Selective Diagnosis of Diabetes Using Pt-Functionalized WO₃ Hemitube Networks As a Sensing Layer of Acetone in Exhaled Breath

Abstract

Thin-walled WO(3) hemitubes and catalytic Pt-functionalized WO(3) hemitubes were synthesized via a polymeric fiber-templating route and used as exhaled breath sensing layers for potential diagnosis of halitosis and diabetes through the detection of H(2)S and CH(3)COCH(3), respectively. Pt-functionalized WO(3) hemitubes with wall thickness of 60 nm exhibited superior acetone sensitivity (R(air)/R(gas) = 4.11 at 2 ppm) with negligible H(2)S response, and pristine WO(3) hemitubes showed a 4.90-fold sensitivity toward H(2)S with minimal acetone-sensing characteristics. The detection limit (R(air)/R(gas)) of the fabricated sensors with Pt-functionalized WO(3) hemitubes was 1.31 for acetone of 120 ppb, and pristine WO(3) hemitubes showed a gas response of 1.23 at 120 ppb of H(2)S. Long-term stability tests revealed that the remarkable selectivity has been maintained after aging for 7 months in air. The superior cross-sensitivity and response to H(2)S and acetone gas offer a potential platform for application in diabetes and halitosis diagnosis.

Catalyst-decorated hollow WO 3 nanotubes using layer-by-layer self-assembly on polymeric nanofiber templates and their application in exhaled breath sensor

“…In particular, 1-D hollow tubular structures are attractive for gas sensors due to their increased surface area (i.e., inner and outer surface) as well as high porosity by facilitating effective gas transport through the sensing layers, thereby improving gas sensitivity. For example, 1-D TiO 2 nanotubes (NTs) [16], WO 3 hemitubes [4,17], ZnO NTs [18], and InGaZnO 4 NTs [19] were proposed for gas sensing layers synthesized by sacrificial templating route. In addition, catalyst-loaded 1-D tubular structures such as Pt-WO 3 hemitubes [17], Pt-NiO NTs [20], Ag-V 2 O 5 NTs [21], and Pd-TiO 2 NTs [22] were demonstrated via surface functionalization of oxide sensing layers by separately synthesizing catalytic nanoparticles for further improvement of sensitivity and selectivity.…”

Fabrication of a low-concentration H2S gas sensor using CuO nanorods decorated with Fe2O3 nanoparticles

“…More recently, gas sensing devices have been used to make medical diagnoses [5,6]. For example, exhaled human breath can include several gases whose presence can be used as criteria for disease diagnosis [7][8][9][10]. Halitosis, or bad breath, affects more that 20% of the population and can lead to social anxiety.…”

Enhanced sensitive and selective xylene sensors using W-doped NiO nanotubes

“…Consequently, a simple method is needed to detect xylene. In recent years, gas sensor based on metal oxide semiconductor nanomaterials, such as SnO 2 [7][8][9][10], WO 3 [11][12][13][14], In 2 O 3 [15][16][17][18] and NiO [19][20][21][22], has attracted much attention for harmful, environmental, explosive and toxic gas detection, and they are possible candidates as xylene sensors due to their advantages of high response to target gases, simplicity in preparation and costeffective. However, the design of high performance xylene sensors based on semiconductor is still in the early stages of investigation.…”