Selection favors incompatible signaling in bacteria

Pérez‐Escudero, Alfonso; Gore, Jeff

doi:10.1073/pnas.1600174113

Cited by 4 publications

(5 citation statements)

References 20 publications

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“…We further showed the occurrence of mutual facultative cooperation between divergent QS alleles (also known as pherotypes) (Fig. 3b, d) [16, 44]. Each pherotype senses only its own signal.…”

Section: Resultsmentioning

confidence: 96%

Clonality and non-linearity drive facultative-cooperation allele diversity

2018

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Kin discrimination describes the differential interaction of organisms with kin versus non-kin. In microorganisms, many genetic loci act as effective kin-discrimination systems, such as kin-directed help and non-kin-directed harm. Another important example is facultative cooperation, where cooperators increase their investment in group-directed cooperation with the abundance of their kin in the group. Many of these kin-discrimination loci are highly diversified, yet it remains unclear what evolutionary mechanisms maintain this diversity, and how it is affected by population structure. Here, we demonstrate the unique dependence of kin-discriminative interactions on population structure, and how this could explain facultative-cooperation allele-diversity. We show mathematically that low relatedness between microbes in non-clonal social groups is needed to maintain the diversity of facultative-cooperation alleles, while high clonality is needed to stabilize this diversity against cheating. Interestingly, we demonstrate with simulations that such population structure occurs naturally in expanding microbial colonies. Finally, analysis of experimental data of quorum-sensing mediated facultative cooperation, in Bacillus subtilis , demonstrates the relevance of our results to realistic microbial interactions, due to their intrinsic non-linear frequency dependence. Our analysis therefore stresses the impact of clonality on the interplay between exploitation and kin discrimination and portrays a way for the evolution of facultative cooperation.

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Section: Resultsmentioning

confidence: 96%

Clonality and non-linearity drive facultative-cooperation allele diversity

2018

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“…Over the years several studies have considered the importance of quorum sensing as a control mechanism for public good production [7, 8, 13-15, 27-29]. Work done by You and colleagues has used a similar framework to establish the optimal regulation of quorum sensing.…”

Section: Discussionmentioning

confidence: 99%

Optimal strategy for public good production is set by balancing intertemporal trade-off between population growth rate and carrying capacity

Gangan

Vasconcelos

Mitra

et al. 2021

Preprint

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Public goods are biomolecules that contribute to the community welfare. Their production can benefit populations in many ways, such as by providing access to previously unutilized resources. However, public good production has often been energetically costly, resulting in a reduction in the cellular growth rate. To reduce this cost, populations have evolved strategies to regulate biosynthesis of public good. Among these cell densities dependent regulation of public goods, as accomplished by quorum sensing, is a widely studied mechanism. Given that the fitness costs and benefits of public good production must be balanced, adoption of quorum sensing as a regulatory pathway by bacterial cells may have parallels with several economic principles that are used to study optimal investment decisions. Here, we explore the regulation of a public good, whose benefit is an increase in the carrying capacity, through experimental measurements of growth for engineered strains of Escherichia coli and analysis of those results using a modified logistic growth model. By varying the cell density at which the production of the public good was activated, we showed sharply-peaked optimum population fitness. Analysis further revealed that cell density associated with maximum public good benefits was determined by the trade-off between the cost of public good production, in terms of reduced growth rate, and benefits received from public good, in the form of increased carrying capacity. Moreover, our model showed that cells with luxRI quorum sensing seem to upregulate public good expression when the benefits from the production was immediate. These results demonstrate a case where a biological system apparently has evolved to optimize the timing of public good production to account for short-term costs and delays in reaping a future benefit.

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Section: Figurementioning

confidence: 99%

“…This leads to emergence of cheaters in the population, which do not contribute toward production of the public resource, but gain from benefits from the resource produced by co-operators in the population. Because the cheaters have a higher fitness than the co-operators, but cannot survive in the absence of co-operators, a stable coexistence arises ( Perez-Escudero and Gore 2016 ; Pollak et al 2016 ). Presence of cheaters in an environment has also been shown to have a positive effect in preserving biodiversity in an unstructured space competition experiment between bacteria ( Leinweber et al 2017 ).…”

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confidence: 99%

Public good‐driven release of heterogeneous resources leads to genotypic diversification of an isogenic yeast population

et al. 2022

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Understanding the basis of biological diversity remains a central problem in evolutionary biology. Using microbial systems, adaptive diversification has been studied in (a) spatially heterogeneous environments, (b) temporally segregated resources, and (c) resource specialization in a homogeneous environment. However, it is not well understood how adaptive diversification can take place in a homogeneous environment containing a single resource. Starting from an isogenic population of yeast Saccharomyces cerevisiae, we report rapid adaptive diversification, when propagated in an environment containing melibiose as the carbon source. The diversification is driven due to a public good enzyme α‐galactosidase, which hydrolyzes melibiose into glucose and galactose. The diversification is driven by mutations at a single locus, in the GAL3 gene in the S. cerevisiae GAL/MEL regulon. We show that metabolic co‐operation involving public resources could be an important mode of generating biological diversity. Our study demonstrates sympatric diversification of yeast starting from an isogenic population and provides detailed mechanistic insights into the factors and conditions responsible for generating and maintaining the population diversity.

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Selection favors incompatible signaling in bacteria

Cited by 4 publications

References 20 publications

Clonality and non-linearity drive facultative-cooperation allele diversity

Clonality and non-linearity drive facultative-cooperation allele diversity

Optimal strategy for public good production is set by balancing intertemporal trade-off between population growth rate and carrying capacity

Public good‐driven release of heterogeneous resources leads to genotypic diversification of an isogenic yeast population

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