Selective and early increase of IL-1 inhibitors, IL-6 and cortisol after elective surgery

Padova, Franco Di; Pozzi, Clara; Tondre, M J; Tritapepe, R

doi:10.1111/j.1365-2249.1991.tb05694.x

Cited by 102 publications

(27 citation statements)

References 27 publications

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“…OM and OA individuals and returned to baseline levels by day 4; finally, TNF-SR75 inereased following surgery in OM and OA but not in RA, and returned to baseline by day 4. Di Padova et ai failed to demonstrate an increase in TNF-a following surgery, but found increased levels of lL-1 inhibitors during the first post-operative 24 h [3]. To the best of our knowledge, this is the first time that a laek of increase in detectable TNF-a has been shown and correlated with an early increase in TNF-sR following surgery.…”

Section: Discussionmentioning

confidence: 65%

Tumour necrosis factor soluble receptors behave as acute phase reactants following surgery in patients with rheumatoid arthritis, chronic osteomyelitis and osteoarthritis

Chikanza

Roux‐Lombard

Dayer

et al. 1993

Clinical and Experimental Immunology

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SUMMARY Tumour necrosis factor‐alpha (TNF‐α) is involved in diverse biological processes including immune and inflammatory reactions and the response to surgical stress. Two soluble TNF receptor protein fragments. TNF‐sR55 (from the p55 kD TNF receptor) and TNF‐sR75 (from the p75 kD TNF receptor), are released by cells during inflammation and may modulate the effects of TNF‐α. We have studied the kinetics of secretion of TNF‐α, TNF‐sR55 and TNF‐sR75 in the sera of patients with rheumatoid arthritis (RA) and control subjects with osteoarthritis (OA) or chronic osteomyelitis (OM) before and after major surgery. Significantly higher pre‐operative levels of TNF‐sR55 and TNF‐sR75 were found in RA and OM as compared with OA (P<0.02). Following surgery, TNF‐sR55 increased within 24 h in RA, OM and OA (P<0.05), whereas TNF‐sR75 increased significantly only in OM and OA patients (P<0.05). By contrast, no TNF‐α was detectable before and after surgery in any of the subjects, but this may have been due to impaired detection (by ELISA) of TNF‐α when it is bound to TNF‐sR. These findings suggest that TNF‐sR55 and TNF‐sR75 may be further markers of the host's reaction to inflammatory insults. They may also play a role in modulating the immune and inflammatory reactions by inhibiting the systemic effects of TNF‐α.

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Section: Discussionmentioning

confidence: 65%

Tumour necrosis factor soluble receptors behave as acute phase reactants following surgery in patients with rheumatoid arthritis, chronic osteomyelitis and osteoarthritis

Chikanza

Roux‐Lombard

Dayer

et al. 1993

Clinical and Experimental Immunology

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“…Furthermore, it has been proposed that circulating levels of cytokines depend upon multiple factors including not just the type of stimulant but also the duration of exposure to the stimulant (Di Padova et al 1991). Hence, failure to detect significant changes in serum inflammatory markers may also be attributed to the short duration of the observed endotoxemia.…”

Section: Discussionmentioning

confidence: 99%

Endotoxemia and the host systemic response during experimental gingivitis

Wahaidi

Kowolik

Eckert

et al. 2011

Journal of Clinical Periodontology

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Aim To assess endotoxemia episodes and subsequent changes in serum inflammatory biomarkers using the experimental gingivitis model Materials and Methods Data from 50 healthy black and white adult males and females were compared for serum concentrations of endotoxin, and serum biomarkers [neutrophil oxidative activity, interleukin (IL)-1β, IL-6, IL-8, C-reactive protein, and fibrinogen] at baseline, at 3 weeks of experimental gingivitis, and after 2 weeks of recovery. Means were compared using repeated measures ANOVA. Results Endotoxemia was reported in 56% of the serum samples at three weeks of induced gingivitis. At two weeks of recovery, endotoxin levels decreased to levels similar to those reported at baseline. Neutrophil oxidative activity increased significantly following three weeks of gingivitis versus baseline (p<0.05). In the endotoxin-negative group this increase was associated with the black subjects whereas in the endotoxin-positive group change in neutrophil activity was driven by the female subpopulation. Serum cytokines, CRP, and fibrinogen levels did not change during the study. Conclusions Experimental gingivitis was associated with endotoxemia and hyperactivity of circulating neutrophils, but not with changes in systemic levels of cytokines and acute phase proteins. This may be attributed to the mild nature and the short duration of the induced gingivitis.

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“…Tissue‐level responses to the inhibition of IL‐1β in wound healing have been investigated using IL‐1ra. Inhibitors of pro‐inflammatory cytokines are naturally produced following injury 38 but are insufficient to prevent rampant inflammation that is thought to be partly responsible for imperfect healing. An example of this is in corneal injuries, where healed tissue is often characterized by dense vascularization and loss of optical transparency.…”

Section: Discussionmentioning

confidence: 99%

Biological activities of cytokine-neutralizing hyaluronic acid-antibody conjugates

Sun¹,

Bencherif

Gilbert

et al. 2010

Wound Repair and Regeneration

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Wound healing represents a highly regulated, orchestrated response of cells recruited to sites of injury. High molecular weight hyaluronic acid was conjugated with monoclonal antibodies to the cytokine interleukin-1beta to create a matrix-forming polymer capable of modifying healing. Using gel electrophoresis and fluorescence immunosorbent assays, we determined a degree of antibody functionalization per hyaluronic acid chain of 13.6+/-1.6%. The biological activity of the conjugate in vitro, measured using a nuclear factor-kappaB translocation assay in activated THP-1 monocytes, was comparable in inhibiting cytokine signaling to a similar level as the unconjugated antibody. Incisional wound studies in Sprague-Dawley rats indicates that viscous hyaluronic acid solutions were immunologically active, but covalent functionalization with antibodies against tumor necrosis factor-alpha and interleukin-1beta resulted in significant reductions in the inflammatory response. Covalent attachment of cytokine-neutralizing antibodies to matrix-forming polymers could lead to the development of materials capable of locally regulating wound healing and inflammatory responses in the setting of tissue regeneration.

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Selective and early increase of IL-1 inhibitors, IL-6 and cortisol after elective surgery

Cited by 102 publications

References 27 publications

Tumour necrosis factor soluble receptors behave as acute phase reactants following surgery in patients with rheumatoid arthritis, chronic osteomyelitis and osteoarthritis

Tumour necrosis factor soluble receptors behave as acute phase reactants following surgery in patients with rheumatoid arthritis, chronic osteomyelitis and osteoarthritis

Endotoxemia and the host systemic response during experimental gingivitis

Biological activities of cytokine-neutralizing hyaluronic acid-antibody conjugates

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