Selected hematological abnormalities and their associated factors among asthmatic patients in Northwest Ethiopia: a cross-sectional study

Solomon, Yenealem; Woldu, Berhanu; Mesfin, Nebiyu; Enawgaw, Bamlaku

doi:10.1186/s12890-022-02020-z

Cited by 3 publications

(3 citation statements)

References 71 publications

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“…A study was conducted by the authors to know the anomalies in the hematological profile of patients suffering from asthma, in which they found out that the White blood cell count was higher when compared with healthy control. [9] In asthma, the severity and seriousness of impaired lung function are directly linked with leukocyte and eosinophil count in the blood. Thus, the blood count of leukocytes and eosinophils can be used as a marker for the severity of the impaired function of the lungs.…”

Section: Discussionmentioning

confidence: 99%

“…Eosinophils counter asthma and infection. [9] In allopathy, generally, asthma is treated by using bronchodilator drugs (for example β2-adrenoceptor agonists and leukotriene receptor antagonists) and corticosteroids that inhibit eosinophil function. Though these are very effective against asthma but have numerous adverse effects on the body.…”

Section: Introductionmentioning

confidence: 99%

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Comparison of the Anti-asthmatic Potential of Himalayan Plants Lonicera obovata Royle and Morina longifolia Wall: An in vivo Study

Boora¹,

Puri²,

Rani³

et al. 2023

Pharmacogn. Res.

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Background: Asthma is a very common and chronic disease in which there is an inflammation of the lungs. Inflammatory airways and narrowing, spasms, over-secretion of mucus, bronchoconstriction, and eosinophilic airway inflammation are generally seen in the asthmatic condition. Globally, its prevalence is rising constantly. The extracts of Lonicera obovata and Morina longifolia of the Caprifoliaceae family were traditionally used by the Himalayan local people to treat asthmatic and inflammatory conditions. Objectives: The goal of this experimental study was to identify the phytochemicals of the plants through GC-MS. To investigate and compare the anti-asthmatic potential of methanolic whole plant extracts of L. obovata and methanolic root extracts of M. longifolia through in-vivo experiments. Materials and Methods: The anti-asthmatic potential of extracts was determined by the method of leukocytosis and eosinophilia induced by milk in the Swiss albino mice model. Results: Various secondary active phytoconstituents were detected through the GC-MS screening method, some of which have anti-allergic (anti-asthmatic) and antihistaminic properties. The in vivo experiment result showed that in the case of increased leukocyte count, M. longifolia shows better results than L. obovata, and in the case of increased eosinophil count, L. obovata shows better results than M. longifolia to reduce the increased count. Conclusion:The anti-asthmatic potential of plant extracts could be due to the presence of the phytoconstituents like 1-Monolinoleoylglycerol trimethylsilyl ether in the L. obovata extracts and Octadec-9-enoic acid and Cis-vaccenic acid in both L. obovata and M. longifolia extracts. Hence, through the experiments, the unexplored anti-asthmatic properties were revealed and justifies the traditional usage of both plants to treat asthma.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Comparison of the Anti-asthmatic Potential of Himalayan Plants Lonicera obovata Royle and Morina longifolia Wall: An in vivo Study

Boora¹,

Puri²,

Rani³

et al. 2023

Pharmacogn. Res.

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show abstract

“…Growing evidence links chronic respiratory diseases with changes in markers of systemic inflammation, such as fibrinogen, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), interleukin 6 (IL-6), and procalcitonin (PCT), and blood count parameters, such as absolute neutrophil count (ANC), neutrophil percentage, absolute lymphocyte count (ALC), lymphocyte percentage, absolute eosinophil count (AEC), and eosinophil percentage [ 8 , 9 , 10 , 11 , 12 ]. There is surprisingly little knowledge about the practical relevance of these variables for separating between BA and COPD, although the development of such biomarkers is of great interest for daily clinical practice.…”

