Selected epidemiological features of human brucellosis in Yazd, Islamic Republic of Iran: 1993-1998

Salari, Mohammad; Khalili, Mohammad; Hassanpour, Gholamreza

doi:10.26719/2003.9.5-6.1054

Cited by 22 publications

(8 citation statements)

References 20 publications

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“…6,[17][18][19] Although children of all ages are susceptible to brucellosis, our sample properly reflected the age distribution of childhood brucellosis. 6,7 In our cohort, boys were more frequently diagnosed with brucellosis than girls. This is consistent with literature reports of boys comprising 55%-79% of childhood brucellosis cases.…”

Section: Discussionmentioning

confidence: 80%

“…1,2 Children account for approximately 10%-30% of all brucellosis cases. [3][4][5][6][7] Brucellosis can infect any organ or system. It is generally characterized by nonspecific complaints (fever, malaise, sweating) and abnormal physical findings (ie, hepatomegaly or splenomegaly).…”

mentioning

confidence: 99%

“…It is generally characterized by nonspecific complaints (fever, malaise, sweating) and abnormal physical findings (ie, hepatomegaly or splenomegaly). 2,[6][7][8][9][10] Prominent localized signs and symptoms are a consequence of the involvement of particular organs or systems such as the skeletal (osteoarticular; OA) system, nervous system or heart. [9][10][11] OA involvement is a common complication and the predominant manifestation of brucellosis in children, appearing in 10%-85% of cases involving children.…”

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confidence: 99%

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Osteoarticular Involvement in Childhood Brucellosis: Evaluation of Clinical, Laboratory and Radiologic Features of 185 Cases

Akkoç

Tekerek²

2023

Pediatric Infectious Disease Journal

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Backgrounds: Brucellosis is a systemic zoonotic disease. Osteoarticular (OA) system involvement is a common complication and the predominant manifestation of brucellosis in children. We aimed to evaluate the epidemiologic, demographic, clinical characteristics, and laboratory and radiologic findings of children with brucellosis and how these related to OA involvement. Methods: This retrospective cohort study consisted of all consecutive children and adolescents diagnosed as having brucellosis who were admitted to the pediatric infectious disease department of University of Health Sciences Van Research and Training Hospital between August 1, 2017, and December 31, 2018, in Turkey. Results: A total of 185 patients diagnosed as having brucellosis were evaluated, 50.8% had OA involvement (n = 94). Seventy-two patients (76.6%) exhibited peripheral arthritis involvement, among of them, hip arthritis (63.9%; n = 46) was the most common manifestation, followed by arthritis of knee (30.6%; n = 22), shoulder (4.2%; n = 3) and elbow (4.2%; n = 3). A total of 31 patients (33.0%) had sacroiliac joint involvement. Seven patients (7.4%) had spinal brucellosis. Erythrocyte sedimentation rate level above 20 mm/h at admission and age were independent predictor of OA involvement (respectively odds ratio [OR] = 2.82; 95% confidential interval [CI] = 1.41–5.64, ORperyear = 1.10; 95% CI: 1.01–1.19). Increasing age was associated types of OA involvement. Conclusion: A half of brucellosis cases had OA involvement. These results can help physicians to make early identification and diagnosis of childhood OA brucellosis who present with arthritis and arthralgia to enable the disease to be treated in time.

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Section: Discussionmentioning

confidence: 80%

mentioning

confidence: 99%

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confidence: 99%

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Osteoarticular Involvement in Childhood Brucellosis: Evaluation of Clinical, Laboratory and Radiologic Features of 185 Cases

Akkoç

Tekerek²

2023

Pediatric Infectious Disease Journal

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“…The present study was performed to evaluate the clinical and laboratory findings, management modalities, complications, and outcomes of brucellosis in children in Qazvin, Iran. This is of particular interest, because there are similar reports from other parts of the country with demographic and epidemiologic characteristics different from those of Qazvin; this study will allow a comparison of the findings from these different areas (7)(8)(9). While pasteurization of milk and milk products are developing in Iran, childhood brucellosis continues to be common in Iran, and knowledge about the disease and changes in its clinical course, complications, and outcome remain important.…”

Section: Objectivesmentioning

confidence: 84%

“…Childhood brucellosis remains a significant community health problem in Iran, despite a trend toward an overall decrease in the disease (7,9). The yearly incidence of brucellosis in our hospital has declined over time, but there remain reports of childhood brucellosis in provinces of Iran (7,9). Therefore, the evaluation of the clinical features and laboratory findings of brucellosis in children is of great importance.…”

