Selective and caspase-independent cytotoxicity of bioactive glasses towards giant cell tumor of bone derived neoplastic stromal cells but not to bone marrow derived stromal cells

Westhauser, Fabian; Arango‐Ospina, Marcela; Losch, Sarina; Wilkesmann, Sebastian; Lehner, Burkhard; Ali, Muhammad; Boccaccını, Aldo R.; Fellenberg, Jörg

doi:10.1016/j.biomaterials.2021.120977

Cited by 13 publications

(20 citation statements)

References 50 publications

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“…As already shown for other GCTB cell lines in a previous study also the viability of the newly isolated GCTSCs was significantly decreased in a time- and concentration dependent manner after BG treatment [ 29 ]. The strongest effects were induced by 45S5-BG that was already visible after 24 h of treatment.…”

Section: Resultssupporting

confidence: 70%

“…The BGs underwent a sintering process that resembles the heat treatment necessary to shape the materials into 3D structures. The used sintering programs were 1.5 h at 690 °C for ICIE16-BG and 3Zn-BG and 2 h at 1050 °C for 45S5-BG, partial crystallization of the particles was induced as was demonstrated in a previous study [ 29 ]. The morphology of the BG particles was characterized by scanning electron microscopy (SEM, Auriga, Carl-Zeiss, Germany) with an accelerating voltage of 1.5 kV.…”

Section: Methodsmentioning

confidence: 97%

“…The chemical compositions of the BGs used in this study are presented in Table 1 . The glasses were produced by the melt-quenching method, as detailed elsewhere [ 29 ]. The BGs underwent a sintering process that resembles the heat treatment necessary to shape the materials into 3D structures.…”

Section: Methodsmentioning

confidence: 99%

“…For example, Yan and co-workers attributed BG-mediated cytotoxicity to an increase in membrane fluidity caused by the ionic dissolution products (mainly Si-ions) from BGs [ 28 ]. However, there is increasing evidence that the impact of local pH alterations as well as the presence of the ionic dissolution products on cell viability might be overestimated as also shown in a recent study conducted by our group [ 29 ]. In this previous study we identified a selective cytotoxic effect of BGs towards the neoplastic stromal cell population of GCTB (GCTSC) whilst the viability of bone marrow derived stromal cells (BMSC) remained unaffected or was even enhanced in the presence of BGs.…”

Section: Introductionmentioning

confidence: 92%

“…In this previous study we identified a selective cytotoxic effect of BGs towards the neoplastic stromal cell population of GCTB (GCTSC) whilst the viability of bone marrow derived stromal cells (BMSC) remained unaffected or was even enhanced in the presence of BGs. This effect was independent from the BG induced pH-shift and dissolution products, but it was shown to be related to the direct contact of cells with BGs [ 29 ]. Based on the observed properties, we hypothesized that BGs might be promising biomaterials that could be used for the reduction of GCTB recurrence rates through killing of tumor cells that remained after surgery and the simultaneous promotion of BMSC-mediated bone regeneration due to their known osteogenic properties.…”

Section: Introductionmentioning

confidence: 99%

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Bioactive glass selectively promotes cytotoxicity towards giant cell tumor of bone derived neoplastic stromal cells and induces MAPK signalling dependent autophagy

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et al. 2022

Bioactive Materials

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Section: Resultssupporting

confidence: 70%

Section: Methodsmentioning

confidence: 97%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Bioactive glass selectively promotes cytotoxicity towards giant cell tumor of bone derived neoplastic stromal cells and induces MAPK signalling dependent autophagy

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Nanostructured bioactive glasses: A bird's eye view on cancer therapy

