Selected aspects of the epidemiology of multiple sclerosis in Poland – a multicentre pilot study

Kułakowska, Alina; Bartosik-Psujek, Halina; Hożejowski, Roman; Mitosek-Szewczyk, Krystyna; Drozdowski, Wiesław; Stelmasiak, Zbigniew

doi:10.1016/s0028-3843(14)60134-1

Cited by 32 publications

(39 citation statements)

References 22 publications

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“…As seen in the present study and others [21][22][23][24][25], the QoL of MS patients depends on many factors and clinical parameters, such as disability level, disease duration, age, occupational status, and employed immunomodulatory therapy. These studies often differed methodologically because they were performed with various questionnaires and on different, often culturally divergent, populations.…”

Section: Discussionsupporting

confidence: 64%

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Multiple sclerosis: patient-reported quality of life in the Świętokrzyskie Region

Brola¹,

Sobolewski²,

Fudala³

et al. 2017

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Introduction: Comprehensive epidemiologic data for multiple sclerosis (MS) in Poland are limited. Aim of the research: To analyse patient-reported quality of life and selected clinical and socio-demographic factors of patients registered in the Świętokrzyskie Cohort of the Polish Registry of Multiple Sclerosis (RejSM). Material and methods: Participants were residents of Świętokrzyskie Province, and the data were collected between January 1 st 2014 and December 31 st 2015 by the RejSM web portal. After registration by doctors, the respondents assessed their quality of life individually using the Polish language versions of self-assessment questionnaires, the EuroQol (EQ-5D and EQ-VAS), and the Multiple Sclerosis Impact Scale (MSIS-29). Results: Of 1525 registered patients, 765 agreed to perform self-assessments of life quality and were included in the study. The mean degree of disability measured with the Expanded Disability Status Scale (EDSS) was 3.8 ±2.3. The mean EQ-5D index score was 0.78 ±0.28, and the mean EQ-VAS score was 65.6 ±23.8. Assessment score with MSIS-29 averaged 86.4 ±22.4 (64.2 ±19.6 for physical state and 24.7 ±7.8 for mental state). Only 34.7% of respondents were economically active. Lower quality of life was significantly associated with higher disability scores (p < 0.001), age over 40 years (p < 0.001), longer disease duration (p < 0.001), no access to therapy (p < 0.001), and unemployment (p = 0.002). No correlation was found between life quality and sex, course of disease, level of education, place of residence, or family status. Conclusions:The main factors decreasing life quality among patients in Świętokrzyskie Province are advanced disability, old age, long disease duration, and limited access to both employment and immunomodulatory treatment.

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Section: Discussionsupporting

confidence: 64%

“…In Poland, numerous attempts have been made to evaluate QoL among pa- Figure 1. Self-assessment of EQ-5D tients with MS, but these are usually limited to small patient groups, and are used for immediate purposes [21][22][23][24][25].…”

Section: Discussionmentioning

confidence: 99%

Multiple sclerosis: patient-reported quality of life in the Świętokrzyskie Region

Brola¹,

Sobolewski²,

Fudala³

et al. 2017

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show abstract

“…The disease usually manifests itself in young adults between 20 and 40-45 years old [12]. Some of the most commonly cited factors involved in the pathogenesis of MS are environmental factors (understood as climate, diet, certain pathogens or toxins), infections, genetic predisposition and autoimmunity.…”

Section: Plasma Mirna As Biomarkers Of Multiple Sclerosis Multiple Scmentioning

confidence: 99%

“…The geographical distribution of MS correlates with latitude and vitamin D3 deficiencies. The search for more precise biomarkers of MS is still underway [12].…”

Section: Plasma Mirna As Biomarkers Of Multiple Sclerosis Multiple Scmentioning

confidence: 99%

Plasmatic microRNA as Potential Biomarkers of Multiple Sclerosis: Literature Review

2016

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“…In Europe or the U.S. the incidence is 40-150 patients per 100,000 inhabitants, while in Poland this figure is 55-57 per 100,000 inhabitants, which means that the country is at high risk of MS occurrence. 6 The Caucasian race is the most vulnerable. The disease affects people of productive age leading to their disability.…”

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confidence: 99%

Rehabilitation in multiple sclerosis.

Kubsik-Gidlewska

Klimkiewicz

et al. 2017

Adv Clin Exp Med

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The aim of the study is to present a strategy of rehabilitation in multiple sclerosis on the basis of the latest developments in the field of physiotherapy. The publications on the problem discuss a wide range of methods of physiotherapy that can be used in order to reduce the degree of disability and alleviate the symptoms associated with the disease. The complexity of the disease, the difficulty in determining the appropriate treatment and a wide range of symptoms require a comprehensive approach to the patient, which would include both pharmacology and neurorehabilitation. Rehabilitation, which includes psychotherapy and symptomatic therapy, is regarded nowadays as the best form of treatment for multiple sclerosis. An indepth diagnostic assessment of functional status and prognosis should be carried out before the start of the rehabilitation process. The prognosis should take into account the mental state, the neurological status and the awareness of the patient. The kinesiotherapy program in multiple sclerosis is based on a gradation of physiotherapy which assumes a gradual transition from basic movements to more complex ones till global functions are obtained. The most appropriate form of treatment is functional rehabilitation combined with physical procedures. Recent reports indicate the need for aerobic training to be included in the rehabilitation program. The introduction of physical activities, regardless of the severity of the disease, will reduce the negative effects of akinesia, and thus increase the functional capabilities of all body systems.

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Selected aspects of the epidemiology of multiple sclerosis in Poland – a multicentre pilot study

Abstract: This project is the first countrywide large-scale MS survey, covering approximately 18% of patients, according to our estimates. The results identify the clinical condition of the patients, as well as diagnostic and treatment modalities.

Cited by 32 publications

References 22 publications

Multiple sclerosis: patient-reported quality of life in the Świętokrzyskie Region

Multiple sclerosis: patient-reported quality of life in the Świętokrzyskie Region

Plasmatic microRNA as Potential Biomarkers of Multiple Sclerosis: Literature Review

Rehabilitation in multiple sclerosis.

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