Selected recent developments in organo-cobalt chemistry

Abstract

and remained there for her PhD in the group of Dr Richards, working on the synthesis of planar chiral Fe and Co metallocenes. She moved to Germany to take up a postdoctoral fellowship at CaRLa and currently works at the University of Stuttgart. Her research interests include asymmetric catalysis using chiral organometallic complexes of first row elements Ben Ward graduated from Nottingham with an MSci and studied for his DPhil under Prof Mountford at the University of Oxford. He moved to the Universite´Louis Pasteur to work with Prof Gade and was awarded a Marie Curie fellowship to continue his research in Heidelberg. He moved to Cardiff as a lecturer in 2007; his research includes syntheses and applications of organometallic compounds in asymmetric catalysis

Synthesis of Chiral Cyclopentenones

“…Additionally, it is tolerant to a broad variety of functional groups, such as alcohols, ethers, thioethers, esters, nitriles, amines, amides, sulfonamides, etc. Therefore, the transformation has received great attention over the last few decades, and a wide number of records appeared in the literature, including a series of reviews. − The asymmetric versions are efficiently accomplished by applying a number of methods to introduce chirality. Depending on the stereochemistry of the reagents, the protocols can be divided into two general categories based on chiral auxiliaries attached either to the alkene or to the alkyne, or starting from achiral precursors.…”

X-ray Crystallographic and NMR Spectroscopic Study of (η2-Alkene)(μ-alkyne)pentacarbonyldicobalt Complexes: Arrested Pauson−Khand Reaction Intermediates

“…The Pauson−Khand reaction (PKR), the formal [2+2+1] cycloaddition of an alkyne, 1 , an alkene, 2 , and carbon monoxide, is a highly convergent method for the preparation of the cyclopentenone ring, 3 (see Scheme ) . The process was initially reported in 1973, and early examples focused on the use of dicobalt octacarbonyl as both the reaction mediator and the source of the carbonyl functional group.…”

Computational Study on the Co-Mediated Intramolecular Pauson–Khand Reaction of Fluorinated and Chiral N-Tethered 1,7-Enynes

“…The Pauson–Khand reaction (PKR) is one of the elementary methodologies for the construction of cyclopentenone derivatives, which can undergo subsequent chemical transformations to access more complex structures. 1 Since its discovery in the early 70s by Pauson and Khand, 2 this cobalt-mediated [2 + 2 + 1] cycloaddition has become an elegant and useful transformation for the synthesis of polycyclic molecules 3 and, in particular, for the synthesis of natural products containing the cyclopentenone motif. 4 The PKR is generally catalyzed by cobalt, but other transition metal catalysts, such as rhodium, 5 ruthenium, 6 nickel, 7 iridium, 8 titanium, 9 zirconium, 10 palladium, 11 and molybdenum, 12 have also shown catalytic activity on this cycloaddition.…”