Section: Introductionmentioning

confidence: 99%

Serum YKL-40 Levels in Patients with Asthma or COPD: A Pilot Study

et al. 2023

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Background and Objectives: Bronchial asthma (BA) and chronic obstructive pulmonary disease (COPD) are not only common obstructive respiratory conditions but also major causes of morbidity and mortality worldwide. There is, however, a surprising lack of blood-based biomarkers for separating between these pulmonary disorders. The aim of this study was to assess the practical relevance of using serum YKL-40, single or combined, for this purpose. Materials and Methods: Subjects included Romanian patients with BA (n = 24) or COPD (n = 27). YKL-40, fibrinogen, pre-treatment C-reactive protein (CRP), post-treatment CRP, erythrocyte sedimentation rate, interleukin 6 (IL-6), procalcitonin (PCT), absolute neutrophil count, neutrophil percentage, absolute lymphocyte count, lymphocyte percentage, absolute eosinophil count, and eosinophil percentage were measured and compared between these patients. Results: This is the first study investigating the clinical significance of serum YKL-40 in delineating between COPD and BA in Caucasian populations. Only fibrinogen and YKL-40 levels were different between COPD and BA, with the measured values being significantly elevated. These patients exhibited distinct inflammatory profiles. Using the upper quartiles of these variables for the pooled study population (YKL-40: 5100 pg/mL; fibrinogen: 552 mg/dL) as cut-off values, subjects were classified into high or low groups. High YKL-40 adults revealed significantly increased PCT levels. High fibrinogen subjects, by contrast, showed significantly elevated IL-6 concentrations and pre-treatment CRP levels. Low YKL-40 and fibrinogen patients showed the absence of COPD. Conclusions: Combined use of serum YKL-40 and fibrinogen may be useful for identifying the absence of COPD.

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Lung function impairment may increase secondary thrombocytopenia susceptibility: a Mendelian randomization

Liu

Bin

Ran

et al. 2023

Preprint

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Purpose This study explored the relationship between lung function and secondary thrombocytopenia by analyzing Mendelian randomization (MR). Methods As instrumental genetic variables, appropriate single nucleotide polymorphisms (SNPs) were extracted from genome-wide association study (GWAS) data on lung function. We choose secondary thrombocytopenia as the outcome. Inverse variance weighting, weighted median methods, and MR- Egger's method were used to explore the association between lung function and the risk of secondary thrombocytopenia. The analysis results were shown as odds ratio (OR) and 95% confidence interval to evaluate the causal association between lung function parameters and secondary thrombocytopenia. Results The inverse variance weighted (IVW) analysis showed that forced expiratory volume in the first second (FEV1) significantly led to the occurrence of secondary thrombocytopenia [OR: 0.2126; 95% confidence interval (CI): 0.0508–0.8886, P = 0.0339], reduced peak expiratory flow (PEF) increased the occurrence of secondary thrombocytopenia [OR: 0.1018; 95% CI: 0.0143–0.7234, P = 0.0224]. The decline of FEV1 and PEF contributed to the risk of secondary thrombocytopenia. Furthermore, FVC (Forced Vital Capacity), FEV1/FVC, and lung volume were not associated with secondary thrombocytopenia. Conclusion FEV1 and PEF could be important precipitating factors of secondary thrombocytopenia, which provided new ideas for treating and preventing secondary thrombocytopenia.

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Selected hematological abnormalities and their associated factors among asthmatic patients in Northwest Ethiopia: a cross-sectional study

Cited by 3 publications

References 71 publications

Comparison of the Anti-asthmatic Potential of Himalayan Plants Lonicera obovata Royle and Morina longifolia Wall: An in vivo Study

Comparison of the Anti-asthmatic Potential of Himalayan Plants Lonicera obovata Royle and Morina longifolia Wall: An in vivo Study

Serum YKL-40 Levels in Patients with Asthma or COPD: A Pilot Study

Lung function impairment may increase secondary thrombocytopenia susceptibility: a Mendelian randomization

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