Selection of Pneumatic Reduction in Invagination Treatment and the Factors Affecting the Success of This Method

Abstract

ObjectiveTo retrospectively evaluate the success rates of fluoroscopy-guided pneumatic reduction in children with intussusception and to determine the risk factors and patient characteristics affecting the success of this method.Materials and methodsRetrospective evaluation was made of a total of 183 children diagnosed with ultrasonography (USG) and treated in the pediatric surgery clinic between August 2010 and December 2017. Data related to gender, age (month), date of presentation, invaginated segment localizations and treatment modalities were retrieved from the patient files.In children who underwent pneumatic reduction, surgical success was determined as the visualization of air flow through the small intestine on fluoroscopy and patients who received reduction were followed up in our clinic. No progress of the air given or failure to see the air flow to the small intestine despite some progression of the air was evaluated as failure and surgical procedure was started in 39 patients. All patients were followed up at the hospital for at least 24 to 48 hours after the procedures.Patients with perforation, peritonitis, vital instability, or general condition disorder during presentation at our clinic (n = 29) were directly admitted for surgery.ResultsThe study included a total of 183 children, comprising 116 (63.4%) males and 67 (36.6%) females with a mean age of 61.3 ± 34.3 months. While mesenteric lymphadenitis (n = 7) was determined as the most common lesion in cases where a pathologic lead point was detected (7.6%), Meckel’s diverticulum was observed in four patients, polyps in two patients, and an involvement associated with Henoch Schönlein Vasculitis in one patient. Pneumatic reduction procedure was applied in 154 (84.1%) patients and successful results were obtained in 115 (74.7%) patients, while surgical intervention was required in 39 (25.3%) patients.While frequency of admission to direct surgery following the failure of pneumatic reduction in children under the age of two years was determined to be higher than the frequency of healing, the successful pneumatic reduction and admission to direct surgery rates in children between the ages of 0-4 years was found to be significantly higher than those in other age groups (p < 0.001). The pneumatic reduction success rate was determined to decrease significantly in children aged ≥6 years (p < 0.001). The mean hospitalization duration of the patients who underwent surgery after pneumatic reduction (five days) was determined to be significantly longer compared to that of the patients who underwent direct surgery and for whom a successful pneumatic reduction was ensured (p = 0.001 and p = 0.008, respectively).ConclusionFluoroscopy-guided pneumatic reduction has a high success rate and is still one of the first option methods in the treatment of idiopathic intussusception. The application of the method under operating room conditions is more appropriate for patient safety. It is considered that the non-operative reduction success may increase with the detailed ...

Serum tRNA-derived fragments as potential biomarkers in children with acute intussusception.

“…In clinical practice, the diagnosis of pediatric intussusception is mainly based on a combination of clinical symptoms and examinations from ultrasound (US) imaging, computed tomography (CT), or air enema [ 7 ]. Early detection of pediatric intussusception and associated intestinal I/R can improve prognosis and treatment efficacy [ 8 , 9 ]. Until now, there has been no clinical biomarker for early diagnosis of pediatric intussusception and associated intestinal I/R.…”

Serum tRNA-Derived Fragments as Potential Biomarkers in Children with Acute Intussusception

“…In the clinical practice, the diagnosis of pediatric intussusception is mainly based on a combination of clinical symptoms and examinations from ultrasound (US) imaging, computed tomography (CT), or air enema [7]. Early detection of pediatric intussusception and associated intestinal I/R can improve prognosis and treatment e cacy [8,9]. Until now, there has been no clinical biomarker for early diagnosis of pediatric intussusception and associated intestinal I/R.…”