1998
DOI: 10.1016/s0008-6363(98)00112-6
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Selective activation of adenosine A3 receptors with N6-(3-chlorobenzyl)-5′-N-methylcarboxamidoadenosine (CB-MECA) provides cardioprotection via KATP channel activation

Abstract: CB-MECA is a novel 100-fold A3 receptor-selective agonist which should prove useful for elucidating A3-dependent mechanisms in the rabbit heart. Selective stimulation of adenosine A3 receptors with CB-MECA reduces myocardial ischemia/reperfusion injury via a mechanism which involves activation of KATP channels.

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Cited by 69 publications
(65 citation statements)
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“…In cardiac cells, A 3 AR agonists induce protection through the activation of K ATP channels 30 . RhoA-phospholipase D1 signalling has been demonstrated to mediate the antiischaemic effect of A 3 ARs 31 .…”
Section: Ar Signalling Pathways and Regulationmentioning
confidence: 99%
See 1 more Smart Citation
“…In cardiac cells, A 3 AR agonists induce protection through the activation of K ATP channels 30 . RhoA-phospholipase D1 signalling has been demonstrated to mediate the antiischaemic effect of A 3 ARs 31 .…”
Section: Ar Signalling Pathways and Regulationmentioning
confidence: 99%
“…Adenosine is released in large amounts during myocardial ischaemia, resulting in effective pre-conditioning in cardiomyocytes through the activation of A 1 and A 3 ARs [29][30][31]68 . Administration of a synthetic AR agonist to activate either or both of these receptors might therefore be beneficial to the survival of the ischaemic heart.…”
Section: Ischaemiamentioning
confidence: 99%
“…In dog, for example, infarct size is either increased or unaffected by glibenclamide (31, 292). In some rabbit studies, glibenclamide increased postischemic infarct size (567, 805), whereas other studies reported no effect (812,813,854). In rats, glibenclamide has no effect on infarct size (152, 647), increases infarct size at higher concentrations that are associated with changes in blood glucose levels (511), or may even decrease infarct size in some studies (203).…”
Section: D) Do Species Differences Exist?mentioning
confidence: 99%
“…Earlier research focused on the role of the A 1 adenosine receptor (A 1 AR); however, recent evidence suggests that the A 3 adenosine receptor (A 3 AR) may also afford cardioprotection (29,48,50,63). Both A 1 AR and A 3 AR activation may be important triggers of both early preconditioning (EPC) and delayed preconditioning (DPC) (4, 58, 67); however, separate signaling pathways may be involved (38).…”
mentioning
confidence: 99%
“…Cohen et al (7) observed that protection afforded by adenosine receptor activation was independent of both mitoK ATP channel opening and ROS in isolated rabbit hearts, whereas other investigators reported (19,63) that mitoK ATP may be integral to the cardioprotective effects of adenosine.…”
mentioning
confidence: 99%