Kargozar

Moghanian

Rashvand

et al. 2023

WIREs Nanomed Nanobiotechnol

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Bioactive glasses (BGs) arewell known for their successful applications in tissue engineering and regenerative medicine. Recent experimental studies have shown their potential usability in oncology, either alone or in combination with other biocompatible materials, such as biopolymers. Direct contact with BG particles has been found to cause toxicity and death in specific cancer cells (bone‐derived neoplastic stromal cells) in vitro. Nanostructured BGs (NBGs) can be doped with anticancer elements, such as gallium, to enhance their toxic effects against tumor cells. However, the molecular mechanisms and intracellular targets for anticancer compositions of NBGs require further clarification. NBGs have been successfully evaluated for use in various well‐established cancer treatment strategies, including cancer hyperthermia, phototherapy, and anticancer drug delivery. Existing results indicate that NBGs not only enhance cancer cell death, but can also participate in the regeneration of lost healthy tissues. However, the application of NBGs in oncology is still in its early stages, and numerous unanswered questions must be addressed. For example, the impact of the composition, biodegradation, size, and morphology of NBGs on their anticancer efficacy should be defined for each type of cancer and treatment strategy. Moreover, it should be more clearly assessed whether NBGs can shrink tumors, slow/stop cancer progression, or cure cancer completely. In this regard, the use of computational studies (in silico methods) is highly recommended to design the most effective glass formulations for cancer therapy approaches and to predict, to some extent, the relevant properties, efficacy, and outcomes.This article is categorized under: Implantable Materials and Surgical Technologies > Nanomaterials and Implants Implantable Materials and Surgical Technologies > Nanotechnology in Tissue Repair and Replacement Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease

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Bioactive glasses incorporating less-common ions to improve biological and physical properties

Pantulap

Arango‐Ospina

Boccaccını

2021

J Mater Sci: Mater Med

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Bioactive glasses (BGs) have been a focus of research for over five decades for several biomedical applications. Although their use in bone substitution and bone tissue regeneration has gained important attention, recent developments have also seen the expansion of BG applications to the field of soft tissue engineering. Hard and soft tissue repair therapies can benefit from the biological activity of metallic ions released from BGs. These metallic ions are incorporated in the BG network not only for their biological therapeutic effects but also in many cases for influencing the structure and processability of the glass and to impart extra functional properties. The “classical” elements in silicate BG compositions are silicon (Si), phosphorous (P), calcium (Ca), sodium (Na), and potassium (K). In addition, other well-recognized biologically active ions have been incorporated in BGs to provide osteogenic, angiogenic, anti-inflammatory, and antibacterial effects such as zinc (Zn), magnesium (Mg), silver (Ag), strontium (Sr), gallium (Ga), fluorine (F), iron (Fe), cobalt (Co), boron (B), lithium (Li), titanium (Ti), and copper (Cu). More recently, rare earth and other elements considered less common or, some of them, even “exotic” for biomedical applications, have found room as doping elements in BGs to enhance their biological and physical properties. For example, barium (Ba), bismuth (Bi), chlorine (Cl), chromium (Cr), dysprosium (Dy), europium (Eu), gadolinium (Gd), ytterbium (Yb), thulium (Tm), germanium (Ge), gold (Au), holmium (Ho), iodine (I), lanthanum (La), manganese (Mn), molybdenum (Mo), nickel (Ni), niobium (Nb), nitrogen (N), palladium (Pd), rubidium (Rb), samarium (Sm), selenium (Se), tantalum (Ta), tellurium (Te), terbium (Tb), erbium (Er), tin (Sn), tungsten (W), vanadium (V), yttrium (Y) as well as zirconium (Zr) have been included in BGs. These ions have been found to be particularly interesting for enhancing the biological performance of doped BGs in novel compositions for tissue repair (both hard and soft tissue) and for providing, in some cases, extra functionalities to the BG, for example fluorescence, luminescence, radiation shielding, anti-inflammatory, and antibacterial properties. This review summarizes the influence of incorporating such less-common elements in BGs with focus on tissue engineering applications, usually exploiting the bioactivity of the BG in combination with other functional properties imparted by the presence of the added elements.

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Selective and caspase-independent cytotoxicity of bioactive glasses towards giant cell tumor of bone derived neoplastic stromal cells but not to bone marrow derived stromal cells

Cited by 13 publications

References 50 publications

Bioactive glass selectively promotes cytotoxicity towards giant cell tumor of bone derived neoplastic stromal cells and induces MAPK signalling dependent autophagy

Bioactive glass selectively promotes cytotoxicity towards giant cell tumor of bone derived neoplastic stromal cells and induces MAPK signalling dependent autophagy

Nanostructured bioactive glasses: A bird's eye view on cancer therapy

Bioactive glasses incorporating less-common ions to improve biological and physical properties

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