One of the great challenges faced by the Nation's water-resources scientists is the need for reliable information that will guide the protection of our water resources. That challenge is being addressed by Federal, State, interstate, and local water-resource agencies, and by academic institutions. Many of these agencies are collecting water-quality data for a host of purposes, including compliance with permits and water-supply standards; development of remediation plans for specific contamination problems; operational decisions on industrial, wastewater, or watersupply facilities; and research on water quality. Prominent is the need for information of regional and national scope, and on the trends and causes of water-quality conditions. Without this information, policy decisions may be based on information from a few localized problems. Conversely, a lack of information may lead to a false sense that some problems do not exist. In the past two decades, billions of dollars have been spent on water-quality data-collection programs. However, only a small part of the data collected for these programs has been obtained specifically to assess the status, trends, and causes of water-quality conditions on regional and national scales. Also, in some instances, the utility of these data for present and future regional and national assessments is limited by such factors as the areal extent of the sampling network, frequency of sample collection, and the types of water-quality characteristics determined. Water-quality data collected for permits and for compliance and enforcement purposes constitute a sizable source of information that may be suitable for regional and national assessments. Such data must, however, be carefully screened before use. The needs, uses, and types of water-quality data vary widely, and data collected for one purpose are not necessarily suitable for other purposes. In fact, the use of unsuitable data in regional or national assessments can be much worse than a lack of information, because the use of such data can lead to incorrect conclusions having far-reaching consequences. Accordingly, the U.S. Geological Survey, with cooperation from other agencies and from universities, has undertaken a three-phase study in Colorado and Ohio to determine the characteristics of existing Federal and other public-agency waterquality data-collection programs and to evaluate the suitability of the data bases from these programs for use in water-quality assessments of regional and national scope. This report describes results of the second phase of the study. This study does not imply that past and present data-collection programs have failed or are inappropriate for their intended purposes. The data from those programs may fully meet individual agency needs and fulfill their mandated requirements, yet may have only limited relevance to water-quality questions of regional and national scope. This study has depended heavily on cooperation and information from many Federal, State, regional, and local agencies and academ...