Selectfluor-mediated tandem cyclization of enaminones with diselenides toward the synthesis of 3-selenylated chromones

Abstract

A practical and efficient synthetic method has been developed for the construction of 3-selenylated chromones through the tandem cyclization of enaminones with diselenides in the presence of Selectfluor.

Electrocatalytic Cascade Selenylation/Cyclization/Deamination of 2-Hydroxyaryl Enaminones: Synthesis of 3-Selenylated Chromones under Mild Conditions

“…Among them, 2-hydroxyaryl enaminones appear as a powerful synthon to synthesize all kinds of functionalized chromones . Many chemists have developed several approaches for the synthesis of 3-selenylated chromones via the annulation of 2-hydroxyaryl enaminones with various selenyl source, such as diaryl diselenides, benzeneselenol, and phenyl hypochloroselenoite (Scheme a). However, these reported methods suffer from using a high loading amount of transition-metal, the employment of strong oxidants, low efficiency, and limited substrate scope.…”