Selectin‐P and interleukin‐8 plasma levels in coronary heart disease patients

Romuk, Ewa; Skrzep-Poloczek, Bronisława; Wojciechowska, Celina; Tomasik, Andrzej; Birkner, Ewa; Wodniecki, J; Gabrylewicz, Bogna; Ochała, Andrzej; Tendera, Michał

doi:10.1046/j.1365-2362.2002.01053.x

Cited by 70 publications

(39 citation statements)

References 28 publications

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“…The chemokine IL-8 may be involved in the pathogenesis of atherosclerosis and cardiovascular disease, since in vivo studies have found higher plasma levels of IL-8 in patients with unstable coronary heart disease (2,26). In vitro studies have demonstrated that several inflammatory cells involved in the pathogenesis of atherosclerosis possess IL-8 receptors (28), and IL-8 has been suggested to induce chemotaxis, which may be involved in the formation of atherosclerotic plaque (16,21).…”

Section: Discussionmentioning

confidence: 99%

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Higher production of IL-8 in visceral vs. subcutaneous adipose tissue. Implication of nonadipose cells in adipose tissue

Bruun

Lihn²,

Madan³

et al. 2004

American Journal of Physiology-Endocrinology and Metabolism

174

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IL-8 is released from human adipose tissue. Circulating IL-8 is increased in obese compared with lean subjects and is associated with measures of insulin resistance, development of atherosclerosis, and cardiovascular disease. We studied 1) the production and release of IL-8 in vitro from paired samples of subcutaneous (SAT) and visceral (VAT) adipose tissue and 2) the production of IL-8 from whole adipose tissue, isolated adipocytes, and nonfat cells of adipose tissue. IL-8 release from VAT was fourfold higher than from SAT ( P < 0.05), and IL-8 mRNA was twofold higher in VAT compared with SAT ( P < 0.01). Dexamethasone (50 nM) attenuated IL-8 production by 50% ( P < 0.05), and IL-1β (2 μg/l) increased IL-8 production up to 15-fold ( P < 0.001). IL-8 release from whole SAT explants correlated with body mass index (BMI; r = 0.78; P < 0.001), as did IL-8 release from nonfat cells ( r = 0.79; P < 0.001). However, no correlation was found between IL-8 release from the fraction of isolated adipocytes and BMI ( r = 0.01). In conclusion, we demonstrated an increased release of IL-8 from VAT compared with SAT. Furthermore, our data suggest that the observed elevation in circulating levels of IL-8 in obese subjects is due primarily to the release of IL-8 from nonfat cells from adipose tissue. The high levels of IL-8 release from human adipose tissue and accumulation of this tissue in obese subjects may account for some of the increase in circulating IL-8 observed in obesity.

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Section: Discussionmentioning

confidence: 99%

“…Besides its association with a number of different inflammatory processes, IL-8 has also been implicated in the pathogenesis of atherosclerosis (13,21) and coronary heart disease (26). Plasma levels of IL-8 have been found to be significantly increased in patients with both type 1 and type 2 diabetes compared with healthy subjects (9,29).…”

mentioning

confidence: 99%

Higher production of IL-8 in visceral vs. subcutaneous adipose tissue. Implication of nonadipose cells in adipose tissue

Bruun

Lihn²,

Madan³

et al. 2004

American Journal of Physiology-Endocrinology and Metabolism

174

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“…29,30 Enhanced IL-8 production was observed in human abdominal aortic aneurysms, 31 and IL-8 plasma levels were in increased coronary heart disease patients. 32 In addition, IL-8 was significantly increased in infarct-related coronary artery thrombi and atherosclerotic plaque specimens obtained with a transluminal extraction catheter from cases of acute myocardial infarction. 33 Because release of IL-8 and MCP-1 was also observed in oxLDL incubated macrophages, these cytokines may play an important role in the host response to inflammation 2 within the vessel wall and we therefore analyzed them as model cytokines.…”

Section: Dje N'guessan Et Al Statins Control Oxldl-related Histone Momentioning

confidence: 95%

Statins Control Oxidized LDL-Mediated Histone Modifications and Gene Expression in Cultured Human Endothelial Cells

