Selected trace elements and minerals in cord blood: association with lipids and lipoproteins at birth

Bastida, Sara; Vaquero, M. Pilar; Veldhuizen, Marcel; Sánchez-Muniz, Francisco J.

doi:10.1080/080352500750027574

Cited by 13 publications

(13 citation statements)

References 28 publications

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“…This is consistent with a study conducted among Spanish newborns 24 and a cross-sectional study among hyperlipidemic Iraqi men, 20 although there was no correlation between copper and triglycerides among controls in the Iraqi study. Several other studies in children or adults have found positive relationships between copper and several forms of cholesterol, 19 HDL cholesterol, 15 or an unfavorable lipid profile (LDL/HDL >2.2).…”

Section: Discussionsupporting

confidence: 91%

Association of selenium and copper with lipids in umbilical cord blood

Wells

Navas‐Acien

Apelberg³

et al. 2014

J Dev Orig Health Dis

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Altered levels of selenium and copper have been linked with altered cardiovascular disease risk factors including changes in blood triglyceride and cholesterol levels. However, it is unclear whether this can be observed prenatally. This cross-sectional study includes 274 singleton births from 2004 to 2005 in Baltimore, Maryland. We measured umbilical cord serum selenium and copper using inductively coupled plasma mass spectrometry. We evaluated exposure levels vis-à-vis umbilical cord serum triglyceride and total cholesterol concentrations in multivariable regression models adjusted for gestational age, birth weight, maternal age, race, parity, smoking, prepregnancy body mass index, n-3 fatty acids and methyl mercury. The percent difference in triglycerides comparing those in the highest v. lowest quartile of selenium was 22.3% (95% confidence interval (CI): 7.1, 39.7). For copper this was 43.8% (95% CI: 25.9, 64.3). In multivariable models including both copper and selenium as covariates, copper, but not selenium, maintained a statistically significant association with increased triglycerides (percent difference: 40.7%, 95% CI: 22.1, 62.1). There was limited evidence of a relationship of increasing selenium with increasing total cholesterol. Our findings provide evidence that higher serum copper levels are associated with higher serum triglycerides in newborns, but should be confirmed in larger studies.

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Section: Discussionsupporting

confidence: 91%

Association of selenium and copper with lipids in umbilical cord blood

Wells

Navas‐Acien

Apelberg³

et al. 2014

J Dev Orig Health Dis

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“…440relationship between Cu and lipids found in previous studies. Thus, a positive association 441 between Cu and triglycerides has been observed in umbilical cord serum(Bastida et al, 2000; 442Wells et al, 2014) and between Cu and cholesterol in adults(Ghayour-Mobarhan et al, 2005).443 Nulliparous women those with an age between 25 and 29 years and those belonging to the lowest social class had the highest Cu concentrations. The relationship between maternal age 445 and some indicator of economic status (such as income or automobile possession) and cord 446 blood Cu concentrations was examined by Parajuli et al (2012); however they did not obtain 447 any statistically significant result (Parajuli et al, 2012).…”

mentioning

confidence: 98%

Maternal copper status and neuropsychological development in infants and preschool children

Amorós

Murcia

Gonzalez

et al. 2019

International Journal of Hygiene and Environmental Health

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Introduction: Copper (Cu) is an essential element involved in biological processes; however, excessive Cu could be harmful because of its reactive nature. Very few studies have evaluated 60 its potential neurotoxic effects. We aimed to evaluate the association between maternal Cu 61 levels and children's neuropsychological development. 62 Methods: Study subjects were mother-child pairs from the Spanish INMA (i.e. Childhood and 63 Environment) Project. Cu was measured by inductively coupled plasma mass spectrometry in 64 serum samples taken at the first trimester of pregnancy (2003-2005). Neuropsychological 65 development was assessed using the Bayley Scales of Infant Development (BSID) at 12 months 66 (n=651) and the McCarthy Scales of Children's Abilities (MSCA) at 5 years of age (n=490). 67 Covariates were obtained by questionnaires during pregnancy and childhood. Multivariate linear 68 and non-linear models were built in order to study the association between maternal Cu and 69 child neuropsychological development. 70 Results: The mean ± standard deviation of maternal Cu concentrations was 1606 ± 272 μg/L. In 71 the multivariate analysis, a negative linear association was found between maternal Cu 72 concentrations and both the BSID mental scale (beta=-0.051; 95% confidence intervals [CI]:-73 0.102,-0.001) and the MSCA verbal scale (beta=-0.044; 95%CI:-0.094, 0.006). Boys obtained 74 poorer scores than girls, with increasing Cu at 12 months (interaction p-value=0.040 for the 75 mental scale and 0.074 for the psychomotor scale). This effect modification disappeared at 5 76 years of age. The association between Cu and the MSCA scores (verbal, perceptive 77 performance, global memory and motor, general cognitive, and executive function scales) was 78 negative for those children with lowest maternal iron concentrations (<938µg/L). Conclusion: 79 The Cu concentrations observed in our study were within the reference range established for 80 healthy pregnant women in previous studies. The results of this study contribute to the body of 81 scientific knowledge with important information on the possible neurotoxic capability of Cu 82 during pregnancy.

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“…Klevay (1975) formulated the hypothesis that diets with high zinc/copper ratios are hypercholesterolemics. Our group (Bastida et al , 2000) found that in cord-blood calcium, magnesium, iron, zinc and copper levels were correlated with lipid and lipoproteins concentrations. Moreover, the inclusion of chromium decreases cholesterolemia and improves insulin sensitivity (Albarracin et al , 2007).…”

Section: Mineralsmentioning

confidence: 91%

“…This hypothesis was corroborated in newborn infants as high serum cholesterol levels were correlated to high serum zinc/copper ratios (Bastida et al , 2000). The levels of neonatal HDLc were also related to serum iron values (Bastida et al , 2000). Data from our group (Bocanegra et al , 2003; indicate that the zinc/copper dietary intake ratio, net iron absorption, and plasma cholesterol levels were lower in the Nori-fed rats than in the Konbu-fed ones, suggesting that this mineral ratio and iron bioavailability may infl uence cholesterolemia (Fig.…”

Section: Mineralsmentioning

confidence: 94%