Seizures in Women With Preeclampsia: Mechanisms and Management

Cipolla, Marilyn J.; Kraig, Richard P.

doi:10.1017/s0965539511000040

Cited by 52 publications

(46 citation statements)

References 109 publications

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“…[12] Furthermore, the autoregulatory system of different vital organs like brain becomes inefficient at a blood pressure in excess of 150 mmHg resulting in extravasation of plasma into tissue and consequent oedema. [13] All these factors induce cellular oedema, ischaemia and immunological assault that are manifested in liver tissues as hepatocellular necrosis and elevation of liver enzymes. [14] In our study, we have shown this with elevated hepatic enzymes beyond their reference intervals in the case group (Table 1).…”

Section: Discussionmentioning

confidence: 99%

Metabolic Derangements as Indicators of Partial Hellp Syndrome

Roy¹,

Dasgupta²

2017

jemds

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Section: Discussionmentioning

confidence: 99%

Metabolic Derangements as Indicators of Partial Hellp Syndrome

Roy¹,

Dasgupta²

2017

jemds

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“…Preeclampsia occurs in 3-14% of pregnancies and is defined by maternal hypertension with abnormal proteinuria, generally also associated with oedema, coagulation abnormalities, and disseminated intravascular coagulation 11 . These conditions can also potentially lead to eclampsia, which is characterized by hyperreflexia and convulsions, and is associated with significant life-threatening complications like stroke, haemorrhage, oedema and brain herniation 12 . Several other signs and symptoms are also associated with preeclampsia, such as oedema, rapid weight gain, headaches, dizziness, tinnitus, altered consciousness, epigastric or right upper quadrant pain, liver tenderness, and oliguria or anuria.…”

Section: Introductionmentioning

confidence: 99%

The fluid balance observed postnatally on normal pregnancies, pregnancies with preeclampsia, and on pregnancies with oedema and proteinuria

Diamanti¹,

Κatsaounou²,

Vivilaki³

2017

Eur J Midwifery

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in arterial blood pressure and systemic vascular resistance. Mostly, all of these changes are generally reversed in weeks or months after delivery [1][2][3][4][5] . To be more specific, pregnancy is a volume-expanding state characterized by net sodium retention of 900 to 1000 mEq, as well water retention of 1.1 to 1.6 L, mediated by a balance between natriuretic and anti-natriuretic forces 1 . A rise in serum aldosterone is ABSTRACT INTRODUCTION It is observed that delivery does not completely eliminate the risk of developing symptoms of preeclampsia, as well as its impending complications. The postpartum period is often associated with a high risk of developing preeclampsia, eclampsia and HELLP syndrome. Yet, there is neither an established standard, nor specific guidelines for peripartum fluid management. Our purpose is to study during the first four days of the postpartum period the differences in fluid balance on: normal pregnancies, pregnancies with preeclampsia and pregnancies with oedema and proteinuria. METHODS The setting was the Gaia private maternity clinic in Athens, where 100 women in the postpartum period took part in the study and were requested to fill in a data collection-sheet, specially developed for the study. They were recruited between January 2014 and November 2014 and were divided into three groups. Group I consisted of all normal pregnancies, Group II those with oedema and proteinuria, and Group III those with preeclampsia. The demographic and clinical characteristics of the women and fetuses were initially recorded. Subsequently, daily records of fluid balance, as well as body weight, were kept for four days after labor. Descriptive statistics were used to analyze the demographic data of the sampled women. We compared the fluid balances among the three groups using t-test association and one-way Anova. RESULTS The mean age of the women was 32.48±4.38 years. Out of a total of 100 women, 59 of them had a normal pregnancy (Group I), 24 developed oedema and proteinuria (Group II) and 17 developed preeclampsia (Group III). All three groups had a positive fluid balance on the first day postpartum and only the first group had a negative cumulative fluid balance from the second day postpartum and onwards. The second group despite having started to discard a small volume of fluid, from the second day postpartum, the balance remained positive throughout the next two days. The third group however, had a negative fluid balance only during the fourth day after labor. CONCLUSIONS Our results indicate a difference in the kinetics of fluids in women with preeclampsia, compared to those that had a normal pregnancy and postpartum period. Consequently, there appears to be a need for more rational management and follow up on fluid balance throughout labor. INTRODUCTIONPregnancy involves remarkable changes in the anatomy and physiology that affect the renal and the cardiovascular system, in many aspects. These changes are in fact essential for the development and maintenance of a successful pregnancy, both ...

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“…Magnesium sulphate (MgSO 4 ) is an effective and safe drug which stabilizes the patient within few hours of eclampsia and controls subsequent seizures if given on time. 2 It is of utmost help if it can be given as soon as seizure develops. The number of seizures is one of the strongest determinants of poor feto-maternal outcomes.…”

Section: Introductionmentioning

confidence: 99%

Outcome of Eclamptic Mothers Attending Tertiary Care Centre from Home and those Referred from Primary Heath Care Site

Pandit¹,

Das²,

Banu³

et al. 2016

J Lumbini Med Coll

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Introduction: Magnesium sulphate (MgSO4) is an effective and safe drug which stabilizes the patient within few hours of eclampsia and terminates subsequent seizures if it is given on time. The aim of this study was to compare maternal and fetal outcome between a group of eclamptic mothers who came to the tertiary care hospital directly without receiving MgSO4 (Group 1) and those referred from primary care centers after receiving loading dose of MgSO4 (Group 2). Methods: This is a retrospective cohort study of eclamptic mothers who were admitted and managed from the period of 1st January 2012 to 31st March 2016 at Nepalgunj Medical College Teaching Hospital, Nepal. Sociodemographic characters and maternal and fetal outcome was compared between the two groups. Results: Among 92 cases, 57 (62%) were from Group 1 and 35 (38%) were from Group 2. Most of the mothers attended from Banke district (n=52, 56.5%) followed by Bardia district (n=17, 18.5%). Brahmin and Chhetri were 20 (35%) and 10 (29%); Muslim 16 (28%) and 4(11%); Janajati from Terai 16 (28%) and 8 (23%); Janajati from hilly region 4 (7%) and 5 (14%); and Chaudhari 1 (2%) and 8 (23%) in Group 1 and Group 2 respectively. More (n=26, 74%) mothers had baby with good Apgar score in Group 2 than in Group 1 (n=33, 58%). There were 14 (15.2%) still births; 9 (16%) in Group 1 and 5 (14%) in Group 2. Complication rate was observed more in Group 1 (n=16, 28%) than in Group 2 (n=7, 20%) and the most common complication in both groups was wound infection. The mean days of hospital stay was 5.96 (SD=3.32) and 5.91 (SD=3.38) in Group 1 and Group 2 respectively. Conclusion: The group receiving magnesium sulphate in primary care centre have good fetal outcome and less maternal complications compared to those who were admitted directly in tertiary care centre and receive the treatment there.

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Seizures in Women With Preeclampsia: Mechanisms and Management

Cited by 52 publications

References 109 publications

Metabolic Derangements as Indicators of Partial Hellp Syndrome

Metabolic Derangements as Indicators of Partial Hellp Syndrome

The fluid balance observed postnatally on normal pregnancies, pregnancies with preeclampsia, and on pregnancies with oedema and proteinuria

Outcome of Eclamptic Mothers Attending Tertiary Care Centre from Home and those Referred from Primary Heath Care Site

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