Selective Activation of Endoplasmic Reticulum Stress by Reactive-Oxygen-Species-Mediated Ochratoxin A-Induced Apoptosis in Tubular Epithelial Cells

Khoi, Chong-Sun; Lin, Yu‐Wen; Chen, Jia-Huang; Liu, Biing-Hui; Lin, Tzu-Yu; Hung, Kuan‐Yu; Chiang, Chih‐Kang

doi:10.3390/ijms222010951

Cited by 8 publications

(1 citation statement)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Fumonisin B1 exposure induces apoptosis of human kidney tubular epithelial cells by regulating PTEN/PI3K/AKT signaling pathway via disrupting lipid raft formation ( 19 ). OTA induced apoptosis through selective endoplasmic reticulum (ER) stress activation in HK-2 cells ( 20 ). In mice, PINK1/Parkin-mediated mitophagy protects against AFB1-induced kidney injury ( 21 ).…”

Section: Systemic Toxicity Of Mycotoxinsmentioning

confidence: 99%

Protective and detoxifying effects conferred by selenium against mycotoxins and livestock viruses: A review

Fang

Liu

2022

Front. Vet. Sci.

View full text Add to dashboard Cite

Animal feed can easily be infected with molds during production and storage processes, and this can lead to the production of secondary metabolites, such as mycotoxins, which eventually threaten human and animal health. Furthermore, livestock production is also not free from viral infections. Under these conditions, the essential trace element, selenium (Se), can confer various biological benefits to humans and animals, especially due to its anticancer, antiviral, and antioxidant properties, as well as its ability to regulate immune responses. This article reviews the latest literature on the antagonistic effects of Se on mycotoxin toxicity and viral infections in animals. We outlined the systemic toxicity of mycotoxins and the primary mechanisms of mycotoxin-induced toxicity in this analysis. In addition, we pay close attention to how mycotoxins and viral infections in livestock interact. The use of Se supplementation against mycotoxin-induced toxicity and cattle viral infection was the topic of our final discussion. The coronavirus disease 2019 (COVID-19) pandemic, which is currently causing a health catastrophe, has altered our perspective on health concerns to one that is more holistic and increasingly embraces the One Health Concept, which acknowledges the interdependence of humans, animals, and the environment. In light of this, we have made an effort to present a thorough and wide-ranging background on the protective functions of selenium in successfully reducing mycotoxin toxicity and livestock viral infection. It concluded that mycotoxins could be systemically harmful and pose a severe risk to human and animal health. On the contrary, animal mycotoxins and viral illnesses have a close connection. Last but not least, these findings show that the interaction between Se status and host response to mycotoxins and cattle virus infection is crucial.

show abstract

Section: Systemic Toxicity Of Mycotoxinsmentioning

confidence: 99%

Protective and detoxifying effects conferred by selenium against mycotoxins and livestock viruses: A review

Fang

Liu

2022

Front. Vet. Sci.

View full text Add to dashboard Cite

show abstract

The nephrotoxin ochratoxin a impairs resilience of energy homeostasis of human proximal tubule cells

2023

View full text Add to dashboard Cite

Despite a long history of research, the mode of action of the mycotoxin ochratoxin A (OTA) is still not clear. Based on our observation that OTA-exposed cells consume more glucose and produce more lactate than control cells, with this study, we want to suggest another possible mode of action of OTA, involving cellular metabolism and mitochondria. We exposed human proximal tubule cells (HK2 cells) to OTA and studied its influence on mitochondrial performance as well as on the expression of energy homeostasis-involved routing proteins (AMPK and TXNIP) and on glucose transporting and metabolizing proteins. OTA reduced the capacity of mitochondria to increase their oxygen consumption rate forcing the cells to switch to the ineffective anaerobic glycolysis which demands higher glucose availability. The higher glucose demand is met by augmented cellular glycogen degradation and increased glucose uptake capabilities by increasing glucose transporter expression. We conclude that OTA exposure leads to impaired mitochondria, which forces the cells to alter their metabolism in order to ensure energy supply. We suggest to consider a possible effect of OTA on metabolism and mitochondria and to have a closer look on OTA-induced changes in the metabolome as possible additional players in OTA toxicity.

show abstract

New perspective on mechanism in muscle toxicity of ochratoxin A: Model of juvenile grass carp (Ctenopharyngodon idella)

Zhao,

Liu,

Feng

et al. 2023

Aquatic Toxicology

View full text Add to dashboard Cite

Selective Activation of Endoplasmic Reticulum Stress by Reactive-Oxygen-Species-Mediated Ochratoxin A-Induced Apoptosis in Tubular Epithelial Cells

Cited by 8 publications

References 43 publications

Protective and detoxifying effects conferred by selenium against mycotoxins and livestock viruses: A review

Protective and detoxifying effects conferred by selenium against mycotoxins and livestock viruses: A review

The nephrotoxin ochratoxin a impairs resilience of energy homeostasis of human proximal tubule cells

New perspective on mechanism in muscle toxicity of ochratoxin A: Model of juvenile grass carp (Ctenopharyngodon idella)

Contact Info

Product

Resources

About