Selected dietary factors and breast cancer risk

Dydjow-Bendek, Dorota; Zagożdżon, Paweł

doi:10.32394/pe.73.29

Cited by 9 publications

(8 citation statements)

References 29 publications

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“…Numerous epidemiological studies indicate that BrCa is related to reproductive factors, such as early menarche below 12 years of age, late menopause above 55 years of age, nulliparity, miscarriages before the first full-term pregnancy, late age at first birth, infertility, and hormone usage. BrCa is also related to environmental factors that include high socio-cultural level, obesity, selected dietary habits, alcohol consumption, low physical activity, and exposure to ionizing radiation (used for therapeutic purposes) [ 9 , 10 , 11 , 12 , 13 , 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Oral Contraceptive Use and Breast Cancer Risk Assessment: A Systematic Review and Meta-Analysis of Case-Control Studies, 2009–2020

Barańska

Błaszczuk

Kanadys³

et al. 2021

Cancers

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To perform a meta-analysis of case-control studies that addressed the association between oral contraceptive pills (OC) use and breast cancer (BrCa), PubMED (MEDLINE), Embase, and the Cochrane Library were searched to identify case-control studies of OC and BrCa published between 2009 and 2020. We used the DerSimonian–Laird method to compute pooled odds ratios (ORs) and confidence intervals (CIs), and the Mantel–Haenszel test to assess the association between OC use and cancer. Forty-two studies were identified that met the inclusion criteria and we included a total of 110,580 women (30,778 into the BrCa group and 79,802 into the control group, of which 15,722 and 38,334 were using OC, respectively). The conducted meta-analysis showed that the use of OC was associated with a significantly increased risk of BrCa in general, OR = 1.15, 95% CI: 1.01 to 1.31, p = 0.0358. Regarding other risk factors for BrCa, we found that increased risk was associated significantly with early menarche, nulliparous, non-breastfeeding, older age at first parity, postmenopause, obesity, smoking, and family history of BrCa. Despite our conclusion that birth control pills increase the cancer risk being supported by extensive previous studies and meta-analyzes, further confirmation is required.

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Section: Introductionmentioning

confidence: 99%

Oral Contraceptive Use and Breast Cancer Risk Assessment: A Systematic Review and Meta-Analysis of Case-Control Studies, 2009–2020

Barańska

Błaszczuk

Kanadys³

et al. 2021

Cancers

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“…Breast cancer is linked to reproductive factors, such as early menarche before the age of 12 years, late menopause after the age of 55 years, nulliparity, late age at first birth, miscarriages before the first full-term pregnancy, infertility, and hormone use, according to several epidemiological studies. Breast cancer is also linked to environmental variables, such as high socioeconomic status, obesity, certain eating habits, alcohol use, poor physical activity, and ionizing radiation (therapeutic uses) [24][25][26][27][28][29][30]. We included six studies that examined the association between PCOS and breast cancer.…”

Section: Breast Cancermentioning

confidence: 99%

Risk of Gynecological Cancers in Women With Polycystic Ovary Syndrome and the Pathophysiology of Association

Shetty¹,

Rizvi²,

Sharaf³

et al. 2023

Cureus

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Polycystic ovary syndrome (PCOS) is an endocrine disorder increasingly affecting women in the reproductive age group. The women usually present with menstruation irregularities, hirsutism, weight gain, and acne. There has been ongoing research about the increased risk of gynecological cancers in women with polycystic ovary syndrome compared to those without it. This review aimed to understand the risk of gynecological cancers, endometrial, ovarian, and breast cancer in PCOS, and to study in detail the underlying mechanisms involved. We searched PubMed and Google Scholar databases for studies and selected 10 articles from a total of 19,388 relevant articles. We found an increased risk of endometrial cancer in women with PCOS whereas the risk of ovarian and breast cancer was not increased. A recent study has even reported a reduced risk of ovarian cancer in genetically predicted PCOS. In understanding various medical conditions possibly leading to cancer in these women we found that hyperandrogenism, hyperinsulinemia, unopposed estrogen action, chronic inflammation, and dyslipidemia were major contributors. There is a need for more large-scale cohort studies which will take into consideration other factors leading to cancers in women with PCOS, such as smoking, alcohol, and family history, to substantiate the significance of these associations further. The interventions used to treat PCOS might also affect the risk of cancer and require further probing. This review is an attempt to analyze the risk of cancers of the reproductive system in females with PCOS in coherence with understanding the mechanisms leading to the respective cancers.Categories: Endocrinology/Diabetes/Metabolism, Obstetrics/Gynecology, Oncology Keywords: pathophysiology of cancer in pcos, pcos and cancer risk, pcos and vulval cancer, pcos and cervical cancer, pcos and breast cancer, pcos and endometrial cancer, pcos and ovarian cancer, polycystic ovarian syndrome and gynecological cancers, gynecological cancers, pcos

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“…Breast cancer has become the most common cancer and the second-leading cause of cancer death in women worldwide [ 64 , 279 ]. Several risk factors are involved in the increase in breast cancer, including diet, lifestyle, age, gender, overweight, cumulative exposure to estrogen, alcohol, radiation, family history, smoking, and genetic factors [ 280 ]. The gut microbiota may be influencing clinical outcomes and side effects of early breast cancer management [ 281 ].…”

Section: Therapeutic Applications Of Berry-derived Polyphenolsmentioning

confidence: 99%

Chemical Compounds of Berry-Derived Polyphenols and Their Effects on Gut Microbiota, Inflammation, and Cancer

et al. 2022

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Berry-derived polyphenols are bioactive compounds synthesized and secreted by several berry fruits. These polyphenols feature a diversity of chemical compounds, including phenolic acids and flavonoids. Here, we report the beneficial health effects of berry-derived polyphenols and their therapeutical application on gut-microbiota-related diseases, including inflammation and cancer. Pharmacokinetic investigations have confirmed the absorption, availability, and metabolism of berry-derived polyphenols. In vitro and in vivo tests, as well as clinical trials, showed that berry-derived polyphenols can positively modulate the gut microbiota, inhibiting inflammation and cancer development. Indeed, these compounds inhibit the growth of pathogenic bacteria and also promote beneficial bacteria. Moreover, berry-derived polyphenols exhibit therapeutic effects against different gut-microbiota-related disorders such as inflammation, cancer, and metabolic disorders. Moreover, these polyphenols can manage the inflammation via various mechanisms, in particular the inhibition of the transcriptional factor Nf-κB. Berry-derived polyphenols have also shown remarkable effects on different types of cancer, including colorectal, breast, esophageal, and prostate cancer. Moreover, certain metabolic disorders such as diabetes and atherosclerosis were also managed by berry-derived polyphenols through different mechanisms. These data showed that polyphenols from berries are a promising source of bioactive compounds capable of modulating the intestinal microbiota, and therefore managing cancer and associated metabolic diseases. However, further investigations should be carried out to determine the mechanisms of action of berry-derived polyphenol bioactive compounds to validate their safety and examinate their clinical uses.

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Selected dietary factors and breast cancer risk

Cited by 9 publications

References 29 publications

Oral Contraceptive Use and Breast Cancer Risk Assessment: A Systematic Review and Meta-Analysis of Case-Control Studies, 2009–2020

Oral Contraceptive Use and Breast Cancer Risk Assessment: A Systematic Review and Meta-Analysis of Case-Control Studies, 2009–2020

Risk of Gynecological Cancers in Women With Polycystic Ovary Syndrome and the Pathophysiology of Association

Chemical Compounds of Berry-Derived Polyphenols and Their Effects on Gut Microbiota, Inflammation, and Cancer

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