Selective bioaccumulation of neonicotinoids and sub-lethal effects in the earthworm Eisenia andrei exposed to environmental concentrations in an artificial soil

Chevillot, Fanny; Convert, Yannice; Desrosiers, Mélanie; Cadoret, Nicole; Veilleux, Éloïse; Cabana, Hubert; Bellenger, Jean‐Philippe

doi:10.1016/j.chemosphere.2017.08.046

Cited by 45 publications

(33 citation statements)

References 44 publications

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“…Ultimately, the determination of the lowest tissue concentrations of neonicotinoids that are capable of inducing altered physiology and behavior in laboratory animals, will allow comparisons with the concentrations in food, drinking water, and human tissues. Documented evidence for neonicotinoid bioaccumulation in non-insect invertebrates 54 and in humans 43 , and the identification of active metabolites of IMI and other neonicotinoids 55 – 60 adds further incentive for conducting such studies.…”

Section: Discussionmentioning

confidence: 99%

Mammalian Susceptibility to a Neonicotinoid Insecticide after Fetal and Early Postnatal Exposure

Burke

Niibori

Terayama

et al. 2018

Sci Rep

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Neonicotinoids have become the most widely used class of insecticides world-wide. Although numerous studies have documented neonicotinoid toxicity in bees and other insects, the effects of exposure during early development in mammals remain largely unexplored. We assessed the effects of the neonicotinoid imidacloprid (IMI) in adult male and female mice after in utero and early postnatal exposure. Pregnant mice were infused with IMI (0.5 mg/kg/day) from gestational day 4 to the end of nursing at postnatal day 21. The young adult offspring were studied in a series of biochemical and behavioral tests. To assess reproducibility, the behavioral analyses were conducted in three separate studies using multiple exposed litters. Exposure to IMI reduced fecundity, and in adult offspring, decreased body weight in male but not female pups. Offspring from IMI-treated mothers displayed lower triglycerides, elevated motor activity, enhanced social dominance, reduced depressive-like behavior, and a diminution in social aggression compared to vehicle treated controls. Low levels of IMI were detected in the brains and livers of the treated mothers, while trace levels were detected in some offspring. Our results demonstrate that transient exposure to a neonicotinoid over the early developmental period induces long-lasting changes in behavior and brain function in mice.

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Section: Discussionmentioning

confidence: 99%

Mammalian Susceptibility to a Neonicotinoid Insecticide after Fetal and Early Postnatal Exposure

Burke

Niibori

Terayama

et al. 2018

Sci Rep

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“…In addition, the USEPA (2005) noted a major risk concern for honey bees potentially exposed to clothianidin because of its toxicity to bees and recommended caution during applications. However, concern for the environmental impacts of neonicotinoids extend beyond the potential effects to bees (Chevillot et al, 2017;Han, Tian & Shen, 2018;Hallmann et al, 2014;Morrissey et al, 2015;Zhang et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Uptake and toxicity of clothianidin to monarch butterflies from milkweed consumption

Bargar

Hladik

Daniels

2020

PeerJ

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Recent concern for the adverse effects from neonicotinoid insecticides has centered on risk for insect pollinators in general and bees specifically. However, natural resource managers are also concerned about the risk of neonicotinoids to conservation efforts for the monarch butterfly (Danaus plexippus) and need additional data to help estimate risk for wild monarch butterflies exposed to those insecticides. In the present study, monarch butterfly larvae were exposed in the laboratory to clothianidin via contaminated milkweed plants from hatch until pupation, and the effects upon larval survival, larval growth, pupation success, and adult size were measured. Soils dosed with a granular insecticide product led to mean clothianidin concentrations of 10.8–2,193 ng/g in milkweed leaves and 5.8–58.0 ng/g in larvae. Treatment of soils also led to clothianidin concentrations of 2.6–5.1 ng/g in adult butterflies indicating potential for transfer of systemic insecticides from the soil through plants and larvae to adult butterflies. Estimated LC50s for total mortality (combined mortality of larvae and pupae) and EC50 for larval growth were variable but higher than the majority of concentrations reported in the literature for clothianidin contamination of leaves.

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“…Imidacloprid was also shown to be toxic to earthworm Eisenia fetida (Savigny) (108,109) and Hyalella azteca (Saussure) (110). Eisenia andrei (Bouché) showed bioaccumulation of various pesticides, which correlated with DNA damage (111). Van Hoesel et al (112) also found reduced surface activity of earthworms in pots with wheat treated by seed dressing formulation based on imidacloprid and a fungicide prothioconazole.…”

Section: Non-target Toxicity Of Neonicotinoids In Other Insects and Imentioning

confidence: 99%

Non-target toxicity of novel insecticides

Mužinić

Želježić

2018

Archives of Industrial Hygiene and Toxicology

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Humans have used insecticides since ancient times. The spectrum and potency of available insecticidal substances has greatly expanded since the industrial revolution, resulting in widespread use and unforeseen levels of synthetic chemicals in the environment. Concerns about the toxic effects of these new chemicals on non-target species became public soon after their appearance, which eventually led to the restrictions of use. At the same time, new, more environmentally-friendly insecticides have been developed, based on naturally occurring chemicals, such as pyrethroids (derivatives of pyrethrin), neonicotinoids (derivatives of nicotine), and insecticides based on the neem tree vegetable oil (Azadirachta indica), predominantly azadirachtin. Although these new substances are more selective toward pest insects, they can still target other organisms. Neonicotinoids, for example, have been implicated in the decline of the bee population worldwide. This review summarises recent literature published on non-target toxicity of neonicotinoids, pyrethroids, and neem-based insecticidal substances, with a special emphasis on neonicotinoid toxicity in honeybees. We also touch upon the effects of pesticide combinations and documented human exposure to these substances.

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Selective bioaccumulation of neonicotinoids and sub-lethal effects in the earthworm Eisenia andrei exposed to environmental concentrations in an artificial soil

Cited by 45 publications

References 44 publications

Mammalian Susceptibility to a Neonicotinoid Insecticide after Fetal and Early Postnatal Exposure

Mammalian Susceptibility to a Neonicotinoid Insecticide after Fetal and Early Postnatal Exposure

Uptake and toxicity of clothianidin to monarch butterflies from milkweed consumption

Non-target toxicity of novel insecticides

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