Selection for life span in Drosophila melanogaster

Luckinbill, Leo S.; Clare, Michael J.

doi:10.1038/hdy.1985.66

Cited by 243 publications

(144 citation statements)

References 30 publications

Supporting

Mentioning

135

Contrasting

Unclassified

Order By: Relevance

“…Viability was not estimated in this study and percentage survivorship is measured from eclosion only. The long-lived parental line of this cross was from generation 16 of Luckinbill and Clare (1985 nor from the midparent value for parental lines. They are, however, significantly different from both long-and short-lived parental lines.…”

Section: Resultsmentioning

confidence: 99%

“…The long-lived parental strain used here was taken from the lines of the uncontrolled-density treatment of Luckinbill and Clare (1985) at generations 16 and 22. Populations of that study were collected locally in Michigan and following the method of Lints and Hoste (1974), were used to create a four-way hybrid stock.…”

Section: Methodsmentioning

confidence: 99%

“…If life span is under the nongenetic control of the maternal parent, as Lints and Hoste (1974) propose, then longevity in the F1 will correspond to that of the respective maternal parents and will not reflect its genetic composition by any conventional expression of dominance or additivity. And second, we further test the conclusion Of Luckinbill and Clare (1985) that controlling population density during development determines the life span expressed in adults. And finally, we attempt to distinguish between existing genetic theories of aging, particularly by testing Williams' (1957) prediction that antagonistic pleiotropy should occur between early-and late-life components of fitness.…”

Section: Ntrod U Ct! Onmentioning

confidence: 99%

“…In this study, we use the long-lived lines developed by Luckinbill and Clare (1985) in crosses with short-lived lines from the same origin to obtain an F1 generation. By comparing fecundity and longevity in parental and F1 populations, two predictions of theories of aging are tested, as well as a third concerning the influence of artifactual effects in these experiments.…”

Section: Ntrod U Ct! Onmentioning

confidence: 99%

See 3 more Smart Citations

The effects of gene-environment interaction on the expression of longevity

1985

Self Cite

View full text Add to dashboard Cite

Several previous attempts at selecting for increased life span with Drosophila have failed to obtain a response to selection, and postulate that life span is controlled by non-genetic maternal effects instead of genes. In other experiments, however, populations have responded. This study uses a set of true-breeding long-and short-lived stocks developed by in Vitro selection to examine the effect on life span of developmental environment and outcrossing.The expression of genes for life span is shown here to vary as a result of a gene-environment interaction and is strongly affected by the environment during development. The longevity of F1 crosses between long-and short-lived parental lines is additive when the density of larvae is high and unfixed, showing that life span is controlled by genes and not nongenetic maternal effects. But, when numbers of larvae are held low and constant, as in studies where selection fails, life span of crosses and parental lines is greatly restricted. The failure of some previous attempts at selection, therefore, appears to have resulted from the introduction, through experimental design, of strong artifactual environmental effects that Limit the phenotypic expression of genes for life span and the effectiveness of selection.Comparison of fecundity in parental and F1 lines shows that selection for increased life span antagonistically reduces early-life fecundity. Short-lived, parental lines, reproduced at an early age in life, lay 22-24 per cent more eggs in the same period than do long-lived lines selected for reproduction at a late age.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Ntrod U Ct! Onmentioning

confidence: 99%

Section: Ntrod U Ct! Onmentioning

confidence: 99%

See 2 more Smart Citations

The effects of gene-environment interaction on the expression of longevity

1985

Self Cite

View full text Add to dashboard Cite

show abstract

“…While virtually all species experience aging, organismal lifespan is an amazingly diverse trait in nature. For example, the documented maximal lifespans range from days in the medfly to over 500 years in clams, comprising all intermediaries including ~4 months in fruit flies, ~4 years in mice, ~120 years in humans, ~150 years in giant tortoises, and ~400 years in Greenland sharks (Butler, Wanamaker, Scourse, Richardson & Reynolds, 2013; Castanet, 1994; Karney et al., 2011; Luckinbill & Clare, 1985; Miller, Harper, Dysko, Durkee & Austad, 2002; Nielsen et al., 2016). The extraordinary diversity of lifespan and life history of various organisms raises many exciting possibilities for modeling and understanding the aging process.…”

Section: Research Organisms For Agingmentioning

confidence: 99%

The African turquoise killifish: A research organism to study vertebrate aging and diapause

Brunet²

2018

Aging Cell

135

118

View full text Add to dashboard Cite

SummaryThe African turquoise killifish has recently gained significant traction as a new research organism in the aging field. Our understanding of aging has strongly benefited from canonical research organisms—yeast, C. elegans, Drosophila, zebrafish, and mice. Many characteristics that are essential to understand aging—for example, the adaptive immune system or the hypothalamo‐pituitary axis—are only present in vertebrates (zebrafish and mice). However, zebrafish and mice live more than 3 years and their relatively long lifespans are not compatible with high‐throughput studies. Therefore, the turquoise killifish, a vertebrate with a naturally compressed lifespan of only 4–6 months, fills an essential gap to understand aging. With a recently developed genomic and genetic toolkit, the turquoise killifish not only provides practical advantages for lifespan and longitudinal experiments, but also allows more systematic characterizations of the interplay between genetics and environment during vertebrate aging. Interestingly, the turquoise killifish can also enter a long‐term dormant state during development called diapause. Killifish embryos in diapause already have some organs and tissues, and they can last in this state for years, exhibiting exceptional resistance to stress and to damages due to the passage of time. Understanding the diapause state could give new insights into strategies to prevent the damage caused by aging and to better preserve organs, tissues, and cells. Thus, the African turquoise killifish brings two interesting aspects to the aging field—a compressed lifespan and a long‐term resistant diapause state, both of which should spark new discoveries in the field.

show abstract

Evolution of human lifespan: Past, future, and present

Rose

Mueller

1998

Am. J. Hum. Biol.

View full text Add to dashboard Cite

Selection for life span in Drosophila melanogaster

Cited by 243 publications

References 30 publications

The effects of gene-environment interaction on the expression of longevity

The effects of gene-environment interaction on the expression of longevity

The African turquoise killifish: A research organism to study vertebrate aging and diapause

Evolution of human lifespan: Past, future, and present

Contact Info

Product

Resources

About