Seizures in Patients with Cerebral Palsy

Hosking, Gwilym; Miles, R N; Winstanley, Pat

doi:10.1111/j.1469-8749.1990.tb08129.x

Cited by 6 publications

(1 citation statement)

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“…In one study, multiple AEDs were used in 53% of patients with CP and epilepsy while only 30% were on multiple AEDs in those without CP [Zafeiriou et al, 1999]. Hoskings et al [ 1990] also reported that children with CP or MR and epilepsy are more likely to be on two or more AEDs, had more hospital admissions due to breakthrough seizures, and had more medication changes due to continued seizures or development of side effects compared to those without any developmental disability.…”

Section: Epilepsy In Specific Developmental Disabilitiesmentioning

confidence: 99%

Treatment of epilepsy in children with developmental disabilities

Depositario-Cabacar

Zelleke

2010

Dev Disabil Res Revs

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Children with developmental disabilities are at increased risk for epilepsy with a prevalence rate higher than the general population. Some of the more common developmental disorders in childhood and the features of epilepsy in these conditions are discussed. Specifically, autism, cerebral palsy, mental retardation, and attention deficit and hyperactivity disorder are reviewed. Ideal treatment for developmentally-disabled children with epilepsy entails maximal seizure control without any significant adverse effects from the anti-epileptic drugs and good quality of life. Antiepileptic drugs' cognitive and behavioral adverse effects tend to occur more frequently in these children. Careful selection of the appropriate medication and close monitoring for drug adverse effects is important. The specific adverse effects of the older and newer antiepileptic drugs are also reviewed.

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Section: Epilepsy In Specific Developmental Disabilitiesmentioning

confidence: 99%

Treatment of epilepsy in children with developmental disabilities

Depositario-Cabacar

Zelleke

2010

Dev Disabil Res Revs

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Epilepsy in children with cerebral palsy

et al. 2001

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This article deals with the clinical profile of children with cerebral palsy and epilepsy, and to study the clinical predictors of response to anti-epileptic drugs. It is a prospective hospital based follow-up study. All the children who presented with cerebral palsy and history of seizure (other than neonatal seizures) over a period of one year were included. Seizures were classified according to ILAE classification. An EEG was obtained in all cases. Neuroimaging was done in all patients. Eighty-five patients were studied and followed for minimum of 12 months. Perinatal factors accounted for 62 (72.3%) cases. The motor deficits seen were quadriparesis (n = 64), hemiplegia (n = 12) and diplegia (n = 9). Associated mental retardation was seen in 80.9% patients with quadriparesis. A predominance of generalised epilepsy was seen with generalised tonic clonic seizures (32.9%) followed by mycolonic seizures (30.6%) and localisation related epilepsy (24.7%). The patients with quadriparesis were more likely to have generalised epilepsy and 52.4% of them required two or more anti-epileptic drugs for control of seizures. Patients with hemiplegia had localisation related epilepsy in 83.3% of cases. On multivariate analysis presence of quadriparesis, microcephaly, mental retardation and myoclonic epilepsy were found to predict the poor response to AED. Epilepsy in patients with cerebral palsy is of severe nature and difficult to control. Presence of quadriparesis, mental retardation and myoclonic seizures was predictive of poor response to anti- epileptic drugs.

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