N′Guessan

Riediger

Vardarova

et al. 2009

ATVB

112

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Objective-Activation of the endothelium by oxidized low-density lipoprotein (oxLDL) has been implicated in the development of atherosclerosis. Histone modifications impact on the transcriptional activity state of genes. We tested the hypothesis that oxLDL-induced inflammatory gene expression is regulated by histone modifications and experienced the effect of statins on these alterations. Methods and Results-OxLDL-related interleukin-8 (IL-8) and monocyte-chemoattractant protein-1 (MCP-1) secretion in endothelial cells was reduced by statins but enhanced by histone deacetylase inhibitors. OxLDL induced lectin-like oxidized LDL receptor-1 (LOX-1) and extracellular regulated kinases (ERK1/2)-dependent acetylation of histone H3 and H4 as well as phosphorylation of histone H3, both globally and on the promoters of il8 and mcp1. Pretreatment of oxLDL-exposed cells with statins reduced the above mentioned histone modification, as well as recruitment of CREB binding protein (CBP) 300, NF-B, and of RNA polymerase II but prevented loss of binding of histone deacetylase (HDAC)-1 and -2 at the il8 and mcp1 gene promoters. OxLDL reduced HDAC1 and 2 expression, and statins partly restored global HDAC-activity. Statin-related effects were reverted with mevalonate. In situ experiments indicated decreased expression of HDAC2 in endothelial cells in atherosclerotic plaques of human coronary arteries. Conclusions-Histone modifications seem to play an important role in atherosclerosis. (Arterioscler Thromb Vasc Biol.2009;29:380-386.)Key Words: endothelium Ⅲ cytokines Ⅲ statins Ⅲ histone Ⅲ HDAC A therosclerosis is a chronic inflammatory disease of the arterial wall. Increased oxLDL serum levels are considered as an important risk factor for atherosclerosis, 1,2 and oxLDL accumulation in the vessel wall has been suggested to trigger endothelial inflammation. 1 Expression of cyto-and chemokines and adhesion molecules by activated endothelium promotes monocyte/lymphocyte infiltration into the subendothelium thus stimulating inflammation of the vessel wall. 2 In particular, strong chemoattractants and proinflammatory cytokines like IL-8 and MCP-1 liberated by inflamed endothelium contribute to leukocyte attraction 2 in atherosclerosis. 3,4 LOX-1 is increasingly linked to atherosclerotic plaque formation. 5 LOX-1 activation by oxLDL stimulates endothelial proinflammatory gene expression and production of superoxide radicals. 5 Increasing evidence indicates that histone modifications are important for the transcriptional activity state of genes in many cellular processes. In chromatin, 146 base pairs of DNA are wrapped 1.65 turns around a histone octamer (H2A, H2B, H3, H4). 6 Transcription repression or gene activation is regulated by specific covalent modifications of accessible N-terminal histone tails 7,8 including acetylation (mostly lysine) and phosphorylation (serine/threonine). 9 For example, histone acetylases (HATs) increase histone acetylation thereby reducing DNA-histone binding and facilitating gene transcription whereas histo...

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“…Thus, MCP-1 appears to play a crucial role at multiple stages of atherosclerosis, and is a potent alternative biomarker and a possible therapeutic target (69). Similarly to the above, Romuk et al evaluated levels of CXC chemokine IL-8 and demonstrated significantly higher levels of IL-8 in unstable coronary heart disease patients in comparison to stable coronary heart disease patients and controls, concluding that a soluble form of IL-8 may be a useful clinical predictor of unstable coronary heart disease (70).…”

Section: Discussionmentioning

confidence: 99%

Chemokines in vascular pathology (Review)

Apostolakis

Papadakis²,

Krambovitis³

et al. 2006

Int J Mol Med

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Abstract. Clinical complications of atherosclerosis are major causes of morbidity and mortality in Western societies. Recent evidence suggests that formation of atherosclerotic lesions is an inflammatory process involving multiple molecular pathways. Chemokine-mediated mechanisms are potent regulators of such processes by orchestrating the interactions of inflammatory cellular components of the peripheral blood with cellular components of the arterial wall. The increasing evidence supporting the role of chemokine-pathways in atherosclerosis renders chemokine ligands and their receptors potential therapeutic targets. In the following review, we intend to highlight the special structural and functional features of each chemokine sub-family in respect to their role in atherosclerosis and discuss to what extent such knowledge could be applied in diagnostic, prognostic or therapeutic practices.

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Selectin‐P and interleukin‐8 plasma levels in coronary heart disease patients

Abstract: Our findings suggest that soluble form of selectin-P and interleukin-8 may be useful clinical predictors of unstable coronary heart disease. The assessment of the risk for the development of coronary heart disease requires further serial investigation.

Cited by 70 publications

References 28 publications

Higher production of IL-8 in visceral vs. subcutaneous adipose tissue. Implication of nonadipose cells in adipose tissue

Higher production of IL-8 in visceral vs. subcutaneous adipose tissue. Implication of nonadipose cells in adipose tissue

Statins Control Oxidized LDL-Mediated Histone Modifications and Gene Expression in Cultured Human Endothelial Cells

Chemokines in vascular pathology (Review)

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