerna³

et al. 1977

Brit J Clinical Pharma

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I Carbamazepine (CBZ) brain and plasma concentrations were measured in twenty-one patients undergoing brain surgery for tumour removal. The drug was administered prophylactically at doses ranging from 6.9 to 14.8 mg/kg for 4-5 days before the intervention. 2 In seventeen cases where samples were collected 10-14 h after dosing, CBZ brain levels ranged from 2.2-14.5 jtg/g. A significant linear relationship (P< 0.01) was observed between brain and plasma concentrations with a brain/plasma ratio of 1.1 + 0.1. 3 Carbamazepine-10,11-epoxide (CBZ-Epox), present in all samples, could be quantified in three brain specimens. Its brain concentrations ranged from 1.5-2.7 gg/g with a brain/plasma ratio of4 Parieto-occipital areas tended to show higher CBZ concentrations while lower values were found in temporal regions. Very low CBZ levels were found in two gliomas while in meningiomas CBZ levels were similar to those observed in normal tissue. SThe data, showing a linear relationship between brain and plasma concentrations of both CBZ and its epoxide, give additional significance to the plasma level monitoring of antiepileptic drugs.

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Seizures Following Surgical Treatment of Intracranial Abscesses

Cited by 36 publications

References 37 publications

Incidence and Prognosis of Brain Abscess in a Defined Population: Olmsted County, Minnesota, 1935–1981

Incidence and Prognosis of Brain Abscess in a Defined Population: Olmsted County, Minnesota, 1935–1981

EEG Prediction of Post‐Traumatic Epilepsy

Carbamazepine and carbamazepine‐10, 11‐epoxide concentrations in human brain.

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