Selective autophagy in cancer: mechanisms, therapeutic implications, and future perspectives

Liu, Jiaxi; Wu, Yongya; Meng, Sha; Xu, Ping; Li, Shutong; Li, Yong; Hu, Xiuying; Ouyang, Liang; Wang, Guan

doi:10.1186/s12943-024-01934-y

Cited by 23 publications

(1 citation statement)

References 228 publications

(255 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Critical areas that require further investigation include cargo recognition and binding mechanisms encapsulated within the “cargo‐ligand‐receptor” paradigm. 93 , 94 Elucidating these interactions demands the refinement and application of sophisticated imaging methods that can accurately depict the complex interplay between autophagic components and other cellular structures. Furthermore, the study of microautophagy, hindered by the absence of standardized methods and appropriate models, 95 underscores the necessity for innovative experimental designs, particularly utilizing gene knockout mice to probe the regulatory pathways governing autophagy's various forms.…”

Section: Conclusion and Perspectivementioning

confidence: 99%

Unraveling the ultrastructure and dynamics of autophagic vesicles: Insights from advanced imaging techniques

Jiang,

Ma,

Chen

2024

FASEB BioAdvances

View full text Add to dashboard Cite

Autophagy, an intracellular self‐degradation process, is governed by a complex interplay of signaling pathways and interactions between proteins and organelles. Its fundamental purpose is to efficiently clear and recycle cellular components that are damaged or redundant. Central to this process are autophagic vesicles, specialized structures that encapsulate targeted cellular elements, playing a pivotal role in autophagy. Despite growing interest in the molecular components of autophagic machinery and their regulatory mechanisms, capturing the detailed ultrastructural dynamics of autophagosome formation continues to present significant challenges. However, recent advancements in microscopy, particularly in electron microscopy, have begun to illuminate the dynamic regulatory processes underpinning autophagy. This review endeavors to provide an exhaustive overview of contemporary research on the ultrastructure of autophagic processes. By synthesizing observations from diverse technological methodologies, this review seeks to deepen our understanding of the genesis of autophagic vesicles, their membrane origins, and the dynamic alterations that transpire during the autophagy process. The aim is to bridge gaps in current knowledge and foster a more comprehensive comprehension of this crucial cellular mechanism.

show abstract

Section: Conclusion and Perspectivementioning

confidence: 99%

Unraveling the ultrastructure and dynamics of autophagic vesicles: Insights from advanced imaging techniques

Jiang,

Ma,

Chen

2024

FASEB BioAdvances

View full text Add to dashboard Cite

show abstract

Gastric Cancer Actively Remodels Mechanical Microenvironment to Promote Chemotherapy Resistance via MSCs‐Mediated Mitochondrial Transfer

He,

Zhong,

Wang

et al. 2024

Advanced Science

View full text Add to dashboard Cite

Chemotherapy resistance is the main reason of treatment failure in gastric cancer (GC). However, the mechanism of oxaliplatin (OXA) resistance remains unclear. Here, we demonstrate that extracellular mechanical signaling plays crucial roles in OXA resistance within GC. We selected OXA‐resistant GC patients and analyzed tumor tissues by single‐cell sequencing, and found that the mitochondrial content of GC cells increased in a biosynthesis‐independent manner. Moreover, we found that the increased mitochondria of GC cells were mainly derived from mesenchymal stromal cells (MSCs), which could repair the mitochondrial function and reduce the levels of mitophagy in GC cells, thus leading to OXA resistance. Furthermore, we investigated the underlying mechanism and found that mitochondrial transfer was mediated by mechanical signals of the extracellular matrix (ECM). After OXA administration, GC cells actively secreted ECM in the tumor microenvironment (TEM), increasing matrix stiffness of the tumor tissues, which promoted mitochondria to transfer from MSCs to GC cells via microvesicles (MVs). Meanwhile, inhibiting the mechanical‐related RhoA/ROCK1 pathway could alleviate OXA resistance in GC cells. In summary, these results indicate that matrix stiffness could be used as an indicator to identify chemotherapy resistance, and targeting mechanical‐related pathway could effectively alleviate OXA resistance and improve therapeutic efficacy.

show abstract

Advances in Polymeric Nanomaterial‐mediated Autophagy for Cancer Therapy

Zhao,

Hou,

Zhao

et al. 2024

ChemBioChem

View full text Add to dashboard Cite

Autophagy is an important biological mechanism for eukaryotic cells to regulate growth, death, and energy metabolism, and plays an important role in removing damaged organelles, misfolded or aggregated proteins, and clearing pathogens. It has been found that autophagy is closely related to cell survival and death, and is of great significance in cancerigenesis and development, playing a bidirectional role in cancer inhibition and cancer promotion. Therefore, treating cancers by regulating autophagy has attracted much attention. A large amount of research evidence indicates that polymeric nanomaterials are able to regulate cellular autophagy, and their good biocompatibility, degradability, and functionalizable modification open up a broad application prospect for improving the therapeutic effect of cancers. This review provides an overview of the research progress of polymeric nanomaterials for modulating autophagy in the treatment of cancers.

show abstract

Selective autophagy in cancer: mechanisms, therapeutic implications, and future perspectives

Cited by 23 publications

References 228 publications

Unraveling the ultrastructure and dynamics of autophagic vesicles: Insights from advanced imaging techniques

Unraveling the ultrastructure and dynamics of autophagic vesicles: Insights from advanced imaging techniques

Gastric Cancer Actively Remodels Mechanical Microenvironment to Promote Chemotherapy Resistance via MSCs‐Mediated Mitochondrial Transfer

Advances in Polymeric Nanomaterial‐mediated Autophagy for Cancer Therapy

Contact Info

Product

Resources

About