Section: Discussionmentioning

confidence: 96%

Brucellosis in Children

2012

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Background: Brucellosis, a multisystem infection that may imitate other conditions, shows a low incidence during childhood and may be misdiagnosed. Brucellosis has become a major medical problem in a number of the provinces in Iran. Objectives: To study the epidemiology, clinical and laboratory features, and management of brucellosis. Patients and Methods:We reviewed the charts of all patients who were diagnosed with brucellosis and showed an agglutination titer of 1:160 or more for Brucella at the Department of Pediatric Infectious Diseases, Qods Hospital from March 1995 to March 2004. We collected information on the age, gender, history of unpasteurized milk or milk-product ingestion, presenting symptoms, and physical signs of the patients. We also collected results of routine laboratory tests, treatment, and treatment outcome. Results: Patients younger than 12 years of age constituted all cases of brucellosis admissions. One hundred seventy-five patients (107 male and 68 female, 1.6:1 ratio) were diagnosed with brucellosis and had a Brucella titer of 1:160 with an odds ratio (OR) of 1:160. Eighty-seven patients (50%) were 1-6 years of age, 86 patients (49%) were 7-12 years of age, and only 2 patients were < 1 year of age. One hundred (57%) patients were from rural areas, and 75 (43%) were from cities. The most frequent seasons of disease occurrence were summer (76, 43%) and spring (52, 30%); there were fewer cases in winter (24, 14%) and autumn (23, 13%). One hundred fourteen cases (65%) had a history of consuming unpasteurized milk or milk products. The most frequent symptoms were arthralgia (79%) and fever (78%). The most common physical findings were fever (51%) and arthritis (26%). Of the cases, 157 (89.5%) were acute, and 17 (9%) were chronic. A normal white blood cell count was found in 123 cases (71%); anemia, in 33 (19%); increased erythrocyte sedimentation rate (ESR), in 92 (53%); positive C-reactive protein (CRP), in 85 (48%), and positive radiologic changes, in 20 (11%). The most common antibiotics used were cotrimoxazole plus gentamycin in 83 cases (47.5%) and cotrimoxazole plus rifampin in 72 cases (41%). Conclusions: Brucellosis presents in various ways and should be differentiated from arthritis in countries where Brucella is endemic. Symptoms, signs, and first-line laboratory findings are not distinguishing; accordingly, agglutination tests and, if possible, blood culture should be performed in any child with prolonged fever. Treatment is effective, but disease prevention by education of high-risk families is indicated.

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Prevalence of positive autoimmune biomarkers in the brucellosis patients

et al. 2016

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Brucellosis is a chronic infectious disease with articular involvement. Discrimination between brucellosis and rheumatologic disorders is difficult in regions endemic for brucellosis. There are few studies about the rate of positive autoantibodies as rheumatologic biomarkers in brucellosis, and the prevalence is variable. In this study, the rheumatologic tests were studied in brucellosis patients. This cross sectional study was performed in two teaching hospitals in Tehran, Iran. Forty-nine patients with brucella infection and 42 healthy participants were enrolled in this study. Brucellosis was diagnosed on the basis of the clinical symptoms and positive serology for brucellosis. Rheumatic factor (RF) and antinuclear antibodies (ANA) were evaluated in all patients. Cyclic citrullinated peptides antibody (ACPA) and anti-double strand DNA (anti-dsDNA) were checked in all patients and control groups. Out of 49 patients, 15 (30.6 %) were RF positive and 4 (8.2 %) were ANA positive. Anti-dsDNA was concurrently positive with ANA in 1 patient (2 %) but ACPA titer was positive in 8 patients (16.3 %). None of the patients with positive autoantibody biomarkers fulfilled the criteria for rheumatologic disorders. The rate of positive RF in healthy people was significantly lower than patient group (2.4 vs. 30.6 %), but the positiveness rate of other biomarkers did not have significant difference in two groups. Sixty percent of the patients with positive RF and 75 % with positive ACPA had skeletal involvement (P < 0.05). Autoantibody biomarkers can be positive in brucellosis. Rheumatologists should be aware of brucellosis in patients with musculoskeletal involvement and positive autoantibody biomarkers in endemic regions.

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Selected epidemiological features of human brucellosis in Yazd, Islamic Republic of Iran: 1993-1998

Cited by 22 publications

References 20 publications

Osteoarticular Involvement in Childhood Brucellosis: Evaluation of Clinical, Laboratory and Radiologic Features of 185 Cases

Osteoarticular Involvement in Childhood Brucellosis: Evaluation of Clinical, Laboratory and Radiologic Features of 185 Cases

Brucellosis in Children

Prevalence of positive autoimmune biomarkers in the brucellosis patients

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