Selective Absorption of Optical Antipodes by Proteins

Bradley, William; Brindley, R. A.

doi:10.1038/173312b0

Cited by 3 publications

(1 citation statement)

References 4 publications

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“…High affinity for wool does not mean the same for us as "selective absorption." An example: Bradley, 1951, has shown the selective absorption of one of the optical antipodes by wool from an aqueous or alcoholic solution containing both of the optical antipodes of resolvable acids. Pentaquine, displays an affinity of 3.6 X 10" 2 mMoles per 1 gm.…”

Section: :Imentioning

confidence: 99%

Molecular structure and functional activity of nerve cells: a symposium organized by the American Institute of Biological Sciences and sponsored by the Office of Naval Research; held in Washington, D.C., June 3-4, 1955

Grenell¹,

Mullins²

1956

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In the past several years considerable progress has been made mThe-rfa*rTfication of the problems of neural activity and of a host of ancillary physical and chemical events in living cells. Investigators in many fields from biology through chemistry, physics, mathematics, philosophy and psychology, have contributed new observations and concepts. They have drawn upon one another's knowledge and experience in attempts to refine existing experimental techniques and arrive at more accurate estimates of the properties and interrelationships of particular structures, mechanisms and processes at levels from the grossest complexity of the organism in toto to the most microscopic and sub-microscopic complexities of molecular structure and orientation. Consequently, it was felt that there was need for some discussion of stimulusresponse problems not only insofar as existing data are concerned, but more particularly in relation to whether or not present experimentation and concept are leading to better understanding of the crucial problems underlying neuronal behavior. The existence of certain transient phenomena in nerve cells forms the basis for their physiology and confronts the investigator with certain sorts of problems which, although they are not unique to this field, are representative of the difficulties involved in relating biological function to molecular interaction.

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Section: :Imentioning

confidence: 99%

Molecular structure and functional activity of nerve cells: a symposium organized by the American Institute of Biological Sciences and sponsored by the Office of Naval Research; held in Washington, D.C., June 3-4, 1955

Grenell¹,

Mullins²

1956

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Stereochemie und biologische Aktivität

Beckett¹

1960

Angewandte Chemie

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Die Bedeutung sterischer Faktoren fur die enzymatische Aktivitat, den Stoffwechsel und die Wirkung von Arzneimitteln wird un einigen d e r vielen bekannten Beispiele gezeigt. O h n e Zweifel ist die dreidimensionale Struktur d e r umgesetzten Stoffe fur biologische Reaktionen von besonderer Wichtigkeit. Do Arzneimittel solche Reaktionen storen o d e r fordern, ist es entscheidend, ihren raumlichen Bau zu kennen und zu erfahren, wie weit e r ihre Wirkung beeinflufit, urn Stoffe mit bestimmter biologischer Aktivitat synthetisieren zu konnen. *) oberarbeiteter rind ergattzter Auszug eiiier Arbeit, die in: E . Jirckrr-: Fortschritte der Arzneimittelforschung, Birkhauser Verlag, Basel und S t u t t g a r t 1959, Bd. I , S. 456, erschienen ist. Wir danken dem Herausgeber und dem Verlag f u r die Erlaubnis Z u n i teilweisen Nachdruck. a b rn Abb. 2. Orientierung zweier Stereoisotnere zu einer Kezeptor-Oberflache 686

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Stereochemical Factors in Biological Activity

Beckett¹

1959

Fortschritte Der Arzneimittelforschung / Progress in Drug Research / Progrès Des Recherches Pharmaceutiques

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Selective Absorption of Optical Antipodes by Proteins

Cited by 3 publications

References 4 publications

Molecular structure and functional activity of nerve cells: a symposium organized by the American Institute of Biological Sciences and sponsored by the Office of Naval Research; held in Washington, D.C., June 3-4, 1955

Molecular structure and functional activity of nerve cells: a symposium organized by the American Institute of Biological Sciences and sponsored by the Office of Naval Research; held in Washington, D.C., June 3-4, 1955

Stereochemie und biologische Aktivität

Stereochemical Factors in Biological Activity

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