Selected loss of tolerance evidenced by Crohn's disease–associated immune responses to auto- and microbial antigens

Landers, Carol J.; Cohavy, Offer; Misra, Rajeev; Yang, Huiying; Lin, Yi‐Hao; Braun, Jonathan; Targan, Stephan R.

doi:10.1053/gast.2002.35379

Cited by 404 publications

(336 citation statements)

References 52 publications

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“…Specifically, Landers et al were able to demonstrate the stability of ASCA and other biomarkers during Infliximab treatment. 19 Teml et al found similar results in patients under 5-aminosalicylates and corticosteroids. 16 In line with this, Müller et al did not detect significant changes in ASCA levels in a cohort of CD patients observed over a period of 3 years.…”

Section: Discussionmentioning

confidence: 70%

The impact of intestinal resection on serum levels of anti‐Saccharomyces cerevisiae antibodies (ASCA) in patients with Crohn’s disease

Eser

Papay

Primas

et al. 2011

Aliment Pharmacol Ther

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Section: Discussionmentioning

confidence: 70%

The impact of intestinal resection on serum levels of anti‐Saccharomyces cerevisiae antibodies (ASCA) in patients with Crohn’s disease

Eser

Papay

Primas

et al. 2011

Aliment Pharmacol Ther

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“…Są to m.in. przeciwciała swoiste dla: 1) Saccharomyces cerevisiae (ASCA), 2) E. coli (anty-OmpC), 3) flageliny (anty-CBir1) -białka występującego na powierzchni bakterii, rozpoznawanego przez TLR5 [40]. U 20-30% chorych na SpA także stwierdza się przeciwciała swoiste dla S. cerevisiae, E. coli [35].…”

Section: Zaburzenia Homeostazy W Spondyloartropatiach Zapalnychunclassified

New aspects of spondyloarthritis pathogenesis. Part II – environmental factors, microbiome disturbances, extra-articular symptoms

Kontny¹

2014

Reumatologia

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Spondyloartropatie zapalne (SpA) to grupa chorób o podobnych cechach klinicznych i uwarunkowaniach genetycznych. Zakażenia bakteryjne układu pokarmowego i moczowo-płciowego są głównym czynnikiem środowiskowym związanym z rozwojem SpA. Nowe dane wskazują, że bakterie wewnątrzkomórkowe mogą rozprzestrzeniać zakażenie do innych miejsc anatomicznych. U chorych na SpA często występują objawy pozastawowe, zwłaszcza zapalenie jelit. Postęp w zrozumieniu roli mikrobioty jelitowej w homeostazie oraz nowe dane wskazujące na udział zaburzeń mikrobiomu w rozwoju różnych chorób pozwalają lepiej zrozumieć patogenezę SpA. Przypuszcza się, że SpA może się rozwijać na skutek przeniesienia do stawów odpowiedzi immunologicznej, która jest pierwotnie indukowana w jelicie. Przyczyną zapalenia jelit w SpA może być dysbioza, spowodowana przez czynniki genetyczne i środowiskowe.

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“…Screening lysates of cultures of colonic bacteria with a monoclonal P-ANCA antibody revealed that Escherichia coli outer membrane porin (OmpC) is an antigen in IBD [48]. Landers et al [49] reported antiOmpC antibodies in 55% of CD patients. The flagellin CBir1 has been identified as a dominant antigen capable of inducing colitis in C3H/ HeJBir mice and eliciting IgG antibody responses in a subpopulation (~50%) of patients with CD [16,50].…”

Section: Serological Markersmentioning

confidence: 99%

A Review on Clinicopathological Correlation between Classical Inflammatory Bowel Disease and Immunotherapy Related Inflammatory Bowel Disease

Allen¹

2014

Immunome Res

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Blockade of various immune targets such as cytotoxic T-lymphocyte antigen-4 and Programmed cell death leads to immune-mediated tumor regression and immune-related adverse events, predominantly gastrointestinal events including diarrhea and colitis. The current review is done to understand the underlying mechanism of action and to identify potential biomarkers that could help in the prediction and management of gastrointestinal immune-related adverse events. Histological assessment of bowel biopsies and assessment of serologic markers of inflammatory bowel disease and colitis secondary to immune mediated antibodies are reviewed. Ipilimumab causes dysregulation of gastrointestinal mucosal immunity, which can be evidenced by altered antibody levels to enteric flora and inflammatory cell infiltration into gastrointestinal mucosa associated with diarrhea and clinical evidence of colitis. The pattern of drug induced antibody titers to microbial flora and the histological features and location of the inflammation were distinct from classic inflammatory bowel disease. Although classic inflammatory bowel disease and immune mediated antibodies related gastrointestinal toxicity are both immune mediated, the pattern of biomarkers and histological features suggests that the later may be a distinct clinicopathologic entity.

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Selected loss of tolerance evidenced by Crohn's disease–associated immune responses to auto- and microbial antigens

Cited by 404 publications

References 52 publications

The impact of intestinal resection on serum levels of anti‐Saccharomyces cerevisiae antibodies (ASCA) in patients with Crohn’s disease

The impact of intestinal resection on serum levels of anti‐Saccharomyces cerevisiae antibodies (ASCA) in patients with Crohn’s disease

New aspects of spondyloarthritis pathogenesis. Part II – environmental factors, microbiome disturbances, extra-articular symptoms

A Review on Clinicopathological Correlation between Classical Inflammatory Bowel Disease and Immunotherapy Related Inflammatory Bowel Disease

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