Selectin‐P (PADGEM, GMP‐140)‐ mediated Adhesion of Human Platelets to Neutrophils in Vitro and Immune Complex‐induced Peritonitis in Rats Is Influenced by Interleukin‐8

Effects of inflammatory cytokines on the release and cleavage of the endothelial cell–derived ultralarge von Willebrand factor multimers under flow

“…39,40 Upon release, it activates endothelial cells, especially in microvascular endothelium 28,41 and mediates the formation of plateletleukocyte aggregates. 42 TNF-␣, predominantly derived from monocytes, 28 activates endothelial cells to release IL-8, IL-6, and other cytokines. 28,43,44 IL-6 has been previously demonstrated to exert procoagulant effects on platelets, 45,46 stimulate platelet production, 47,48 enhance platelet response to thrombin, 46 stimulate the hepatic release of C-reactive protein 49 and fibrinogen, 28 and promote the proliferation of vascular smooth muscle cells.…”