Selected SNPs of FCN2 Associated with Chronic Tonsillitis in the Polish Adult Population

Abstract

Chronic tonsillitis is a problem related to bacterial and viral infections. Ficolins play a key role in the defence against various pathogens. In the present study, we investigated the associations between the selected single nucleotide polymorphisms (SNPs) of the FCN2 gene and chronic tonsillitis in the Polish population. The study included 101 patients with chronic tonsillitis and 101 healthy individuals. The selected SNPs of FCN2 (rs3124953, rs17514136 and rs3124954) were genotyped using TaqMan SNP Genotyping Assays (Applied Biosystem, Foster City, CA, USA). The analysis of rs17514136 and rs3124953 showed no significant differences in genotype frequencies between the chronic tonsillitis patients and controls (p > 0.01). The CT genotype of rs3124954 was significantly more frequent, while the CC genotype was less frequent in chronic tonsillitis patients (p = 0.003 and p = 0.001, respectively). The frequency of the A/G/T haplotype (rs17514136/rs3124953/rs3124954) was significantly more common in chronic tonsillitis patients (p = 0.0011). Moreover, the FCN2 CT genotype of rs3124954 was associated with a higher risk of chronic tonsillitis, while the CC genotype of rs3124954 decreased this risk. Our findings demonstrate that FCN2 rs3124954 may be associated with chronic tonsillitis in the Polish adult population.

Impact of Low-Temperature Plasma Radiofrequency Tonsillectomy on Pain, Inflammatory Markers, and Sleep Quality in Adults with Chronic Tonsillitis

“…Patients were divided into a control group and a treatment group based on varying treatment approaches. Inclusion criteria comprised: (1) age ≥18 years; (2) clinical diagnosis of CT with indications for tonsillectomy [12]; (3) presence of symptoms of chronic pharyngitis such as throat pain, difficulty swallowing, or persistent cough; (4) bilateral tonsils of grade III enlargement; (5) absence of other serious chronic diseases like heart disease or diabetes; (6) recurrent episodes of tonsillitis, occurring more than three times a year; (7) signed informed consent. Exclusion criteria included: (1) clear surgical contraindications; (2) acute tonsillitis instead of CT; (3) severe immune system disor-ders; (4) pregnant or lactating women; (5) incomplete case data; (6) patients who had undergone similar surgery previ-ously; (7) individuals with significant organ dysfunction in the heart, lungs, kidneys, etc.…”

“…This technique utilizes low-temperature plasma technology for precise removal of tonsillar tissue, reducing surgical duration, minimizing pain, shortening the recovery period, and promoting better postoperative outcomes. It offers a gentler alternative for the treatment of adult CT [6]. Lowtemperature plasma radiofrequency tonsillectomy achieves precise excision of tonsillar tissue while minimizing damage to surrounding normal tissues [7].…”