“…6,10,12,13,20,23,26 These data are in accordance with the progression of venous disease where reflux advances from the tributaries and accessory saphenous veins to the saphenous trunks or develops in new locations. 6,12,15,18,19,24,27 Patients with skin damage have a higher prevalence of junctional involvement. It could be assumed that patients with primary CVD have more longstanding disease compared to CEAP classes 2 and 3.…”