Selectfluor™ F-TEDA-BF4 mediated thiocyanation or isothiocyanation of alcohols by in situ generation of [+SCN] under heterogeneous and neutral conditions

Copper-Catalyzed Intermolecular Trifluoromethylthiocyanation of Alkenes: Convenient Access to CF3-Containing Alkyl Thiocyanates

“…Therefore, much effort has been focused on the development of efficient methods for the introduction of the thiocyano group into small molecules. Traditional nucleophilic substitution of alkyl halides and alcohols is one of the most widely used methods for the synthesis of thiocyanates, and the isothiocyanate anion (NCS – ) can also undergo electrophilic reaction with allylic silanes and carbonyl compounds in the presence of oxidant. However, large excess amounts of strong oxidants and toxic metal thiocyanates are generally required.…”

Selectfluor as “Fluorine-Free” Functional Reagent Applied to Organic Synthesis under Transition Metal-Free Conditions

“…随后, Laali 等 [36] 在氮气氛 围中, 利用相同催化体系对底物进行了扩展(Scheme 9). 在此基础上, 武利强 [37] 和 Khazaei 等 [38] 也分别报道了酮 和醇的硫氰化反应(Eqs. 11, 12).…”

Photoredox-Catalyzed Intermolecular Radical Arylthiocyanation/Arylselenocyanation of Alkenes: Access to Aryl-Substituted Alkylthiocyanates/Alkylselenocyanates

“…Therefore, considerable effort has been made toward the development of efficient methods for the incorporation of a thiocyano group into small organic molecules. Traditional routes to this class of molecules include the nucleophilic substitution of thiocyanate to alkyl halides or alcohols and electrophilic thiocyanation of thiocyanate salts or isothiocyanate anion in the presence of oxidant. However, the major drawback associated with most of them is the use of a large excess of strong oxidants, low regio- and chemoselectivity, as well as limited substrate scope.…”