Selection of &lt;I&gt;D2S3&lt;/I&gt;, an &lt;I&gt;Aedes aegypti&lt;/I&gt; (Diptera: Culicidae) Strain with High Oral Susceptibility to Dengue 2 Virus and &lt;I&gt;D2MEB&lt;/I&gt;, a Strain with a Midgut Barrier to Dengue 2 Escape

Bennett, Kenneth A.; Beaty, Barry J.; Black, William C.

doi:10.1603/0022-2585(2005)042[0110:sodaaa]2.0.co;2

Cited by 30 publications

(22 citation statements)

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“…It was surprising that the Chetumal mosquitoes were as permissive to DENV-2 productive infection as the D2S3 strain, which was selected for DENV susceptibility [19]. The susceptible phenotype is likely conditioned by different genetic mechanisms, which remain to be determined.…”

Section: Discussionmentioning

confidence: 99%

“…Adult mosquitoes were maintained at 28°C, 70–80% relative humidity, with a 12–12 h light-dark photoperiod. Mosquitoes used as controls in tropism experiments were the Puerto Rico-Rex-D strain (a long colonized laboratory strain) [39] and the D2S3 strain (a laboratory selected, highly susceptible mosquito strain lacking a midgut escape barrier) [19]. …”

Section: Methodsmentioning

confidence: 99%

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Dengue virus type 2: replication and tropisms in orally infected Aedes aegypti mosquitoes

et al. 2007

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Background: To be transmitted by its mosquito vector, dengue virus (DENV) must infect midgut epithelial cells, replicate and disseminate into the hemocoel, and finally infect the salivary glands, which is essential for transmission. The extrinsic incubation period (EIP) is very relevant epidemiologically and is the time required from the ingestion of virus until it can be transmitted to the next vertebrate host. The EIP is conditioned by the kinetics and tropisms of virus replication in its vector. Here we document the virogenesis of DENV-2 in newly-colonized Aedes aegypti mosquitoes from Chetumal, Mexico in order to understand better the effect of vector-virus interactions on dengue transmission.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Dengue virus type 2: replication and tropisms in orally infected Aedes aegypti mosquitoes

et al. 2007

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“…These studies identified regions of the Ae. aegypti chromosome that contained one or more genes that influenced variation in the midgut escape barrier for DENV [79,80,81]. The identified QTL among the seven QTL detected in these studies varied in their influence depending on the geographic origin and maintenance in the laboratory of the Ae.…”

Section: Mosquito Genetic Factors Influence Mosquito Competence Fomentioning

confidence: 99%

Nature, Nurture and Evolution of Intra-Species Variation in Mosquito Arbovirus Transmission Competence

Tabachnick

2013

IJERPH

110

111

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Mosquitoes vary in their competence or ability to transmit arthropod-borne viruses (arboviruses). Many arboviruses cause disease in humans and animals. Identifying the environmental and genetic causes of variation in mosquito competence for arboviruses is one of the great challenges in public health. Progress identifying genetic (nature) and environmental (nurture) factors influencing mosquito competence for arboviruses is reviewed. There is great complexity in the various traits that comprise mosquito competence. The complex interactions between environmental and genetic factors controlling these traits and the factors shaping variation in Nature are largely unknown. The norms of reaction of specific genes influencing competence, their distributions in natural populations and the effects of genetic polymorphism on phenotypic variation need to be determined. Mechanisms influencing competence are not likely due to natural selection because of the direct effects of the arbovirus on mosquito fitness. More likely the traits for mosquito competence for arboviruses are the effects of adaptations for other functions of these competence mechanisms. Determining these other functions is essential to understand the evolution and distributions of competence for arboviruses. This information is needed to assess risk from mosquito-borne disease, predict new mosquito-arbovirus systems, and provide novel strategies to mitigate mosquito-borne arbovirus transmission.

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“…aegypti strains with different susceptibilities to DENV infection have been reported (namely DS3, DMEB and IBO-11), and these have been used to study whether midgut cell receptors for DENV may be markers for VC (Bennett and Beaty, 2005). Ae.…”

Section: Infection With Dengue Virusmentioning

confidence: 99%

Abbreviations and acronyms

2018

Harmonisation of Regulatory Oversight in Biotechnology

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This work is published under the responsibility of the Secretary-General of the OECD. The opinions expressed and arguments employed herein do not necessarily reflect the official views of OECD member countries.This document, as well as any data and any map included herein, are without prejudice to the status of or sovereignty over any territory, to the delimitation of international frontiers and boundaries and to the name of any territory, city or area.Please cite this publication as: OECD (2018) The statistical data for Israel are supplied by and under the responsibility of the relevant Israeli authorities. The use of such data by the OECD is without prejudice to the status of the Golan Heights, East Jerusalem and Israeli settlements in the West Bank under the terms of international law.Photo credits: Cover © Maks Ershov.Corrigenda to OECD publications may be found on line at: www.oecd.org/about/publishing/corrigenda.htm. © OECD 2018You can copy, download or print OECD content for your own use, and you can include excerpts from OECD publications, databases and multimedia products in your own documents, presentations, blogs, websites and teaching materials, provided that suitable acknowledgment of the source and copyright owner(s) is given. All requests for public or commercial use and translation rights should be submitted to rights@oecd.org. Requests for permission to photocopy portions of this material for public or commercial use shall be addressed directly to the Copyright Clearance Center (CCC) at info@copyright.com or the Centre francais d'exploitation du droit de copie (CFC) at contact@cfcopies.com. FOREWORD │ 3SAFETY ASSESSMENTOF TRANSGENIC ORGANISMSIN THE ENVIRONMENT, VOLUME 8 © OECD 2018 ForewordModern biotechnologies are applied to plants species (crops, flowers, trees), animals and micro-organisms. The safety of the resulting transgenic organisms when released in the environment for their use in agriculture, forestry, the food and feed industry or for other applications represents a challenging issue. Genetically engineered products are rigorously assessed by their developers during their elaboration, and by governments when ready for release, to ensure high safety standards. This remains essential with new biotechnology developments using insects to fight against disease outbreaks: engineered mosquitoes need to be evaluated through a scientifically sound approach to risk/safety assessment that will inform biosafety regulators and support the decision concerning the release of these novel organisms in the environment.The OECD offers a long-standing recognised expertise in biosafety and contributes to facilitating an harmonised approach. The OECD's Working Group on Harmonisation of Regulatory Oversight in Biotechnology (WG-HROB) was established in 1995. The WG-HROB gathers national authorities responsible for the environmental risk/safety assessment of products of modern biotechnology in OECD countries and other economies. International organisations and experts involved in biosafety activities are a...

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Selection of <I>D2S3</I>, an <I>Aedes aegypti</I> (Diptera: Culicidae) Strain with High Oral Susceptibility to Dengue 2 Virus and <I>D2MEB</I>, a Strain with a Midgut Barrier to Dengue 2 Escape

Cited by 30 publications

References 59 publications

Dengue virus type 2: replication and tropisms in orally infected Aedes aegypti mosquitoes

Dengue virus type 2: replication and tropisms in orally infected Aedes aegypti mosquitoes

Nature, Nurture and Evolution of Intra-Species Variation in Mosquito Arbovirus Transmission Competence

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