SELECTION FOR DELAYED SENESCENCE IN <i>DROSOPHILA MELANOGASTER</i>

Luckinbill, Leo S.; Arking, Robert; Clare, Michael J.; Cirocco, William C.; Buck, Steven

doi:10.1111/j.1558-5646.1984.tb00369.x

Cited by 403 publications

(142 citation statements)

References 14 publications

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“…In Drosophila melanogaster, some long-lived mutants have been shown to have greater metabolic capacity [96,97], resistance to heat, desiccation and ethanol, and have a higher activity of several antioxidant enzymes, including SOD [98]. Direct evidence for the significance of antioxidative defense for longevity in the fly has been obtained through generation of transgenic animals expressing copper/zinc SOD, catalase or both.…”

Section: Drosophila Melanogastermentioning

confidence: 97%

The role of insulin and IGF-1 signaling in longevity

Katic

Kahn

2005

CMLS, Cell. Mol. Life Sci.

151

115

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There are many theories of aging and parameters that influence lifespan, including genetic instability, telomerase activity and oxidative stress. The role of caloric restriction, metabolism and insulin and insulin-like growth factor-1 signaling in the process of aging is especially well conserved throughout evolution. These latter factors interact with each other, the former factors and histone deacetylases of the SIR family in a complex interaction to influence lifespan.

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Section: Drosophila Melanogastermentioning

confidence: 97%

The role of insulin and IGF-1 signaling in longevity

Katic

Kahn

2005

CMLS, Cell. Mol. Life Sci.

151

115

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“…Charlesworth 1980;Luckinbill et al 1984;Rose 1984), it is not based on the kind of post hoc curve-fitting that is used by demographers. Instead, the central theory for the evolution of aging is the a priori analysis of Hamilton (1966), particularly as elaborated and refined by Charlesworth (e.g.…”

Section: The Second Interpretation: Plateaus In the Forces Of Naturalmentioning

confidence: 99%

A revolution for aging research

et al. 2006

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In the year 1992, two publications on age-specific mortality rates revealed a cessation of demographic aging at later ages in very large cohorts of two dipteran species reared under a variety of conditions. Despite some initial concerns about possible artifacts, these findings have now been amply corroborated in the experimental literature. The eventual cessation of aging undermines the credibility of simple Gompertzian aging models based on a protracted acceleration in age-specific mortality during adulthood. The first attempt to explain the apparent cessation of aging was extreme lifelong heterogeneity among groups with respect to frailty. This lifelong heterogeneity theory assumes an underlying Gompertzian aging affecting every member of an adult cohort, with a merely apparent cessation of aging explained in terms of the increasing domination of a slowly aging group among the survivors to late ages. This theory has received several experimental refutations. The second attempt to explain the cessation of aging applied force of natural selection theory. This explanation of the cessation of aging has been corroborated in several Drosophila experiments. In particular, this theory requires that both age-specific survival and age-specific fecundity cease declining in late life, which has now been experimentally established. This theory also predicts that the timing of the cessation of aging should depend on the last age of reproduction in a population's evolutionary history, a prediction that has been corroborated. While lifelong heterogeneity should reduce average age-specific mortality in late life whenever it is pronounced, the cessation of aging in late life can be explained by plateaus in the forces of natural selection whether lifelong heterogeneity is present or not. The discovery that aging ceases is one of the most significant discoveries in recent aging research, with potentially revolutionary scientific implications.

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“…As males "wait" longer to begin sexual activity (10-11 days), this difference in longevity (12 days), as determined by the experiment in vials, meets the expectation of the antagonistic pleiotropy hypothesis of life-history theory (Williams 1957;Rose and Charlesworth 1981 ;Luckinbill et al 1984). The sexual difference in longevity determined by the experiment in chambers (8.6 days), is expected to be a better approximation of the natural situation, as effects on longevity of behaviors such as courtship, copulation, aggression, and flight, will be realized.…”

Section: Sex Differences and Osrsmentioning

confidence: 99%

Operational sex ratios and sperm limitation in populations of Drosophila pachea

Pitnick

1993

Behav Ecol Sociobiol

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Males of the cactophilic fruitfly, Drosophila pachea, produce relatively few but very large sperm, and partition their limited gamete numbers among successive mates. The present study found that males take 10 days longer than females, post-eclosion, to become sexually mature. The pattern of testes development suggests that the need to produce testes long enough to manufacture the giant sperm is the cause of the delayed male maturity. These findings generate the prediction that the operational sex ratio (OSR) of populations will be female-biased. The size, sex ratio, and OSR of natural populations were examined. In general, local populations tended to be small and sex ratios tended to be slightly male-biased. However, as predicted, the OSR of populations, at least in one season, tended to be female-biased, with an average of 2.3 receptive females for each sexually active male. Results of laboratory experiments to determine the relationship between female remating frequency and fitness, and between population OSR and productivity, suggest that natural populations with female-biased OSRs are sperm-limited. The origin and maintenance of sperm gigantism and the unusual sperm-partitioning behavior of males are discussed with respect to population structure.

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SELECTION FOR DELAYED SENESCENCE IN DROSOPHILA MELANOGASTER

Cited by 403 publications

References 14 publications

The role of insulin and IGF-1 signaling in longevity

The role of insulin and IGF-1 signaling in longevity

A revolution for aging research

Operational sex ratios and sperm limitation in populations of Drosophila pachea

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