Selecting and Designing Polymers Suitable for Nanoparticle Manufacturing

Cammas‐Marion, Sandrine

doi:10.1007/978-3-319-41421-8_12

Cited by 1 publication

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“…Indeed, from their administration to their total elimination, nanocarriers and their constituents, have to: (i) be biodegradable or bioassimilable and biocompatible; and (ii) have a low opsonin recognition, a high loading capacity and a controlled drug release at the site of action. Among the nanovectors developed as drug carriers, polymeric nanoparticles (NPs) have attracted a great deal of attention because of the numerous possibilities of polymeric material modification allowing their physicochemical properties and those of corresponding nanocarriers to be adjusted to improve drug loading capacity and overall efficiency [5][6][7][8][9]. To design biocompatible and biodegradable nanocarriers, various natural and/or synthetic polymers have been used, among which the best known and most widely used are poly(lactic acid) and its derivatives [3].…”

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confidence: 99%

Nanoprecipitation of Biocompatible Poly(malic acid) Derivative, Its Ability to Encapsulate a Molecular Photothermal Agent and Photothermal Properties of the Resulting Nanoparticles

et al. 2021

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Biocompatible nanoparticles (NPs) of hydrophobic poly(benzyl malate) (PMLABe) were prepared by nanoprecipitation. The influence of nanoprecipitation parameters (initial PMLABe, addition rate, organic solvent/water ratio and stirring speed) were studied to optimize the resulting formulations in terms of hydrodynamic diameter (Dh) and dispersity (PDI). PMLABe NPs with a Dh of 160 nm and a PDI of 0.11 were isolated using the optimized nanoprecipitation conditions. A hydrophobic near infra-red (NIR) photothermally active nickel-bis(dithiolene) complex (Ni8C12) was then encapsulated into PMLABe NPs using the optimized nanoprecipitation conditions. The size and encapsulation efficiency of the NPs were measured, revealing that up to 50 weight percent (wt%) of Ni8C12 complex can efficiently be encapsulated with a slight increase in Dh of the corresponding Ni8C12-loaded NPs. Moreover, we have shown that NP encapsulating Ni8C12 were stable under storage conditions (4 °C) for at least 10 days. Finally, the photothermal properties of Ni8C12-loaded NPs were evaluated and a high photothermal efficiency (62.7 ± 6.0%) waswas measured with NPs incorporating 10 wt% of the Ni8C12 complex.

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