Selective Determination of Nicorandil with a Single Planar Solid‐state Potentiometric Ion Selective Electrode

Abstract

Novel screen-printed electrodes (SPEs) were constructed for the quantitation of nicorandil (NIC) in its pharmaceutical formulations. Different ion-exchangers and plasticizers were investigated, but the optimal potentiometric response was obtained using nicorandilphosphotungstate (NIC-PTA) ion associate and tricresyl phosphate as a plasticizer. A Nernstian response of 58.80 � 1 mV/decade was obtained over a concentration range of (1 × 10 À 6 -1 × 10 À 2 ) M with 1 × 10 À 5 M as a detection limit. Sensor morphology was characterized using scanning electron microscopy (SEM). The method was validated for the assay of NIC with high selectivity, accuracy (average recovery = 100.54 %), and precision (% RSD � 2).