ObjectivesTo investigate the effect of cumulative doses of radiation on the pushout bond strength (BS) of a universal resin cement used in the self‐etch (SE) and self‐adhesive (SA) modes to the intraradicular dentin.Materials and MethodsForty‐eight human teeth were distributed into three groups (n = 16) according to the radiation therapy dose (RT): NoRT (no‐radiotherapy), 70RT (70 Gy), and 70 + 70RT (70 Gy + 70 Gy). The teeth were redistributed into two subgroups (n = 8), according to the adhesive mode: SE (NoRT‐SE, 70RT‐SE, and 70 + 70RT‐SE) and SA (NoRT‐SA, 70RT‐SA, and 70 + 70RT‐SA). Data were statistically compared after BS test (ANOVA, Tukey's post hoc test, and Fisher's exact test).ResultsIn the SA mode, BS was significantly higher in nonirradiated teeth compared with 70RT and 70 + 70RT (p < 0.0001). There were no significant differences between SE and SA modes in nonirradiated teeth (p = 0.14). In the 70RT group, SE mode increased BS compared with SA mode (p < 0.0001). Most specimens had adhesive and mixed failures in SA and SE modes, respectively.ConclusionsThe universal resin cement in the SE mode had greater BS to the irradiated dentin. When teeth were re‐irradiated, the universal resin cement had similar performance in terms of BS, regardless of the adhesive approach.Clinical SignificanceThere is no research establishing a correlation between radiotherapy and its impact on the BS of a universal resin cement used in SE and SA modes to intraradicular dentin.