Selection of solid-state excipients for simvastatin dosage forms through thermal and nonthermal techniques

Abstract

The importance of developing new pharmaceutical final formulations is nowadays well known. In this paper, we present the study of compatibility between bioactive antihyperlipidemic agent simvastatin and eight currently used pharmaceutical excipients for developing solid dosage forms, namely starch, microcrystalline cellulose, lactose monohydrate, polyvinylpyrrolidone, colloidal silica, talc, magnesium citrate and sorbitol. The compatibility investigations were carried out under ambient temperature by FTIR spectroscopy studies and PXRD patterns and then completed by the use of thermal analysis (TG/DTG/HF) data to study the influence of temperature over stability of binary mixtures.

Sodium alendronate used in bone treatment

“…Starch is frequently used as an excipient and often a similar thermal behavior like the one of MCel is observed when used in a mixture with a pharmaceutical agent [13][14][15]. Indeed, a similar structure, a polysaccharide molecule, leads to a compatible thermodegradation in the same temperature range, and this is obvious by comparison of the HF curves corresponding to MCel in Fig.…”

“…Therefore, by the following discussions, the HF signal of the binary mixtures studied will be analyzed in respect with the signal recorded for A at 270°C. Talc and SiO 2 are known as highly thermal and chemically stable compounds, and therefore they are used as ''inert standards'' in compatibility studies [15,16]. By investigating Figs.…”

“…According to [5] and some of our previous papers [11][12][13][14][15][16], the thermal behavior of these binary mixtures was studied under non-isothermal conditions in order to detect the thermally induced interactions.…”

The Protective Effect of HDL-Cholesterol in Patients with Essential Hypertension

“…Some studies were also carried out in the analysis of compounds used in the therapy of high cholesterol levels [13][14][15][16][17][18], by instrumental techniques, such as thermal analysis and spectroscopic techniques [19][20][21][22][23][24][25][26][27][28][29].…”

The Effects of Hg2+ on Endothelial Function in Electronic Cigarette Smokers with Coronary Artery Disease

“…Even though toxic chemicals like heavy metals, phenols and polycyclic aromatic hydrocarbons that are carcinogenic were not detected, traces of mercury (0.17 ng per EC), formaldehyde and acetaldehyde were found [8]. Regarding the physicochemical stability and characterisation of tobacco and related products, several instrumental methods were employed, including thermal stability and kinetic degradation [9,10], by well-known methodologies, according to literature published for diverse compounds, including bioactive or potentially bioactive compounds [11][12][13][14][15][16][17][18][19][20][21]. Also, studies including the analysis of the smoke and its composition [22] were carried out.…”