Selective Cytotoxicity of Complexes with N,N,N-Donor Dipodal Ligand in Tumor Cells

Abstract

The present article demonstrates selective cytotoxicity against cancer cells of the complexes [Co(LD)2]I2∙CH3OH (1), [CoLD(NCS)2] (2) and [VOLD(NCS)2]∙C6H5CH3 (3) containing the dipodal tridentate ligand LD = N,N-bis(3,5-dimethylpyrazol-1-ylmethyl)amine), formed in situ. All tested complexes expressed greater anticancer activities and were less toxic towards noncancerous cells than cisplatin. Cobalt complexes (1 and 2) combined high cytotoxicity with selectivity towards cancer cells and caused massive tumour cell death. The vanadium complex (3) induced apoptosis specifically in cancer cells and targeted proteins, controlling their invasive and metastatic properties. The presented experimental data and computational prediction of drug ability of coordination compounds may be helpful for designing novel and less toxic metal-based anticancer species with high specificities towards tumour cells.

Migration inhibition and selective cytotoxicity of cobalt hydroxide nanosheets on different cancer cell lines

“…In conclusion, the above results of morphology observation and cell viability assays demonstrated that β-Co(OH) 2 NSs have certain selectivity to normal cells and cancer cells, and have significantly stronger cytotoxicity to cancer cells. The selective cytotoxicity of β-Co(OH) 2 NSs to cancer cells is similar to that of cobalt( ii ) complexes 35,36 or cobalt-based nanomaterials 37,38 reported previously in the literature. This suggests that this tumor cell-selective toxicity may be attributed to the presence of cobalt.…”

Newly-Obtained Two Organic-Inorganic Hybrid Compounds Based on Potassium Peroxidomolybdate and Dicarboxypyridinic Acid: Structure Determination, Catalytic Properties, and Cytotoxic Effects of Eight Peroxidomolybdates in Colon and Hepatic Cancer Cells

“…MTT formazan generated during incubation was dissolved and the absorbance was recorded at 550 nm (the reference wavelength was 690 nm) using a microplate reader Infinite M200 Pro, Tecan, Austria. IC 50 values were calculated from the concentration—response curves (IC 50 was the concentration [μM/L] of a tested compound required to decrease the cell proliferation to 50% of the control) [ 32 ]. All data were expressed as arithmetic mean values with standard deviation (M; ±SD).…”

Synthesis, characterization, biological evaluation, DFT and molecular docking studies of (Z)-2-((2-bromo-4-chlorophenyl)imino)methyl)-4-chlorophenol and its Co(ii), Ni(ii), Cu(ii), and Zn(ii) complexes

“…Toxicity effect of the complexes was evaluated on normal human cell lines comprises of (WISH-ATCC-CCL-25, human epithelial amnion (liver cell lines), and MRC-5-ATCC-CCL-171, human lung fibroblast cell lines), using MTT method. 36,37 Samples concentrations of 50 and 100 μM were used against these cell lines. 200 μL representing ((1 × 10 4 cells per well) was seeded into 96-well plates and incubated at 37 °C for 24 hours in 5% CO 2 atmosphere.…”