The purpose of this study was to determine the remediation effect of various substances (manure, clay, charcoal, zeolite and calcium oxide) on limiting the influence of high cobalt doses (0, 20, 40, 80, 160 and 320 mg/kg of soil) on the content of macroelements in grain, straw and roots of oat. The doses of cobalt applied in this experiment as well as soil amendments such as manure, clay, charcoal, zeolite and calcium oxide had a significant effect on the content of the analysed macronutrients in grain, straw and roots of oat. In the series without any neutralising substances, the soil contamination with cobalt caused an increase in the content of nitrogen, phosphorus, sodium, calcium and, partly, potassium, in grain, straw and roots of oat. Among the neutralising substances tested, the most unambiguous effect was produced by manure, which raised the content of all macronutrients (except calcium and magnesium) in oat grain, straw and roots. The influence of the other substances on the content of macronutrients in oat plants was less equivocal. However, all of them, especially calcium oxide, tended to induce a decrease in the content of most macronutrients in grain, straw and roots of oat.