Selected aspects of synovial membrane physiology

McCarty, Daniel J.

doi:10.1002/art.1780170314

Cited by 18 publications

(5 citation statements)

References 23 publications

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“…In the hip joint capsule the flow was increasing from phase 1 to phase 4. The flow in the synovium presumably ceases when the intraarticular pressure passes the arterial pressure (McCarty 1974), indicating that the flow in phase 3 occurred exclusively in the fibrous part of the capsule. It may be suggested that the increased flow in phase 3 in the hip joint capsule is caused by an autoregulatory mechanism tending to restore the blood supply to the suffering femoral head and synovial membrane.…”

Section: Discussionmentioning

confidence: 99%

Blood Flow in the Juvenile Hip in Relation to Changes of the Intraarticular Pressure: An Experimental Investigation in Dogs

Lucht

Bünger

Krebs

et al. 1983

Acta Orthopaedica Scandinavica

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Section: Discussionmentioning

confidence: 99%

Blood Flow in the Juvenile Hip in Relation to Changes of the Intraarticular Pressure: An Experimental Investigation in Dogs

Lucht

Bünger

Krebs

et al. 1983

Acta Orthopaedica Scandinavica

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“…When the joint is affected by either disease or trauma this balance is upset. There can be a change in the permeability of the synovium to the passage of fluid into and out of the joint, and there may also be increased intra-articular metabolic demands (McCarty, 1974;Niinikoski & Einola, 1977). Both of these states can result in changes in composition and volume of the synovial fluid (Ropes & Bauer, 1953;Yehia & Duncan, 1975).…”

Section: S Nade and P J Newboldmentioning

confidence: 99%

Factors determining the level and changes in intra‐articular pressure in the knee joint of the dog.

Nade¹,

Newbold²

1983

The Journal of Physiology

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Intra‐articular pressure levels were determined for joint positions throughout the normal physiological range of movement of dogs' knee joints. Change in joint position resulted in change in intra‐articular pressure. It was demonstrated that intra‐articular pressure is highest with the joint in the fully flexed position. Minimum pressure was recorded at a position between 80 degrees and 120 degrees. Minimum pressures were usually subatmospheric. The rate of change of joint position affected intra‐articular pressure. The relationship of intra‐articular pressure and joint position before and after full flexion demonstrated a hysteresis effect; the pressures were lower than for the same joint position before flexion. Maintenance of the joint in the fully flexed position for increasing periods of time between repeated movement cycles resulted in a similar reduction, of constant magnitude, in pressure between joint positions before and after each period of flexion. However, there was also a progressive decrease in pressure for all joint angles over the total number of movement cycles. There is a contribution to intra‐articular pressure of joint capsular compliance and fluid movement into and out of the joint (both of which are time‐dependent). The recording of intra‐articular pressure in conscious, upright dogs revealed similar pressure levels to those measured in anaesthetized supine dogs. The major determinants of intra‐articular pressure in normal dog knee joints include joint size, synovial fluid volume, position of joint, peri‐articular tissue and joint anatomy, membrane permeability, capsular compliance, and movement of fluid into and out of the joint.

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“…The metabolism of the synovium is determined by many factors, including histological changes (hyperplasia of the synovial lining cell layer, infiltration of inflammatory cells), intra-articular pressure, and obliterative microangiopathy. [1][2][3][4][5][6][7] Synovial glucose metabolism via the anaerobic pathway producing lactate excess occurs in certain conditions, particularly infection. A rapid diagnostic test for septic arthritis is needed since delay in therapy can lead to irreversible joint damage.8 Estimation of synovial fluid (SF) lactic acid has been advocated as a rapid screening test.…”

mentioning

confidence: 99%