Selection of Anopheles stephensi with DDT and dieldrin and cross-resistance spectrum to pyrethroids and fipronil

This study aimed to carry out a malaria situation analysis, species composition and susceptibility levels of the main malaria vector, Anopheles stephensi, to different insecticides in Bashagard. A longitudinal survey was conducted in 2 randomly selected villages in Bashagard. Malaria vectors were sampled by dipping method for the larvae and hand catch, night-biting catch, total catch, and shelter pit collection for the adults. Standard WHO susceptibility tests were used for a variety of insecticides on F1 progeny of An. stephensi reared from wild-caught females. In total, 693 adult anopheline mosquitoes and 839 third and fourth-instar larvae were collected and identified. They comprised 7 species; the most abundant adult and larvae anopheline mosquito was An. dthali (40.7% and 30.5% respectively). An. culicifacies (24.2%) and An. stephensi (16.7%) were the next most common species for adult mosquitoes. An. stephensi was fully susceptible to malathion and pyrethroid insecticides but resistant to DDT and tolerant to dieldrin.

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“…Recent studies have shown that An. stephensi from Bandar Abbas region is the most resistant to DDT [9]. In addition An.…”

Section: Introductionmentioning

confidence: 97%

Vector ecology and susceptibility in a malariaendemic focus in southern Islamic Republic of Iran

Soleimani-Ahmadi

Vatandoost²,

Shaeghi³

et al. 2012

Easter Mediterr Health J

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“…In insects, the GABAergic system is highly conserved and shows essential activity in neural physiology. Many insecticides, such as Dieldrin 22 , Fipronil 23 , and Bilobalide 24 , have been developed to interfere with insect GABAergic components. Nonetheless, the immune regulatory role of the insect GABAergic system has not been elucidated.…”

Section: Introductionmentioning

confidence: 99%

Blood meal acquisition enhances arbovirus replication in mosquitoes through activation of the GABAergic system

Zhu

Zhang

et al. 2017

Nat Commun

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Mosquitoes are hematophagous insects that carry-on and transmit many human viruses. However, little information is available regarding the common mechanisms underlying the infection of mosquitoes by these viruses. In this study, we reveal that the hematophagous nature of mosquitoes contributes to arboviral infection after a blood meal, which suppresses antiviral innate immunity by activating the GABAergic pathway. dsRNA-mediated interruption of the GABA signaling and blockage of the GABAA receptor by the specific inhibitors both significantly impaired arbovirus replication. Consistently, inoculation of GABA enhanced arboviral infection, indicating that GABA signaling facilitates the arboviral infection of mosquitoes. The ingestion of blood by mosquitoes resulted in robust GABA production from glutamic acid derived from blood protein digestion. The oral introduction of glutamic acid increased virus acquisition by mosquitoes via activation of the GABAergic system. Our study reveals that blood meals enhance arbovirus replication in mosquitoes through activation of the GABAergic system.

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“…Malaria control activities have been integrated in primary health centers of Iran since 1988 [9]. Resistance of Anopheles stephensi to DDT was first recognized in 1958 [10] and subsequently to dieldrin in 1960 [11] and Malathion in 1976 [12,13]. Many adulticides e.g.…”

Section: Introductionmentioning

confidence: 99%

The Field Practices of Lambdacyhalothrin and Deltamethrin Insecticides Against Adult Mosquitoes of Anopheles stephensi as the Main Vector of Malaria: Residual Effects

Khosravani

Rafatpanah

Amiri

et al. 2017

Zahedan J Res Med Sci

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Background: Various chemical control methods have adopted in anti-malaria interventions. Indoor residual spraying (IRS) has been proven as a candidate in elimination program. On the other hand, resistance to multiple insecticides was implicated as a concern issue in these polices. Pesticides should be evaluated to identify probable resistant and make decision to choose a technique against vectors. Methods:In this cross-sectional study, Bioassay test applied on lambdacyhalothrin WP 10% (0.05 mg a.i. /m 2 ) and deltamethrin WP 5% (0.05 mg a.i./m 2 ) on two surfaces (cement and plaster) against adult mosquitoes of Anopheles stephensi according to WHO criteria to measure the residual activity in Saravan county, southern Iran. Overall, 3960 mosquitoes was used in our research. The mortality rates of An.stephensi Liston (Diptera: Culicidae) measured between selected surfaces and insecticides in several times. Data analyzed by Mann-Whitney (nonparametric test) using SPSS v22 statistic software.Results: This paper illustrated that maximal course of residual efficacy was about 3 months. No statistically significant different was exhibited between type of surface within mortality rates of An. Stephensi (P = 0.724) but lambdacyhalothrin has more durability than deltamethrin Conclusions:We established that lambdacyhalothrin can be used into control and elimination setting of malaria with two rounds of spray at an interval of 3-4 months in south of Iran.

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Selection of Anopheles stephensi with DDT and dieldrin and cross-resistance spectrum to pyrethroids and fipronil

Cited by 39 publications

References 20 publications

Vector ecology and susceptibility in a malariaendemic focus in southern Islamic Republic of Iran

Vector ecology and susceptibility in a malariaendemic focus in southern Islamic Republic of Iran

Blood meal acquisition enhances arbovirus replication in mosquitoes through activation of the GABAergic system

The Field Practices of Lambdacyhalothrin and Deltamethrin Insecticides Against Adult Mosquitoes of Anopheles stephensi as the Main Vector of Malaria: Residual Effects

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