Selective Determination of Atropine Using poly Dopamine-Coated Molecularly Imprinted Mn-Doped ZnS Quantum Dots

Abstract

In this study, a selective method for the determination of atropine in pharmaceutical formulations was proposed. L-cysteine capped Mn-doped ZnS quantum dots (QDs) were prepared in an in-situ method using sodium thiosulfate precursor and characterized by spectrofluorometer, Fourier transform infrared spectroscopy (FT-IR), transmission electron microscope (TEM) and X-ray diffractometer (XRD). Dopamine hydrochloride was used as a precursor for preparation of poly dopamine-coated molecularly imprinted Mn-doped ZnS quantum dots. Finally, these prepared molecularly imprinted Mn-doped ZnS quantum dots were used for determination of atropine in pharmaceutical formulations. The obtained linear range for determination of atropine was in the range of 2 × 10(-8) - 7 × 10(-6) M, with a correlation coefficient (R(2)) of 0.9889; and the detection limit (S/N = 3) was 3.2 nM.

<p>Toxicity and serum metabolomics investigation of Mn-doped ZnS quantum dots in mice</p>

“…ZnS quantum dots (QDs) are IIB–VIA semiconductors and are considered to be good hosts when doped with Mn (3D transition metal ions) 1. Depending on their special luminescence property, Mn-doped ZnS QDs have been used for the detection of various substances by different surface modifications, including metal ions [copper(II), Fe(II), manganese(VII), and Pb(II)],2–5 environmental hazards (halobenzoquinones, patulin, florfenicol, and nicosulfuron),6–9 cocaine and its metabolites,10–12 drugs (atropine),13 biological molecules (thrombin,14 serotonin/5-hydroxytryptamine,15 dopamine,16 xanthine oxidase,17 prostate-specific antigen,18 glycoproteins19 and DNA20), and cancer cells 21. The widespread use of Mn-doped ZnS QDs has raised many toxicological concerns.…”

An organic transistor for the selective detection of tropane alkaloids utilizing a molecularly imprinted polymer

“…36–38 However, previous works on the use of MIPs for the detection of atropine did not report on the selective discrimination of ( S )-hyoscyamine. 39–42 Besides, previous reports have confirmed that MIPs can be formed as thin layers or membranes on substrates including electrodes, 43–46 interfacing MIPs with the extended-gate electrode should be possible. Indeed, the detectability of extended-gate-type inorganic FETs functionalized with MIPs for various chemical species has already been reported.…”

New Advanced Materials and Sorbent-Based Microextraction Techniques as Strategies in Sample Preparation to Improve the Determination of Natural Toxins in Food Samples

“…Indeed, only two works have reported the microextraction of opiates by MEPS and µ -MSPE, but from biological samples (blood and human hair, respectively) instead of food [85,86]. Regarding the development of new materials for the extraction of these compounds, apart from the MNPs functionalized with silane groups which were prepared as sorbent for the microextraction of morphine from human hair [86], different MIP materials have been synthesized for the selective extraction of tropane alkaloids [87][88][89][90]. In these works, MIPs for the extraction of atropine and scopolamine have been applied as sorbents in pharmaceutical formulations [87,88] and biological samples (urine and plasma samples) [89], except the work published by Zeng et al, which employs a MIP for the extraction of four tropane alkaloids (including scopolamine, atropine, anisodine and anisodamine) from fruit samples [90], which was the only one applied for food sample preparation.…”