Selection of surrogate marker genes in primary central nervous system lymphomas for radio-chemotherapy by DNA array analysis of gene expression profiles

Yamanaka, Ryuya; Akutagawa, Shigeru; Taguchi, Fumiko; Yajima, Naoki; Tsuchiya, Naoto; Uzuka, Takeo; Morii, Ken; Takahashi, Hideaki; Tanaka, Ryuichi; Saijo, Nagahiro; Nishio, Kenji

doi:10.3892/ijo.23.4.913

Cited by 2 publications

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“…Ninguna de las clasificaciones existentes de los linfomas sistémicos incluye específicamente a los linfomas primarios del SNC y no existe una clasificación específica de los mismos. Una clasificación basada en características genéticas (marcadores pronósticos), podría tener utilidad clínica en cuanto a pronóstico y tratamiento 44,45 .…”

Section: Pronósticounclassified

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Linfoma cerebral primario: revisión bibliográfica y experiencia en el Hospital de Navarra en los últimos 5 años (2000-2004)

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Gorosquieta

et al. 2005

Anales Sis San Navarra

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Primary cerebral lymphoma (Primary CNS Lymphoma, PCNSL) is an aggressive non-Hodgkin lymphoma that originates in the central nervous system without evidence of lymphoma in any other localization at the time of diagnosis. Primary cerebral lymphomas are less well-known and are characterized than their homologues the systemic lymphomas, as they are an entity whose frequency was scarce until a few decades ago. However, the great rise in incidence that this pathology has undergone over the last three decades, and which is still unexplained, makes more studies necessary to better understand the etiopathology of this entity. Thanks to the new systems of treatment, the prognosis of this pathology has improved significantly in recent years. Nonetheless, treatment of primary cerebral lymphoma continues to give rise to numerous controversies at present due to its high neurotoxicity in patients over 60 years of age, a group of patients frequently affected by this pathology. To resolve these and other questions it is necessary to deep in the study of primary cerebral lymphoma and to carry out high quality clinical trials.

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Section: Pronósticounclassified

“…Una clasificación basada en características genéticas (marcadores pronósticos), podría tener utilidad clínica en cuanto a pronóstico y tratamiento 45 .…”

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Linfoma cerebral primario: revisión bibliográfica y experiencia en el Hospital de Navarra en los últimos 5 años (2000-2004)

Zazpe

Llano

Gorosquieta

et al. 2005

Anales Sis San Navarra

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“…The expression of FN1 , in addition to LMO2 , BCL2 , BCL6 , CCND2 (cyclin D2), and SCYA3 is effective in estimating OS using polymerase chain reaction and microarray in DLBCL [ 46 ]. In addition, laminin receptor 2 is a PCNSL-specific gene detected by principal component analysis on DNA arrays in a small sample size [ 47 ]. Furthermore, genes with altered promoter DNA methylation can be used as biomarkers for cancer detection and assessment of prognosis.…”

Section: Discussionmentioning

confidence: 99%

“…DLBCL [46]. In addition, laminin receptor 2 is a PCNSL-specific gene detected by principal component analysis on DNA arrays in a small sample size [47]. Furthermore, genes with altered promoter DNA methylation can be used as biomarkers for cancer detection and assessment of prognosis.…”

Section: Plos Onementioning

confidence: 99%

Survival prediction based on the gene expression associated with cancer morphology and microenvironment in primary central nervous system lymphoma

et al. 2021

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Dysregulation of cell morphology and cell-cell interaction results in cancer cell growth, migration, invasion, and metastasis. Besides, a balance between the extracellular matrix (ECM) and matrix metalloprotease (MMP) is required for cancer cell morphology and angiogenesis. Here, we determined gene signatures associated with the morphology and microenvironment of primary central nervous system lymphoma (PCNSL) to enable prognosis prediction. Next-generation sequencing (NGS) on 31 PCNSL samples revealed gene signatures as follows: ACTA2, ACTR10, CAPG, CORO1C, KRT17, and PALLD in cytoskeleton, CDH5, CLSTN1, ITGA10, ITGAX, ITGB7, ITGA8, FAT4, ITGAE, CDH10, ITGAM, ITGB6, and CDH18 in adhesion, COL8A2, FBN1, LAMB3, and LAMA2 in ECM, ADAM22, ADAM28, MMP11, and MMP24 in MMP. Prognosis prediction formulas with the gene expression values and the Cox regression model clearly divided survival curves of the subgroups in each status. Furthermore, collagen genes contributed to gene network formation in glasso, suggesting that the ECM balance controls the PCNSL microenvironment. Finally, the comprehensive balance of morphology and microenvironment enabled prognosis prediction by a combinatorial expression of 8 representative genes, including KRT17, CDH10, CDH18, COL8A2, ADAM22, ADAM28, MMP11, and MMP24. Besides, these genes could also diagnose PCNSL cell types with MTX resistances in vitro. These results would not only facilitate the understanding of biology of PCNSL but also consider targeting pathways for anti-cancer treatment in personalized precision medicine in PCNSL.

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Selection of surrogate marker genes in primary central nervous system lymphomas for radio-chemotherapy by DNA array analysis of gene expression profiles

Cited by 2 publications

References 0 publications

Linfoma cerebral primario: revisión bibliográfica y experiencia en el Hospital de Navarra en los últimos 5 años (2000-2004)

Linfoma cerebral primario: revisión bibliográfica y experiencia en el Hospital de Navarra en los últimos 5 años (2000-2004)

Survival prediction based on the gene expression associated with cancer morphology and microenvironment in primary central nervous system lymphoma

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