Selection and characterization of plant-derived alkaloids with strong antialgal inhibition: growth inhibition selectivity and inhibitory mechanism

Zhao, Guangpu; Yang, Hong; Li, Lihua; Zhang, Hongkai; Xu, Ran; Yuan, Hao

doi:10.1016/j.hal.2022.102272

Cited by 10 publications

(7 citation statements)

References 46 publications

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“…Similarly, our results demonstrated that chlorophyll (Chl a, Chl b) content declined after continuous cropping. One study showed the level of antioxidant enzymes SOD and the stress marker malonaldehyde (MDA) in the cells reflected the degree of oxidative damage [ 16 , 19 ]. In the present study, LZ significantly reduced the SOD activity and enhanced the MDA content, suggesting that the reduced SOD activity causing oxidative damage was indicated by increased malonaldehyde (MDA) contents.…”

Section: Discussionmentioning

confidence: 99%

TMT-Based Proteomic Analysis of Continuous Cropping Response in Codonopsis tangshen Oliv.

Jiang

Zhou

Wang

et al. 2023

Life

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The growth and development of Codonopsis tangshen, an important herb used in Chinese traditional medicine, have been seriously affected by continuous cropping obstacles. Therefore, understanding the molecular responses of C. tangshen to continuous cropping is imperative to improve its resistance to continuous cropping obstacles. Here, physiological and biochemical results showed that the levels of chlorophyll and malonaldehyde (MDA) were higher in the continuous cropping (LZ) group compared with those of the non-continuous cropping (FLZ) group, while superoxide dismutase (SOD) content was lower in the LZ group than in the FLZ group. Tandem mass tag (TMT)-based proteomic analysis was performed to investigate the response mechanism to continuous cropping obstacles in C. tangshen. A total of 70 differentially expressed proteins (DEPs) were significantly involved in relevant pathways, including photosynthesis, oxidative phosphorylation, ribosome activity, and secondary metabolites. The results suggest that these DEPs in C. tangshen might play a critical role in response to continuous cropping. These findings could provide scientific basis for improving C. tangshen’s resistance to continuous cropping obstacles.

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Section: Discussionmentioning

confidence: 99%

TMT-Based Proteomic Analysis of Continuous Cropping Response in Codonopsis tangshen Oliv.

Jiang

Zhou

Wang

et al. 2023

Life

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“…The community became more diverse with the addition of an algicide due to the increase in the number of species from the order Chlorophyta. Other studies have found that when plant-derived active compounds prevented cyanobacteria and microalgae blooms, phytoplankton diversity and species homogeneity increased [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

“…One of the most active areas of practical aquatic ecology and water management is the suppression of cyanobacteria and microalgae by active compounds (allelochemicals) of macrophyte origin or their synthetic equivalents [ 17 , 35 , 36 , 37 ]. Synthetic active compounds with good biological safety, similar to macrophyte metabolites, and pronounced specific action against cyanobacteria make them promising for use in HAB suppression.…”

Section: Discussionmentioning

confidence: 99%

“…Many macrophyte species actively produce these substances that inhibit the growth of cyanobacteria [ 11 , 12 , 13 , 14 , 15 , 16 ]. According to a review [ 17 ], 67 species of aquatic macrophytes from the genera Cabomba , Myriophyllum , Ceratophyllum , Elodea , Nuphar , Stratiotes , and the family Characeae are able to exhibit allelopathic activity against cyanobacteria. The use of aquatic macrophytes to prevent HABs is an effective method, but this approach has its own difficulties, including the need for further removal of macrophyte biomass and control of allochthonous nutrients [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

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Effects of Algicidal Macrophyte Metabolites on Cyanobacteria, Microcystins, Other Plankton, and Fish in Microcosms

