Selection of treatment in squamous carcinoma of the floor of the mouth

Flynn, Michael B.; Mullins, Fitzhugh; Moore, Condict

doi:10.1016/s0002-9610(73)80033-9

Cited by 28 publications

(3 citation statements)

References 4 publications

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“…Some of their patients had received preoperative radiation as part of their overall treatment. In other data published by this group, the primary site control rate obtained after initial treatment with either surgery (77%) or irradiation (84%) for Stages I and I1 lesions of the floor of mouth was comparable to their control rate in their marginal resection group (75%) [12].…”

Section: Discussionsupporting

confidence: 47%

Mandible preservation in the treatment of cancer of the floor of the mouth

Beecroft

Sako

Razack

et al. 1982

Journal of Surgical Oncology

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A segmental anterior mandibulectomy causes severe functional disability and cosmetic problems. Many methods of reconstruction have been used but none of these procedures provides the ideal solution. There has been increasing interest in the possibility of preserving a portion of the anterior mandibular arch and still carrying out an adequate surgical excision to control the primary tumor. Over a 15-year period, 251 patients with cancer of the floor of mouth were seen and treated at Roswell Park Memorial Institute. Of this group, 34 patients underwent a marginal mandibular resection as part of their curative surgical treatment. The complication rate was acceptable and the 5-year determinate survival rate was 84%. The local control rate was excellent with only one patient developing an intraoral recurrence which was successfully treated with radiation. It is felt that these data support the theory that conservative mandibular surgery can be carried out in selected cases without jeopardizing the concept of a good cancer operation.

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Section: Discussionsupporting

confidence: 47%

Mandible preservation in the treatment of cancer of the floor of the mouth

Beecroft

Sako

Razack

et al. 1982

Journal of Surgical Oncology

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“…From our data ''localized'' stage 1-11 squamous cell carcinoma of the floor of the mouth and mobile tongue is indeed a misnomer leading to complacent treatment of these lesions. These cancers, when treated by unimodality therapy, should have a 60-75% five-year survival [Fayos, 1972;Flynn et al, 1973;Sako et al, 19711, whether treated by surgery or radiation [Helfrich et al, 19721 . Some patients respond poorly t o local therapy alone [Million, 1974;Shah et al, 19761, with a subsequent aggressive tumor behavior [Marchetta et al, in press] .…”

Section: Discussionmentioning

confidence: 99%

“Localized” carcinoma of the mobile tongue and floor of the mouth—a lesion frequently misjudged and undertreated

McColl

Horwood

1978

Journal of Surgical Oncology

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A retrospective study of 74 cases of cancer of the mobile tongue and floor of the mouth, diagnosed between 1949 and 1975, with a two-year minimum follow-up was undertaken. The lesions were TNM staged, stages I and II accounting for 56 cases (76%) and stages III and IV accounting for 18 cases (24%). The analysis was restricted to the "localized" stage I and stage II lesions. In this group failure occurred in 31 patients, or 55% of the group. Failure at the primary site accounted for 10 of the failures, failure at both primary and cervical lymph nodes accounted for 14, and failure at cervical lymph nodes only accounted for 7 of the failures. The treatment for these "localized" lesions was then analyzed for modality, adequacy, presence or absence of planning failure, and survival. The results indicate the lethal nature of this lesion when inadequately treated and strongly suggest more extensive use of prophylactic therapy to the cervical lymph nodes.

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“…It should be added that in such cases there is a probable advantage in pre-operative irradiation up to 4,000 rads to the primary lesion and neck fields (Jesse, 1972;Flynn et at., 1973). It is also found that the alternative of pre-operative cytotoxic chemotherapy (intravenous short duration high dosage Methotrexate or combination chemotherapy) in two or three courses with an interval of 3 weeks before surgery, often reduces the tumour bulk more rapidly.…”

Section: Extensive Lesionsmentioning

confidence: 99%