Selective aspects of human pathology in high-tone hearing loss of the aging inner ear

Scholtz, Arne W.; Kammen‐Jolly, Keren; Felder, Edward; Hussl, B; Rask‐Andersen, Helge; Schrott‐Fischer, Anneliese

doi:10.1016/s0378-5955(01)00279-9

Cited by 26 publications

(14 citation statements)

References 33 publications

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“…This pathologic alteration has been described by Scholtz et al in the aging inner ear in association with high-tone hearing loss (Scholtz et al, 2001). A similar observation has been made in the inner ears of chincillas exposed with the ototoxic drug kanamycin.…”

Section: Discussionsupporting

confidence: 80%

Does perinatal asphyxia induce apoptosis in the inner ear?

et al. 2009

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Section: Discussionsupporting

confidence: 80%

Does perinatal asphyxia induce apoptosis in the inner ear?

et al. 2009

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“…Two more categories have subsequently been added: mixed and indeterminate. The latter has been reported to account for 25% of cases [20] and in most cases, a mixture of pathological changes have been noted [21]. Although there is a general consensus that the cochlea is the site of ARHL, otopathologic changes to the inner ear as a direct function of age remain controversial.…”

Section: Pathophysiology Associated With Presbycusismentioning

confidence: 99%

Ageing and hearing loss

Yan

2007

The Journal of Pathology

278

178

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Although many adults retain good hearing as they age, hearing loss associated with ageing is common among elderly persons. There are a number of pathophysiolological processes underlying age-related changes to functional components in the inner ear. Genetic factors determine the ageing process but are under the influence of intrinsic and environmental factors. It is difficult to distinguish changes of normal ageing from those of other contributing factors. The effects of age-related deafness can have significant physical, functional and mental health consequences. Although a deficit in hearing can be corrected to some degree by a hearing aid or other appropriate amplification devices, hearing-related rehabilitative needs are much more than simply amplifying external sound. Only by better understanding the process of ageing and its effect on the auditory function can we better accommodate elderly people in our day-to-day interactions. We review here the structure and function of the inner ear, pathophysiology associated with age-related hearing loss (ARHL), heritability, allelism and modifier genes of ARHL, and evaluate the genetic analyses for identification of genetic factors that are involved.

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“…Interpretation of human temporal bone studies has been hampered by poor specimen preservation, incomplete life histories, and genetic variance. To date, disagreement remains as to how many distinct forms of ARHL there are and what risk factors may predispose an individual to a particular form (Suga and Lindsay, 1976; Jennings and Jones, 2001; Scholtz et al, 2001). There are also a host of issues regarding the specific attributes of different forms of ARHL.…”

mentioning

confidence: 99%

Crystallinity morphology and dynamic mechanical characteristics of PBT polymer and glass fiber‐reinforced composites

Park

Lee

Kim

et al. 2002

J of Applied Polymer Sci

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ABSTRACT:The crystalline morphologies of PBT (poly butylene terephthalate) and its glass fiber reinforced composite systems were investigated in a thin-film form by polarized optical microscopy and wide-angle X-ray diffraction. Three different types of PBT morphology were identified in the Maltese cross pattern: 45°cross pattern (usual type) by solvent crystallization, 90°cross pattern (unusual type) by melt crystallization at low crystallization temperature, and mixed type by melt crystallization at crystallization temperatures higher than 160°C. The glass fibers increased the number density of spherulites and decreased the size of crystallites acting as crystallization nucleation sites without exhibiting trans-crystallinity at the vicinity of the glass fiber surfaces. Finally, the storage modulus was analyzed by using a dual-phase continuity model describing the modulus by the power-law sum of the amorphous-and crystalline-phase moduli. The crystalline-phase modulus was extracted out from the PBT polymer and composite systems containing different amount of crystallinity. © 2002 Wiley Periodicals, Inc. J Appl Polym Sci 86: 478 -488, 2002

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Selective aspects of human pathology in high-tone hearing loss of the aging inner ear

Cited by 26 publications

References 33 publications

Does perinatal asphyxia induce apoptosis in the inner ear?

Does perinatal asphyxia induce apoptosis in the inner ear?

Ageing and hearing loss

Crystallinity morphology and dynamic mechanical characteristics of PBT polymer and glass fiber‐reinforced composites

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