Kurbatova,

Berezina,

Sharov

et al. 2023

Toxins

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To control harmful algae blooms (HABs), methods based on natural mechanisms are now required. We investigated the effects of an algicide derived from macrophyte metabolites, namely mixtures of gallic, tetradecanoic, heptanoic, and octanoic acids (1:1:1:1 mass ratio, a total concentration of 14 mg/L), on the biomass of cyanobacteria and other plankton and the production of microcystins under experimental conditions. Two types of microcosms have been created: simple (microalgae, cyanobacteria, and zooplankton) and complex (microalgae, cyanobacteria, zooplankton, and planktivorous fish). We observed the dynamics of the phytoplankton structure, the concentrations of microcystins and chlorophyll-a, hydrochemistry, and the status of zooplankton and fish in both types of microcosms with and without algicide for one month (from 19 July to 19 August 2021). The introduction of algicide caused changes in phytoplankton structure, a drop in cyanobacterial biomass, and a decrease in the total concentration of microcystins. Surprisingly, the contributions of the most toxic microcystins (LR form) were higher in both types of microcosms exposed to algicide than in microcosms without algicide. The inhibitory effect on the cyanobacterial biomass was most significant in complex ecosystems (containing fish), while it was only observed at the end of the exposure in simple ecosystems. Not only algicide but also phytoplankton consumed by fish and zooplankton, as well as nutrient excretory activity by both consumers, seem to have impact on cyanobacterial biomass. This study found that the using chemical substances similar to macrophyte metabolites can help regulate HABs and cyanotoxins. However, the results differ depending on ecosystem type.

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“…A quantity of studies had been widely used to find efficient molecular structures as potential algicides. − The 1,3,4-thiadiazole/oxadiazole/triazole skeleton has been favored by researchers because of its biological activities with a series of different abilities, such as antibacterial, antiviral, analgesic, antipsychotic, antiallergic, antitumor, and anti-inflammatory . In particular, the recent literature showed that the heterocyclic compounds containing phenyl substituents had significant anti-insect and antibacterial activities (Figure A). − Based on these good results, we have carried out an in-depth study on the algicidal effect of phenyl substituted heterocyclic modified molecules in order to find new and efficient algicidal agents and open up a new way for bioactive substrates.…”

Section: Introductionmentioning

confidence: 99%

Design, Synthesis, and Mode of Action of Thioacetamide Derivatives as the Algicide Candidate Based on Active Substructure Splicing Strategy

Huang,

Zuo,

Zhang

et al. 2024

J. Agric. Food Chem.

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Lakes and reservoirs worldwide are experiencing a growing problem with harmful cyanobacterial blooms (HCBs), which have significant implications for ecosystem health and water quality. Algaecide is an effective way to control HCBs effectively. In this study, we applied an active substructure splicing strategy for rapid discovery of algicides. Through this strategy, we first optimized the structure of the lead compound S5, designed and synthesized three series of thioacetamide derivatives (series A, B, C), and then evaluated their algicidal activities. Finally, compound A3 with excellent performance was found, which accelerated the process of discovering and developing new algicides. The biological activity assay data showed that A3 had a significant inhibitory effect on M. aeruginosa. FACHB905 (EC 50 = 0.46 μM) and Synechocystis sp. PCC6803 (EC 50 = 0.95 μM), which was better than the commercial algicide prometryn (M. aeruginosa. FACHB905, EC 50 = 6.52 μM; Synechocystis sp. PCC6803, EC 50 = 4.64 μM) as well as better than lead compound S5 (M. aeruginosa. FACHB905, EC 50 = 8.80 μM; Synechocystis sp. PCC6803, EC 50 = 7.70 μM). The relationship between the surface electrostatic potential, chemical reactivity, and global electrophilicity of the compounds and their activities was discussed by density functional theory (DFT). Physiological and biochemical studies have shown that A3 might affect the photosynthesis pathway and antioxidant system in cyanobacteria, resulting in the morphological changes of cyanobacterial cells. Our work demonstrated that A3 might be a promising candidate for the development of novel algicides and provided a new active skeleton for the development of subsequent chemical algicides.

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Selection and characterization of plant-derived alkaloids with strong antialgal inhibition: growth inhibition selectivity and inhibitory mechanism

Cited by 10 publications

References 46 publications

TMT-Based Proteomic Analysis of Continuous Cropping Response in Codonopsis tangshen Oliv.

TMT-Based Proteomic Analysis of Continuous Cropping Response in Codonopsis tangshen Oliv.

Effects of Algicidal Macrophyte Metabolites on Cyanobacteria, Microcystins, Other Plankton, and Fish in Microcosms

Design, Synthesis, and Mode of Action of Thioacetamide Derivatives as the Algicide Candidate Based on Active Substructure Splicing Strategy

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