Selected topics of the wittig reaction in the synthesis of natural products

Kinetic Spectrophotometric Method for the 1,4-Diionic Organophosphorus Formation in the Presence of Meldrum′s Acid: Stopped-Flow Approach

“…The trivalent phosphorus compound is known to be a nucleophile, whereas it behaves as an electron donor toward a good electron acceptor either in the ground or excited state [1,2]. In recent years, there has been increasing interest in the synthesis of organophosphorus compounds, i.e., those bearing a carbon atom bound directly to a phosphorus atom [3,4,5,6,7,8,9,10,11,12,13,14,15]. This interest has resulted from the recognition of the value of such compounds in a variety of biological, industrial and chemical synthetic uses [3,4,5].…”

“…This interest has resulted from the recognition of the value of such compounds in a variety of biological, industrial and chemical synthetic uses [3,4,5]. A number of reactions have been observed that involve 1,4-diionic phosphorus compounds as elusive transient species [8,9,10]. In all of these reactions in which this diionic system was postulated, the betaines cannot be isolated, but appeared to occur as an intermediate on the pathway to an observed product.…”

A New Method of Formation of Tributyl-β- keto- and Tributyl-β-alkoxycarbonylalkylidenephosphorane from Tributyl[(trimethylsilyl) methylene]phosphorane and Their Application in the Wittig Reaction

“…The following years saw numerous modifications of the synthesis of β‑acylidenephosphoranes and also their new applications . For example, Wassermann and co‐workers developed direct acylation of stabilized phosphonium ylides by carboxylic acids in the presence of 1‐ethyl‐3‐(3‐dimethylaminopropyl)carbodiimide hydrochloride (EDCI)/N,N‐4‐dimethylaminopyridine (DMAP) .…”

Tributylphosphine as an Efficient Catalyst in C-Vinylation of Naphthol Derivatives

“…This interest has resulted from the recognition of the value of such compounds for a variety of industrial and chemical synthetic uses. Organophosphorus compounds also have been extensively used in organic synthesis as useful reagents as well as ligands of a number of trasition metal catalysts [11][12][13][14][15][16][17] . However, there are few reactions in which organophosphorus(III) species work as catalysts [17][18][19] .…”