Selected excipients and surfactants in oral solid dosage form with extract of Phaseoli pericarpium (Phaseolus vulgaris L.)

Abstract

S u m m a r y Introduction:The common bean (Phaseolus vulgaris L.) is an annual plant grown in many countries all over the world including its different varieties in Poland. Herbal raw material are elongated pods -pericarp. Phaseoli pericarpium decreases the glucose blood level. Phaseoli pericarpium extracts manifest duretic properties, can be used in the treatment of edema, kidney diseases with decreased urinary excretion, nephrolithiasis. Objectives: To investigate the usefullness of selected excipients as carriers of dry extract from Phaseolus vulgaris pericarp. Methods: The method of direct tableting was used. In the further stage, the obtained tablets were subjected to appropriate tests. The first stage of the study evaluates Prosolv SMCC 50, PROSOLV EASYtab, EMDEX, Carmellose calcium and PRUV. These were used to manufacture 4 batches of tablets. In the second stage, an oral solid dosage was manufactured on the basis of the formulation composition of batch 1 tablets (Phaseoli pericarpium extract, Prosolv SMCC 50, PRUV). Then, different surfactants (cholesterol oxyethylate n TE = 30, cholesterol oxyethylate n TE = 40, Rofam n TE = 50), were successively added to this formulation, to obtain 3 batches of tablets. All 7 batches were manufactured in the Erweka tableting machine. Then, they were subjected to morphological tests and physicochemical evaluation. The release of active substances to 3 selected acceptor fluids (water, artificial gastric juice, artificial intestinal juice) was measured in accordance with the requirements of the general and specific monographs in European Pharmacopoeia 7. Results: The manufactured tablets had a smooth uniform surface with no stains, spalls or mechanical damage and yellow color originating from the extract. The obtained tablets, with surfactants in their com- INTRODUCTIONPhaseolus is a genus of the family Fabaceae including about 200 species of annual and perennial plants, vines and subshrubs with large leaves and white, yellow or red flowers [1]. The common bean (Phaseolus vulgaris L.) belongs to this family. It is an annual plant originating from South America. It is cultivated in many countries, including Poland, for food, dry seeds and immature pods. It exhibits a wide variety of seed coat patterns and colors [2,3].The pharmacopoeic material described in the Polish Pharmacopoeia VI [4] is the dried pericarp (bean pod, Phaseoli pericarpium) derived only from white-flowered cultivars of Phaseolus vulgaris. The pericarps are curled and slightly thin, up to 20 cm long and up to 2 cm wide. One end has a short beak-like point, while a 1 cm stalk is often attached to the other. The outside surface is pale yellow or dark brown yellow, the inside is covered with a whitish, shiny membrane. In the areas where seeds are present, the pericarp is concave inside and convex outside [4].The main pharmacologically active compounds of Phaseoli pericarpium are: choline, amino acids (arginine, asparagine, leucine, lysine), pipecolic acid, trigonelline, allantoin, phenolic acids, mineral ...

Selected Excipients in Oral Solid Dosage Form With Dry Extract of Pyrola Rotundifolia L.

“…In the selection of the best excipients in the development of solid dosage forms, different approaches are used [25,26]. One of the best is to use mathematical experiment planning.…”

SECONDARY METABOLITES OF Phaseoli pericarpium

“…Bean pericarp is a component of herbal mixtures and remedies used in diabetes phytotherapy, among others Diabetex-fix, Diabetosan-fix, Diabetofort, Diabetogran, and Diabetosol, as well as of the more following herbal mixtures: metabolic herbs -species metabolicae and diuretic herbs -species diureticae [Lamer-Zarawska et al 2014]. Research is also conducted on the preparation of a drug containing bean pericarp extract in the form of tablets [Marczyński et al 2015]. Bean pericarp is a medicinal material also applied in laryngology where its antiseptic, anti-inflammatory and astringent properties are used; isoprenoids, flavonoids, carbohydrates and related compounds as well as phenols, alkaloids and tannins belong to those active substances that are most frequently mentioned [Jędrzejko et al 2009].…”