Selection of treatment for corpus cancer

Gusberg, S.B.; Jones, Herbert C.; Tovell, Harold M.M.

doi:10.1016/0002-9378(60)90141-1

Cited by 62 publications

(17 citation statements)

References 21 publications

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“…5,20,21 In most of them, tumor size was evaluated according to gross inspection of hysterectomy specimens. Schink et al 6 reported that average tumor diameter greater than 2 cm in pathologic specimen independently predicted lymph node metastasis and survival.…”

Section: Discussionmentioning

confidence: 99%

“…4 Tumor size has been reported to have a prognostic impact in endometrial cancer since 1960s. 5 Although International Federation of Gynecology and Obstetrics (FIGO) staging system for endometrial cancer does not include tumor size measurement, relationship of large macroscopic tumor size in hysterectomy specimen and poor survival has long been known. 6,7 Some recent publications including large cohorts from Japan and Korea focused on prognostic value of tumor volume index (product of maximum three diameters) based on preoperative magnetic resonance (MR) imaging in predicting lymph node metastasis and the endometrial cancer prognosis.…”

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confidence: 99%

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Preoperative Magnetic Resonance Volumetry inPredicting Myometrial Invasion,Lymphovascular SpaceInvasion, and Tumor Grade

Şahin

Sarıoğlu

Bağci

et al. 2018

International Journal of Gynecological Cancer

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Preoperative Magnetic Resonance Volumetry inPredicting Myometrial Invasion,Lymphovascular SpaceInvasion, and Tumor Grade

Şahin

Sarıoğlu

Bağci

et al. 2018

International Journal of Gynecological Cancer

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“…However, tumor size was reported to be an indicator of prognosis in patients with endometrial cancer as early as 1960 by Gusberg et al (42), who demonstrated a worse prognosis when the uterus measured more than 10 cm. This fairly imprecise estimate was redefined by Schink et al (26), who evaluated tumor size as the average tumor diameter measured in the pathologic specimen.…”

Section: Discussionmentioning

confidence: 99%

Endometrial Cancer: Combined MR Volumetry and Diffusion-weighted Imaging for Assessment of Myometrial and Lymphovascular Invasion and Tumor Grade

Nougaret¹,

Reinhold²,

AlSharif³

et al. 2015

Radiology

146

114

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Purpose:To investigate magnetic resonance (MR) volumetry of endometrial tumors and its association with deep myometrial invasion, tumor grade, and lymphovascular invasion and to assess the value of apparent diffusion coefficient (ADC) histographic analysis of the whole tumor volume for prediction of tumor grade and lymphovascular invasion. Materials and Methods:The institutional review board approved this retrospective study; patient consent was not required. Between May 2010 and May 2012, 70 women (mean age, 64 years; range, 24-91 years) with endometrial cancer underwent preoperative MR imaging, including axial oblique and sagittal T2-weighted, dynamic contrast material-enhanced, and diffusion-weighted imaging. Volumetry of the tumor and uterus was performed during the six sequences, with manual tracing of each section, and the tumor volume ratio (TVR) was calculated. ADC histograms were generated from pixel ADCs from the whole tumor volume. The threshold of TVR associated with myometrial invasion was assessed by using receiver operating characteristic curves. An independent sample Mann Whitney U test was used to compare differences in ADCs, skewness, and kurtosis between tumor grade and the presence of lymphovascular invasion. Results:No significant difference in tumor volume and TVR was found among the six MR imaging sequences (P = .95 and .86, respectively). A TVR greater than or equal to 25% allowed prediction of deep myometrial invasion with sensitivity of 100% and specificity of 93% (area under the curve, 0.96; 95% confidence interval: 0.86, 0.99) at axial oblique diffusion-weighted imaging. A TVR of greater than or equal to 25% was associated with grade 3 tumors (P = .0007) and with lymphovascular invasion (P , .0001).There was no significant difference in the ADCs between grades 1 and 2 tumors (P . .05). The minimum, 10th, 25th, 50th, 75th, and 90th percentile ADCs were significantly lower in grade 3 tumors than in grades 1 and 2 tumors (P , .02). Conclusion:The combination of whole tumor volume and ADC can be used for prediction of tumor grade, lymphovascular invasion, and depth of myometrial invasion.q RSNA, 2015

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“…4 Tumor size (TS) has been suggested to be an indicator of prognosis in endometrial cancer as early as 1960, when it was found that a uterus sounding greater than 10 cm was associated with worse prognosis. 5 This fairly imprecise estimate was redefined, and TS was independently associated with risk of lymph node metastasis (4% for tumors G2 cm or 15% for tumors 92 cm) and was a significant prognostic factor for survival (98% vs 84%). 6 Other researchers have shown TS greater than 2 cm to be associated with extrauterine disease, nodal metastasis, and recurrence, but only in univariate analyses.…”

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confidence: 99%