Selective apoptosis of lung cancer cells with talc

Lee, P.; Sun, Li-Yue; Lim, Che Kang; Aw, Swee Eng; Colt, Henri G.

doi:10.1183/09031936.00113109

Cited by 20 publications

(19 citation statements)

References 10 publications

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“…In a paradox, talc has been described as useful as a short‐term therapeutic agent for lung cancer. One study described how talc induced the selective apoptosis of lung cancer cells . This research suggests a rather suppressive role of talc in lung carcinogenesis.…”

Section: Discussionmentioning

confidence: 99%

A case of lung adenocarcinoma complicated by pulmonary talcosis occurring in a patient employed in the confectionery industry

Kobayashi

Watanabe

Oka

et al. 2019

Pathology International

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A 73‐year‐old Japanese man, who worked at a confectionery company for more than 20 years, was diagnosed with a 28 mm nodular lesion in the superior lobe of the right lung by whole‐body computed tomography examination. A biopsy revealed the presence of adenocarcinoma. With a diagnosis of a primary lung cancer, a right upper lobectomy was performed. A nodular lesion, 25 × 23 mm in size, was observed in the upper right lobe lung field, and was diagnosed histopathologically as a papillary adenocarcinoma. In addition, fibrous scars in the central part of the tumor showed numerous Langhans and/or foreign body giant cells, and histiocytic cells that had phagocytized numerous small transparent crystals, together with coal powder deposition. The extracted crystals were observed with a scanning electron microscope, and although plate‐like structures were observed, ferruginous bodies suggestive of asbestos were not found. The crystals were demonstrated to be talc by powder X‐ray diffraction. Herein, we investigated a case of lung adenocarcinoma in a patient with talcosis, with discussions based on a literature search. This collision of talcosis and lung adenocarcinoma adds to an increasing body of knowledge on an apparent association between talc and cancer cases.

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Section: Discussionmentioning

confidence: 99%

A case of lung adenocarcinoma complicated by pulmonary talcosis occurring in a patient employed in the confectionery industry

Kobayashi

Watanabe

Oka

et al. 2019

Pathology International

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“…Nasreen et al have previously shown that talc was capable of inducing apoptosis in malignant pleural mesothelioma cells but not in benign mesothelial cells. In addition, Lee and co‐workers treated lung adenocarcinoma cells and benign cells obtained from patients with talc, doxycycline and bleomycin. Apoptosis as determined by flow cytometry was observed in lung adenocarcinoma cells exposed to talc, doxycycline and bleomycin, with talc producing the highest apoptotic rates.…”

Section: Discussionmentioning

confidence: 99%

Survivin is a negative prognostic factor in malignant pleural effusion

Arellano-Orden

Romero-Romero

Sánchez-López

et al. 2018

Eur J Clin Investigation

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“…Talc-treated pleural mesothelium counteracts these effects by releasing endostatin, an anti-angiogenic factor which may be responsible for tumor containment within the pleural space and accounts for the improved clinical outcome of patients with malignant pleural effusions successfully pleurodesis with talc [24]. Lee et al [25] demonstrated that talc causes apoptosis of lung cancer cells in a dose- and time-dependent manner. However, this process is selective and spares the normal mesothelium.…”

Section: Discussionmentioning

confidence: 99%

Role of Talc Modulation on Cytokine Activation in Cancer Patients Undergoing Pleurodesis

Schwarz

Star

2012

Pulmonary Medicine

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We investigate the mechanism of talc pleurodesis (TP) in 20 patients with recurrent malignant pleural effusion and 10 patients with nonmalignant pleural effusions. We measured IL-8 levels before and 6 h after TP and find a significant threefold increase (2.26 ng/mL ± 0.7 to 6.5 ng/mL 0.1), which explains the recruitment of inflammatory cells in these patients. We hypothesize that TP is enable by stimulating the mesothelial cells (MS) to secrete FGF. A significant tenfold increase in FGF-b (0.05 ng/mL ± 0.02 to 0.44 ng/mL 0.6) was seen 24 h after talc instillation (P < 0.04). In order to examine whether FGF-b is secreted by MS cells, MS recovered from CHF patients with recurrent pleural effusions were cultured for 48 h in the presence or absence of increasing concentrations of talc (from 100 ng/mL to 1 mg/mL). They produced significant levels of FGF-b in a dose dependent manner (P < 0.005). We hypothesized that a successful pleurodesis involves an early enhanced recruitment of inflammatory cells through a rise of IL-8 followed by enrollment of fibroblasts from the submesothelial space through increased mesothelial FGF-b production.

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Selective apoptosis of lung cancer cells with talc

Cited by 20 publications

References 10 publications

A case of lung adenocarcinoma complicated by pulmonary talcosis occurring in a patient employed in the confectionery industry

A case of lung adenocarcinoma complicated by pulmonary talcosis occurring in a patient employed in the confectionery industry

Survivin is a negative prognostic factor in malignant pleural effusion

Role of Talc Modulation on Cytokine Activation in Cancer Patients Undergoing Pleurodesis

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