Selection of a stationary phase for the chromatographic separation of organic acids obtained from bioglycerol oxidation

Coêlho, Lucas Cunha Duarte; Filho, Nelson M. Lima; Faria, Rui P. V.; Ribeiro, Ana M.; Rodrigues, Alírio E.

doi:10.1007/s10450-017-9882-5

Cited by 6 publications

(12 citation statements)

References 38 publications

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“…GLY oxidation results in several byproducts that must be separated from DHA for its commercial application. Dowex 50WX-2 resin in H + form was selected as the stationary phase for further experiments as it successfully separated GCA from TTA. , TTA and GCA adsorption equilibrium isotherms in the Dowex 50WX-2 in H + form were already determined and well-adjusted by a linear model . As DHA separation from the reaction mixture was not studied yet, GLY, DHA, OXA, and GCO adsorption equilibrium isotherms were determined.…”

Section: Resultsmentioning

confidence: 99%

“…Adsorption equilibrium isotherms of TTA in the Dowex 50WX-2 resin in H + form at 293 K: experimental data (dots) and linear model (full line). Data was already described in previous work, except at 12.8 g L –1 , as indicated in the figure.…”

Section: Resultsmentioning

confidence: 99%

“…Different research groups were successful in the implementation of chromatographic processes to perform the separation of compounds similar to glycerol oxidation products, mainly short-chain organic acids, using poly styrene-divinylbenzene (PS-DVB) ion-exchange resins functionalized with sulfonic groups as the stationary phase. − The separation of two glycerol oxidation products, GCA and TTA on a Dowex 50WX resin, was described in a previous work, using a commercial PS-DVB ion-exchange resin in H + form . A low cross-linking level of 2% was found to preferable over higher values, namely, 4% and 8% . The continuous chromatographic separation process was designed and optimized based on the true moving bed (TMB) technology, and the separation was accomplished experimentally using simulated moving bed (SMB) technology …”

Section: Introductionmentioning

confidence: 99%

“…A low cross-linking level of 2% was found to preferable over higher values, namely, 4% and 8% . The continuous chromatographic separation process was designed and optimized based on the true moving bed (TMB) technology, and the separation was accomplished experimentally using simulated moving bed (SMB) technology …”

Section: Introductionmentioning

confidence: 99%

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Dihydroxyacetone Production: From Glycerol Catalytic Oxidation with Commercial Catalysts to Chromatographic Separation

Walgode

Coêlho

Faria

et al. 2021

Ind. Eng. Chem. Res.

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A process for catalytic production of dihydroxyacetone through glycerol oxidation and dihydroxyacetone purification by chromatographic processes is herein presented. Glycerol oxidation over commercial Pt/AC and Pt−Bi/AC catalysts was performed on a batch reactor operating under base-free conditions, using water as a solvent and oxygen as the oxidant agent. The highest dihydroxyacetone yield obtained was 36%, using the Pt5%-Bi1.5%/AC catalyst, whereas the monometallic Pt/AC catalyst was selective to glyceric acid. It is herein reported for the first time dihydroxyacetone separation from unreacted glycerol and reaction byproducts (organic acids). Two commercial polystyrenedivinylbenzene ion-exchange resins were used as a stationary phase, one in the hydrogen form and the other in the calcium form, and water was used as the mobile phase. Adsorption equilibrium data for the species present in the reaction mixture were determined in both resins through single-component adsorption breakthrough experiments. A continuous chromatographic separation process was designed based on the simulated moving bed (SMB) technology and simulated using the gPROMS model builder software. A two SMB cascade was then considered, performing the pseudobinary mixture separation on the first SMB. The extract stream from the first SMB containing dihydroxyacetone and glycerol was fed to the second SMB, obtaining dihydroxyacetone with a purity of 97%. Considering the overall unit, a dihydroxyacetone productivity of 64 kg DHA (L Ads day) −1 was obtained with an eluent consumption of 1218 L Des kg DHA −1 .

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Dihydroxyacetone Production: From Glycerol Catalytic Oxidation with Commercial Catalysts to Chromatographic Separation

Walgode

Coêlho

Faria

et al. 2021

Ind. Eng. Chem. Res.

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“…A candidate reaction to convert the crude glycerol into high‐value chemical is the partial oxidation into glyceric acid (GA), which can be used as a pharmaceutical raw material (Coelho et al, 2017; Habe et al, 2010). This reaction proceeds under strong base conditions using an Au catalyst to give GA as the main product (Díaz et al, 2017; Mimura et al, 2014a, b).…”

Section: Introductionmentioning

confidence: 99%

Efficient Conversion of Glycerol into High Value‐Added Chemicals by Partial Oxidation

Chida

Hiromori

Shibasaki‐Kitakawa

et al. 2020

J Americ Oil Chem Soc

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Glycerol can be effectively converted to glyceric acid, a high value‐added pharmaceutical raw material, through its partial oxidation over an Au/Al2O3 catalyst under strongly basic conditions. The factors important for the highly selective production of glyceric acid were investigated experimentally. It was clarified that NaOH was involved in the glycerol activation step to a glycerol alkoxide intermediate (2, 3‐dihydroxypropoxide) in the liquid phase, then glyceric acid was formed by OOH species derived from O2 on an Au catalyst in the partial oxidation step. We have newly discovered the concerted effect of NaOH and O2 in different reaction steps.

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Pseudo-ternary chromatographic separation of dihydroxyacetone from the glycerol oxidation byproducts on a simulated moving bed cascade

Walgode,

Faria,

Rodrigues

2023

Chemical Engineering Journal

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Selection of a stationary phase for the chromatographic separation of organic acids obtained from bioglycerol oxidation

Cited by 6 publications

References 38 publications

Dihydroxyacetone Production: From Glycerol Catalytic Oxidation with Commercial Catalysts to Chromatographic Separation

Dihydroxyacetone Production: From Glycerol Catalytic Oxidation with Commercial Catalysts to Chromatographic Separation

Efficient Conversion of Glycerol into High Value‐Added Chemicals by Partial Oxidation

Pseudo-ternary chromatographic separation of dihydroxyacetone from the glycerol oxidation byproducts on a simulated moving bed cascade

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