The paper proposes a method for forming a cyclogram of separating a large number (on the order of several tens or more) of spacecraft in one orbit, and determining the upper stage orientation program, which ensures a safe distancing of the spacecraft both among themselves and with the upper stage itself. We consider the application of this technique for the simultaneous and sequential separation of the spacecraft, as well as their combination. In this case, the relative speeds of object separation can be the same or different. We also give recommendations on how to carry out the maneuvers to de-orbit the upper stage after the completion of all operations in which the requirements for spacecraft surface non-contamination from the upper stage engine are met. The developed technique has been repeatedly tested during cluster launches of the Fregat upper stage.